HOME >> MEDICINE >> NEWS
Blocking stress protein decreases Alzheimer's peptide in mice

St. Louis, June 4, 2007 Scientists revealed in November 2006 that stress increases production in mice of a brain peptide critical to Alzheimer's disease. Now the same group has shown that blocking a different brain peptide slows the stress-induced increase, opening a new door to treatment. Researchers from Washington University School of Medicine in St. Louis report the results online this week in the Proceedings of the National Academy of Sciences.

Studies of humans and animals have suggested that stress may increase risk of Alzheimer's disease, but the new research is among the first studies to elaborate the basic biomolecular mechanisms that may underlie this increased risk.

The results build on earlier findings from coauthors John G. Csernansky, M.D., the Gregory B. Couch Professor of Psychiatry and professor of neurobiology, and Hongxin Dong, Ph.D., instructor in psychiatry. Using mice genetically modified to model human Alzheimer's disease, Csernansky and Dong showed that raising them under isolated conditions in smaller cages accelerated the deposition of brain plaques and declines in cognitive ability.

Brain plaques are believed to be a primary cause of the memory loss and other mental damage inflicted by Alzheimer's disease. They are mostly comprised of a peptide known as amyloid beta, so researchers immediately suspected that stress was increasing amyloid beta levels. But because there are other factors that can accelerate plaque build-up, they needed to test the link.

For that new test, scientists used a technique known as microdialysis to monitor amyloid beta levels in the brains of mice exposed to the same stressors: isolation and smaller cages.

"Stress remarkably elevated soluble amyloid beta levels in the spaces between brain cells," says senior author David Holtzman, M.D., the Andrew B. and Gretchen P. Jones Professor and head of the Department of Neurology. "But we didn't know based on those initial experiments if it was
'"/>

Contact: Jim Dryden
jdryden@wustl.edu
314-286-0110
Washington University School of Medicine
4-Jun-2007


Page: 1 2

Related medicine news :

1. Blocking immune cell action increases Alzheimers-associated protein deposits
2. Blocking an inter-generational cycle of obesity
3. Blocking key protein reduces inflammatory markers in metabolic syndrome
4. Blocking previously unrecognized links between inflammatory systems could make COX-2 inhibitors safe
5. Blocking the nerve receptor EP1 in mouse models reduces brain damage caused by stroke
6. Blocking the Odc gene is effective in preventing cancers
7. Reductive stress linked to heart disease
8. New study shows Rescue Remedy is an effective all-natural stress, anxiety reliever
9. Reduced greenhouse gas emissions required to avoid dangerous increases in heat stress
10. Improving communication with families of dying patients reduces stress, anxiety and depression
11. Post-traumatic stress disorder 10 times higher in New Orleans than in the general public

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/19/2020)... LOUIS (PRWEB) , ... February 19, 2020 , ... ... the availability of and application deadline for its new Lifestyle Medicine Residency Curriculum ... designed for integrated implementation into medical residency programs. Driven by resident involvement, ...
(Date:2/19/2020)... ... 2020 , ... In 2017, the EU’s revamped Medical Device ... currently govern medical device manufacturers under the Medical Devices Directive (MDD); the timeline ... changes from the previous MDD include:, , Elimination of ...
(Date:2/19/2020)... ... February 19, 2020 , ... SEAL SHIELD, LLC - Almost a hundred ... infections (HAIs.) According to The Centers for Disease Control (CDC), 80% of infections are ... screens that are now acting as an extension of people’s hands, but not getting ...
(Date:2/16/2020)... ... February 16, 2020 , ... Canadian digital healthcare portal Ask The ... who are concerned about the Coronavirus. , "It is our duty and it is ... this deadly virus" said Prakash Chand, CEO of Ask The Doctor. , Doctors and ...
(Date:2/15/2020)... ... ... It all started back in 2010, when Jennifer Martinez (Founder) was delighted that ... on to something special. The Heartsters have now become a circle of friends ... condition or illness, a disability or just having a bad day. , “It ...
Breaking Medicine News(10 mins):
(Date:2/20/2020)... ... February 20, 2020 , ... PAINWeekEnd on March ... Arizona, will be a timely and relevant 2-day program providing busy clinicians and ... of chronic pain. , In 2020, paper prescriptions for certain painkillers have been ...
(Date:2/19/2020)... ... February 19, 2020 , ... Today, ... skilled nursing facility rehospitalization rate are the lowest in the company’s history. ... 29 percent drop year over year. GHC’s skilled nursing facility (SNF) rehospitalization rate ...
(Date:2/19/2020)... ... February 19, 2020 , ... ... platform for research data management, has released a new SnapGene ... management features. With a ‘Quick View’ of supported DNA files, the molecular ...
Breaking Medicine Technology:
Cached News: