HOME >> MEDICINE >> NEWS
Blocking the Odc gene is effective in preventing cancers

Drugs that block the enzyme Odc prevent the onset of cancers that would otherwise be triggered by a family of cancer-causing genes called Myc, according to investigators at St. Jude Children's Research Hospital. The researchers showed that disabling Odc disrupts the ability of Myc genes to speed up cell division. Myc controls the expression of many genes; but the investigators showed that disrupting just this one target delays the onset of cancer in a laboratory model that mimics human Burkitt lymphoma (BL). BL is a cancer of B lymphocytes, immune system cells that produce antibodies.

The researchers showed that either treatment with Odc-suppressing drug DFMO or the loss of one of the two copies of the Odc gene in a B lymphocyte impairs Myc's ability to stimulate uncontrolled cell division. The team made these findings in E-Myc laboratory models, which overexpress Myc in B cells and are widely used in laboratory studies of cancer.

The discovery of the link between Odc and Myc in tumor development is significant because Myc genes are activated in up to 70 percent of human cancers. Therefore, a drug that disrupts their activity by disabling Odc might prevent or slow the development of a wide variety of cancers, including breast, colon, lung and prostate cancers. However, while DFMO treatment was effective in preventing lymphoma development in the E-Myc model, it only worked when cells had an intact tumor-suppressing mechanism called the Arf-p53 pathway. This suggests that cancers carrying mutations that disable Arf-p53 would not respond to DFMO, the researchers said.

"Each time a cell divides it must make a copy of the genome to transmit it to the new daughter cells, a process that is vulnerable to mistakes that cause mutations," said John Cleveland, Ph.D., a member of the Department of Biochemistry at St. Jude. "Curtailing cell division reduces the chance that cancer-causing mutations will occur, which is especially important in cells that already
'"/>

Contact: Kelly Perry
kelly.perry@stjude.org
901-495-3306
St. Jude Children's Research Hospital
16-May-2005


Page: 1 2 3

Related medicine news :

1. Blocking stress protein decreases Alzheimers peptide in mice
2. Blocking immune cell action increases Alzheimers-associated protein deposits
3. Blocking an inter-generational cycle of obesity
4. Blocking key protein reduces inflammatory markers in metabolic syndrome
5. Blocking previously unrecognized links between inflammatory systems could make COX-2 inhibitors safe
6. Blocking the nerve receptor EP1 in mouse models reduces brain damage caused by stroke
7. New treatment effective in counteracting cocaine-induced symptoms
8. Osteoporosis screening and treatment may be cost-effective for selected older men
9. Study shows radiofrequency ablation highly effective in treating kidney tumors
10. New study examines effectiveness of tailored health messages
11. Scaling up HIV prevention programs is cost effective

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/4/2020)... BRENTWOOD, Tenn. (PRWEB) , ... June 04, 2020 ... ... behavioral health and substance abuse treatment services has announced the addition of the ... will be integrated into the larger treatment curriculum at each facility to provide ...
(Date:6/2/2020)... LANSDALE, Pa. (PRWEB) , ... June 02, 2020 ... ... (RPM) and telehealth services company that has been serving the healthcare industry for ... website reflecting its expanded virtual and integrated care offerings. , In 2010, RemetricHealth, ...
(Date:5/30/2020)... ... , ... In appreciation for all the dedication and hard work first responders ... a $500 bonus towards the lease or purchase of a new or unused Hyundai ... , To qualify for this offer, individuals must be active as a police officer, ...
(Date:5/28/2020)... ... May 28, 2020 , ... With ... the fall, operators of student housing are scrambling to implement practices that will ... over 37,000 student housing beds on 38 campuses across the country, has researched ...
(Date:5/27/2020)... ... May 27, 2020 , ... ... Pollack, University of Washington Professor of Bioengineering, Founder & Editor of scientific ... & Vapor ( https://www.amazon.com/Fourth-Phase-Water-Beyond-Liquid-ebook/dp/B00N2ASKF2 ) , https://www.voiceamerica.com/episode/123059/the-fourth-phase-of-water , * ...
Breaking Medicine News(10 mins):
(Date:6/3/2020)... ... 03, 2020 , ... Leading the field in specialized dental ... the Dental Entrepreneur Organization (DEO) Virtual Summit June 4-5, 2020. This year’s summit ... Forward.” Progressive Dental Marketing offers years of expertise and advice that is highly ...
(Date:6/2/2020)... ... June 02, 2020 , ... As the ... in response to COVID-19 it is working with its corporate team, its consultants, ... reimbursements, and a host of digital resources. Harmony’s leadership team recognized the extraordinary ...
(Date:6/2/2020)... ... June 02, 2020 , ... Aniara Diagnostica, ... has strengthened its commitment to meeting today’s highest standards for product quality and ... pharmacology, early stages of drug discovery, screening of chemical, cosmetic, alimentary, or agrochemical ...
Breaking Medicine Technology:
Cached News: