HOME >> MEDICINE >> NEWS
Blood cells linked to heart attacks, other inflammatory diseases

SALT LAKE CITY -- It's a case of miscommunication with catastrophic consequences.

Two human blood cells that help fight blood loss, infection, and inflammation are responsible as well for starting a series of molecular events that results in overproduction of Cox-2, an enzyme involved in heart attack, stroke, atherosclerosis, and other inflammatory diseases.

The finding by researchers at the University of Utah and University of South Carolina means scientists may be able to develop drugs to prevent or lessen the severity of inflammatory diseases, such as atherosclerosis and heart attack. Discovery of the signaling mechanism will be invaluable in sorting out the roles Cox-2 plays in those diseases, according to Guy A. Zimmerman, M.D., University of Utah School of Medicine professor of internal medicine, senior author of the study detailing the research.

"This discovery has immediate clinical relevance," said Zimmerman, director of the medical school's Program in Human Molecular Biology and Genetics. "This opens the potential of developing medications for both the prevention of long-term atherosclerosis (clogged arteries) and the acute events of heart attack."

The study, reported in the Journal of Clinical Investigation online, also was led by Dan A. Dixon, a former member of Zimmerman's lab now at South Carolina.

The researchers identified a biochemical signaling pathway between human blood platelets, cells essential for blood clotting, and monocytes, white blood cells the body makes to fight inflammation and infection. But, according to Zimmerman, the biological systems involved in blood clotting and inflammation also are related to a host of human diseases.

The Utah and South Carolina researchers discovered that the blood platelet signals the monocyte two times, triggering production of Cox-2, an enzyme that helps regulate inflammation. But when blood platelets and monocytes get their signals crossed,
'"/>

Contact: Phil Sahm
Phil.Sahm@hsc.utah.edu
801-581-2517
University of Utah Health Sciences Center
5-Oct-2006


Page: 1 2 3

Related medicine news :

1. Blood inflammation plays role in Alzheimers disease
2. Blood-thinning drugs need closer monitoring
3. Blood transfusions from precancerous blood donors do not increase risk of cancer
4. Blood marker helps predict prognosis among those with abdominal infection
5. Blood transfusions raise heart patients infection and death risk -- especially women
6. Blood pressure drugs could help halt pancreatic cancer spread, Jefferson researchers find
7. Blood transfusion-transmitted infections: A global perspective
8. Blood clots can be treated by injections at home
9. Blood pressure variability increases risk for stroke death
10. Blood pressure drugs associated with reduced risk of esophageal, pancreatic and colon cancers
11. Canadian Blood Services scientist invents potential alternative for high-demand blood product

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/17/2019)... , ... July 17, 2019 , ... It took just ... Juan Carlos Martinez, MD, to relieve pressure on the nerves under Amber Walck’s scalp, ... Wescosville, PA woman turned 30 last year, her debilitating headaches began without warning. ...
(Date:7/17/2019)... (PRWEB) , ... July 17, 2019 , ... This past ... the Smiles for Everyone Foundation . Over 50 underserved patients were welcomed at ... , and more while celebrating the summer season. Individuals were referred to the event ...
(Date:7/17/2019)... ... July 17, 2019 , ... The Coalition ... today announced that seven of its member Opioid Treatment Programs (OTPs) at 12 ... and hepatitis C virus (HCV) with the goal of achieving better outcomes through ...
(Date:7/17/2019)... ... July 17, 2019 , ... Dr. Jonathan Zaidan, MD, FACOG, President of Women’s ... Woman Show. The show airs on Wednesday, July 17ths at 7pm. The ... Zaidan and co-host Ann Thomas discuss the challenges that women face when it comes ...
(Date:7/13/2019)... ... July 12, 2019 , ... ... in Clark County. The office is located at 5380 S. Rainbow Blvd., Suite ... Medical Center. , The cancer center is equipped with state-of-the-art medical equipment plus ...
Breaking Medicine News(10 mins):
(Date:7/18/2019)... ... ... Fresh blueberries are now found just a step away from the back ... , These ornamental berry shrubs, which took more than 20 years of breeding to ... in containers, not out of sight in the back yard where unattractive, old-fashion blueberry ...
(Date:7/18/2019)... United Kingdom and MALVERN, Pa. (PRWEB) , ... ... ... series of complimentary seminars aimed at helping pharmaceutical companies reach meeting regulatory guidelines ... What Rules & Regulations are Doing for TMF Health, Phlexglobal will host two ...
(Date:7/17/2019)... ... , ... Soliant, a leading healthcare staffing provider and part of the Adecco ... Most Beautiful Hospital in the U.S. In Soliant’s 10th annual top 20 contest, a ... 96 hospitals nominated. Supporters from across the country nominated and voted for facilities they ...
Breaking Medicine Technology:
Cached News: