HOME >> MEDICINE >> NEWS
Brain inflammation may be friend, not foe, for Alzheimer's patients

Inflammation in the brain may not be so bad after all when it comes to Alzheimers disease.

In the June 1 issue of the Journal of Clinical Investigation, a team of scientists from the University of Rochester Medical Center shows that a key inflammatory regulator, a known villain when it comes to parsing out damage after a stroke and other brain injuries, seems to do the opposite in Alzheimers disease, protecting the brain and helping get rid of clumps of material known as plaques that are a hallmark of the disease.

While many scientists have assumed that inflammation as a result of disease or injury only adds to the brains woes, the new findings show that the opposite may be true when it comes to Alzheimers disease. Perhaps inflammation is playing the role of protector and is acting more like an ambulance crew helping at the site of a road wreck, not causing the crash.

The work suggests that doctors not rush in to turn off molecular events that scientists have widely considered to be detrimental in people with the disease. The findings could also renew efforts to develop a vaccine or other strategies against Alzheimers by engaging the bodys immune system.

The team expected to see the telltale clumps of material known as amyloid plaques, made up of the peptide amyloid beta, worsen. Instead, to the teams surprise, the brains of the mice with IL-1beta stuck in overdrive had only about half

This work provides evidence that blocking all inflammatory responses in Alzheimers disease is not an ideal therapy, added Shaftel. This might hinder processes that are beneficial and part of the bodys adaptive response to fight plaques.

The new findings hinge on a very special mouse that Shaftel spent three years creating with the guidance of his adviser, M. Kerry OBanion, M.D., Ph.D., associate professor of Neurobiology and Anatomy. Shaftel genetically engineered a one-of-a-kind mouse that gives him pinpoint control over bra
'"/>

Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
1-Jun-2007


Page: 1 2 3 4

Related medicine news :

1. Brain-boosting pill alleviates post-chemotherapy fogginess
2. Brain activity reflects differences in types of anxiety
3. Brain research poised to dramatically advance global society
4. Elsevier announces launch of Brain Stimulation
5. Brains scans of symptomatic Gulf War veterans show differences
6. Brain structure changes years before memory loss begins
7. Brain studies reveal the mechanisms of the voluntary control of visual attention
8. Brains can recover from alcoholic damage but patients should stop drinking as soon as possible
9. Brain images show hysteria not an imaginary disorder
10. Brain changes in patients with migraine
11. Brain cell and face perception research wins Eppendorf/Science Prize

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2018)... ... August 14, 2018 , ... Health & hygiene ... Report , which is the largest study of brands based on emotions. In the ... in the Top 10 for the health & hygiene industry were: Listerine, Nivea, Gillette, ...
(Date:8/11/2018)... ... August 10, 2018 , ... TopConsumerReviews.com recently ... , What is gout? This painful, persistent condition originates in the liver and ... levels of uric acid. Other contributing factors may be medication side effects, overweight, ...
(Date:8/9/2018)... (PRWEB) , ... August 09, 2018 , ... Lyme disease ... reported per year skyrocketing to an estimated 329,000 – a 25-fold increase since surveillance ... , Lyme disease can be found all 50 states and the District of Columbia. ...
(Date:8/7/2018)... ... August 07, 2018 , ... Josh Sprague, Founder and CEO ... video preview for the upcoming Leadville 100 MTB. , Accompanied by colleague Marvin ... what he has called “one of the most iconic mountain bike race courses in ...
(Date:8/3/2018)... ... ... On August 2, 2018 the JPML ordered that the Zostavax MDL be assigned ... been litigating Zostavax injuries since 2011. , On July ... thousands of people injured by Zostavax, a vaccine given to adults to prevent shingles. ...
Breaking Medicine News(10 mins):
(Date:8/9/2018)... ... August 09, 2018 , ... National Day ... cbdMD named the exclusive sponsor. , “We’re honored to have been selected as ... embrace for CBD on a national level,” said cbdMD’s Chief Scientific Officer, Dr. ...
(Date:8/7/2018)... ... 07, 2018 , ... Penn State graduate, Dr. Kevin Pauza, ... begun training and certifying spine physicians across the United States on his technique ... at the Weill Cornell Brain and Spine Center in July, and have begun ...
(Date:8/3/2018)... (PRWEB) , ... August 03, 2018 , ... Flexefits, a ... passing H.R. 6199, especially for its allowing participants in Direct Primary Care arrangements to ... by HSAs (capped at $150 per individual and $300 per family per month.) , ...
Breaking Medicine Technology:
Cached News: