HOME >> MEDICINE >> NEWS
Brain inflammation may be friend, not foe, for Alzheimer's patients

Inflammation in the brain may not be so bad after all when it comes to Alzheimers disease.

In the June 1 issue of the Journal of Clinical Investigation, a team of scientists from the University of Rochester Medical Center shows that a key inflammatory regulator, a known villain when it comes to parsing out damage after a stroke and other brain injuries, seems to do the opposite in Alzheimers disease, protecting the brain and helping get rid of clumps of material known as plaques that are a hallmark of the disease.

While many scientists have assumed that inflammation as a result of disease or injury only adds to the brains woes, the new findings show that the opposite may be true when it comes to Alzheimers disease. Perhaps inflammation is playing the role of protector and is acting more like an ambulance crew helping at the site of a road wreck, not causing the crash.

The work suggests that doctors not rush in to turn off molecular events that scientists have widely considered to be detrimental in people with the disease. The findings could also renew efforts to develop a vaccine or other strategies against Alzheimers by engaging the bodys immune system.

The team expected to see the telltale clumps of material known as amyloid plaques, made up of the peptide amyloid beta, worsen. Instead, to the teams surprise, the brains of the mice with IL-1beta stuck in overdrive had only about half

This work provides evidence that blocking all inflammatory responses in Alzheimers disease is not an ideal therapy, added Shaftel. This might hinder processes that are beneficial and part of the bodys adaptive response to fight plaques.

The new findings hinge on a very special mouse that Shaftel spent three years creating with the guidance of his adviser, M. Kerry OBanion, M.D., Ph.D., associate professor of Neurobiology and Anatomy. Shaftel genetically engineered a one-of-a-kind mouse that gives him pinpoint control over bra
'"/>

Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
1-Jun-2007


Page: 1 2 3 4

Related medicine news :

1. Brain-boosting pill alleviates post-chemotherapy fogginess
2. Brain activity reflects differences in types of anxiety
3. Brain research poised to dramatically advance global society
4. Elsevier announces launch of Brain Stimulation
5. Brains scans of symptomatic Gulf War veterans show differences
6. Brain structure changes years before memory loss begins
7. Brain studies reveal the mechanisms of the voluntary control of visual attention
8. Brains can recover from alcoholic damage but patients should stop drinking as soon as possible
9. Brain images show hysteria not an imaginary disorder
10. Brain changes in patients with migraine
11. Brain cell and face perception research wins Eppendorf/Science Prize

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... ... ... your dear friend has cancer? , It’s hard to hear your doctor say the words ... the shock wears off, the questions and fears can be overwhelming. , How should I ... Words are failing me. I’m scared. I want to DO something. , We’ve talked to ...
(Date:8/31/2020)... ... August 31, 2020 , ... Colorado State University ... career-relevant, and affordable online education – is proud to announce its new master’s ... first of its kind in the nation, the 60-credit hour program is designed ...
(Date:8/31/2020)... CHICAGO (PRWEB) , ... August 31, 2020 , ... In ... Chicago West Loop is donating 10 percent of each hotel room booked with ... House Charities® of Chicagoland & Northwest Indiana (RMHC-CNI) , effective immediately. Donations will ...
(Date:8/28/2020)... ... August 28, 2020 , ... Ernst & ... was named an Entrepreneur Of The Year® 2020 Florida Award finalist. Now in ... whose ambitions deliver innovation, growth and prosperity as they build and sustain successful ...
(Date:8/28/2020)... (PRWEB) , ... August 28, 2020 , ... Integrated ... Miami is the first Florida school to deploy its breakthrough Mobile Biodefense Indoor Air ... airborne COVID-19. True North Classical Academy plans to fully reopen equipped with the filtration ...
Breaking Medicine News(10 mins):
(Date:9/2/2020)... WILMINGTON, Mass. (PRWEB) , ... September 02, 2020 ... ... in handheld 1064nm Raman technology, will moderate a roundtable discussion among industry professionals ... The roundtable will be hosted by American Pharmaceutical Review and will ...
(Date:9/2/2020)... ... September 02, 2020 , ... U.S. Dermatology Partners is ... Dr. Lee will work at Bethesda Dermatopathology Lab. , Jonathan Lee, MD ... University of California, Berkley. He went on to receive his M.D. with Honors from ...
(Date:9/1/2020)... ROCHESTER, N.Y. (PRWEB) , ... September 01, 2020 ... ... board-certified dermatologist, and Director of Cosmetics and Laser Surgery at the University of ... and Dermatologic Surgery fellowship at SkinCare Physicians in Boston, with clinical faculty from ...
Breaking Medicine Technology:
Cached News: