However, for postmenopausal women, higher exposure to PAHs at the time of the first birth was associated with increased risk. Neither association was found in women with a history of smoking.
Results of the study were presented earlier this month at the annual meeting of the American Association for Cancer Research held in Anaheim, Calif. Jing Nie, Ph.D., a postdoctoral fellow in epidemiology in UB's School of Public Health and Health Professions is first author on the study.
"There is growing evidence that there may be times in a woman's life when exposures to potential carcinogens may be critical for breast-cancer initiation and development," said Nie. "Our study findings support the hypothesis that exposures in early life contribute to breast-cancer risk."
The study was based on data from the Western New York Exposures and Breast Cancer (WEB) study. All participants were women between the ages of 35 and 79 who lived in Erie or Niagara counties at the time of data collection. Women with primary, histologically confirmed breast cancer served as cases. Controls were randomly selected and matched to cases on age, race and county of residence.
Researchers in the WEB study conducted in-depth personal interviews with study participants to collect data on potential breast-cancer risk factors and a history of where they had lived at
Contact: Lois Baker
University at Buffalo