HOME >> MEDICINE >> NEWS
COX inhibitors may weaken protective qualities of estrogen hormone therapy

PHILADELPHIA -- Researchers from the University of Pennsylvania School of Medicine found in a database study of women heart patients that COX inhibitors such as traditional nonsteroidal anti-inflammatory drugs (NSAIDs) may undermine any purported protection against heart disease in participants taking estrogen therapy. The results were described this week in PLoS Medicine.

Premenopausal women are less susceptible to heart attack and stroke than are males of the same age group, an advantage that is lost after menopause. However, why this happens physiologically is unclear. Despite the cardiovascular advantage of premenopausal women, it has been difficult to identify a cardioprotective effect of taking estrogen in postmenopausal women. The Penn research group recently found in mice that estrogen acts via COX-2dependent prostacyclin, a fat that has a role in limiting blood clotting. Estrogen in this animal model acts via prostacyclin to decrease clotting and oxidative stress in cells and to limit hardening of the arteries.

"We were prompted to perform these studies while exploring the mechanism by which NSAIDs confer a cardiovascular hazard, that is suppression of COX-2 derived prostacyclin" says lead author Garret FitzGerald, MD, Director of the Institute for Translational Medicine and Therapeutics at Penn.

Inhibition of COX-2 by NSAIDs prevents production of prostacyclin. However, as estrogen acts to increase production of prostacyclin, the researchers surmise that the possible positive effects of estrogen therapy on the cardiovascular system may be counteracted by the COX-inhibiting NSAIDs.

To ascertain whether the failure to detect a benefit from estrogen might be partly attributable to a pharmacological interaction between inhibitors of COX-2 and estrogen, the researchers examined the medical records of 1,673 women between 50 and 84 from the United Kingdoms General Practice Research Database who had heart attacks or wh
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
23-May-2007


Page: 1 2

Related medicine news :

1. ACE inhibitors help preserve kidney function in IgA nephropathy
2. Studies provide new evidence on risks associated with Cox-2 inhibitors and NSAIDs
3. Selective serotonin reuptake inhibitors antidepressants and risk of violent behavior
4. COX-2 inhibitors prescribed to reduce gastrointestinal toxicity prior to the market withdrawals
5. First trimester use of ACE inhibitors implicated in birth defects
6. Researchers resolve how COX inhibitors cause heart hazards, and offer alternative treatment strategy
7. ACE inhibitors may reduce death, heart attack and stroke in patients with coronary artery disease
8. COX-2 inhibitors significantly reduce risk of cancer
9. Regular use of selective COX-2 inhibitors decreases risk of breast cancer
10. Race/ethnicity predict lipids, heart-disease risk in HIV-1 patients on protease inhibitors
11. Blocking previously unrecognized links between inflammatory systems could make COX-2 inhibitors safe

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... , ... October 13, 2017 , ... Apple Rehab ... services, staged a mock evacuation of the facility as part of a disaster drill ... Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids ... Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, ... run is geared towards children of all ages; it is a non-competitive, non-timed event, ...
(Date:10/13/2017)... ... 2017 , ... “The Journey: From the Mountains to the Mission Field”: the ... in the Philippines. “The Journey: From the Mountains to the Mission Field” is the ... She has taught all ages and currently teaches a class of ladies at her ...
(Date:10/12/2017)... ... 12, 2017 , ... Planet Fitness, one of the largest and fastest growing ... open a flagship location in Covington, LA at 401 N. U.S. Highway 190, in ... to Office Depot in the Holiday Square shopping center. Its location allows it to ...
(Date:10/12/2017)... ... , ... Asante, a nationally recognized health system in southern ... home health joint venture through an agreement, effective October 1, 2017, to create ... health company with Asante, delivering clinically integrated care, for the past eight years. ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... 2017  According to the Centers for Disease Control and Prevention (CDC), ... PhysicianOne Urgent Care is helping communities across Massachusetts , ... by offering no-cost* flu shots through the end of the month. ... insurance regulations. ... get a flu shot is by the end of October, according to ...
(Date:10/2/2017)... 2, 2017  Eli Lilly and Company (NYSE: ... the third quarter of 2017 on Tuesday, October 24, ... that day with the investment community and media to ... conference call will begin at 9 a.m. Eastern time. ... live webcast of the conference call through a link ...
(Date:10/2/2017)... -- The Rebound mobile app is poised to become a ... of prescription drug addiction. The app empowers users to develop ... down their dosage in a safe, controlled manner while maximizing ... first 100,000 people to sign up will enjoy 3 months ... ...
Breaking Medicine Technology:
Cached News: