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Can an omega-3 fatty acid slow the progression of Alzheimer's disease?

Nutritionists have long endorsed fish as part of a heart-healthy diet, and now some studies suggest that omega-3 fatty acids found in the oil of certain fish may also benefit the brain by lowering the risk of Alzheimers disease. In order to test whether an omega-3 fatty acid can impact the progression of Alzheimers disease, researchers supported by the National Institute on Aging (NIA), part of the National Institutes of Health, will evaluate one in a clinical trial, the gold standard for medical research.

The study will be conducted nationwide by the Alzheimers Disease Cooperative Study (ADCS), a consortium of leading researchers supported by NIA and coordinated by the University of California, San Diego. The trial will take place at 51 sites across the United States and seeks 400 participants age 50 and older who have mild to moderate Alzheimers disease. Joseph Quinn, M.D., associate professor of neurology at Oregon Health and Science University, is directing the study.

Researchers will be evaluating primarily whether the omega-3 fatty acid DHA (docosahexaenoic acid), taken over many months, slows the progression of both cognitive and functional decline in people with mild to moderate Alzheimers. During the 18-month clinical trial, investigators will measure the progress of the disease using standard tests for functional and cognitive change.

The evidence to date in observational and animal studies on omega-3 fatty acids and Alzheimers disease warrants further evaluation in a rigorous clinical trial, says NIA Director Richard J. Hodes, M.D. This study is one of a number we are undertaking in the next few years through the ADCS to test compounds that might play a role in preventing or delaying the symptoms of this devastating disease.

By participating in this study, volunteers will make an invaluable contribution to Alzheimers disease research progress, says Quinn, the studys principal investigator. We are indebted to th
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Contact: Linda Joy
nianews3@mail.nih.gov
301-496-1752
NIH/National Institute on Aging
10-May-2007


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