HOME >> MEDICINE >> NEWS
Cancer drug extends cognitive function in patients with brain metastases

AUSTIN, Texas--The drug Xcytrin, based on a molecule developed by chemists at The University of Texas at Austin, shows significant promise in prolonging cognitive function in patients with non-small cell lung cancer that has metastasized to the brain.

This result, presented at the annual meeting of the American Society of Clinical Oncology on June 5, supports Pharmacylics, Inc.'s recent decision to file a New Drug Application with the U.S. Food and Drug Administration.

In a Phase 3 trial, Xcytrin was delivered in conjunction with whole brain radiation treatment to patients with non-small cell lung cancer that had spread to the brain. Xcytrin significantly prolonged the time to neurologic progression, which is described as a change in mental status, vision and muscle strength associated with the progression of brain cancers.

"In conjunction with radiation, Xcytrin enhances cancer cell death," said Dr. Jonathan Sessler, professor of chemistry and biochemistry and co-founder of Pharmacyclics (Sunnyvale, Calif., PCYC). "Radiation puts stress on the cells and the drug puts further stress on the cells. Add them together and the cells start to die."

More than 500 patients from North America, France and Australia participated in this Pharmacyclics trial combining Xcytrin injection with whole brain radiation. In North America, patients receiving the treatment experienced neurologic progression 16 months later than patients not receiving the treatment.

Xcytrin (motexafin gadolinium) is based on texaphyrin molecules developed in Sessler's lab. Texaphyrins are large, "Texas-sized" versions of porphyrins, which are highly pigmented molecules responsible for the color of red blood cells. Texaphyrins localize to cancer cells and disrupt cellular metabolism and energy production, weakening or destroying the cells. The molecules are relatively non-toxic to normal cells.

Sessler's texaphyrins were designed to hold heavy metals like gad
'"/>

Contact: Lee Clippard
lclippard@mail.utexas.edu
512-232-0675
University of Texas at Austin
5-Jun-2006


Page: 1 2

Related medicine news :

1. American Cancer Society to hold third annual Virtual Relay For Life in Second Life
2. Cancer research summaries
3. Cancer on the agenda of the Portuguese EU Council Presidency
4. Tony Hunter receives Robert. J. and Claire Pasarow Award for Cancer Research
5. OHSU Cancer Institute shows findings of immunotherapy vaccine in prostate cancer patients
6. OHSU Cancer Institute, VA researchers find way to identify which men need a second biopsy
7. OHSU Cancer Institute researcher identifies protein marker for prostate cancer survival
8. Ireland Cancer Center researcher lays out benefits of aspirin to prevent colon cancer
9. Mayo Clinic Cancer Center researcher finds mold by-product kills multiple myeloma
10. Margaret Foti receives AACR Award for Leadership and Extraordinary Achievements in Cancer Research
11. Cancer-fighting foods, supplements explored in day-long symposium, March 25

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... ... 2020 , ... Colorado State University Global (CSU Global) – ... education – is proud to announce its new master’s degree in Military ... in the nation, the 60-credit hour program is designed to provide students with ...
(Date:8/31/2020)... ... August 31, 2020 , ... In an effort to give back ... donating 10 percent of each hotel room booked with a special new rate code ... Northwest Indiana (RMHC-CNI) , effective immediately. Donations will be applied to any room ...
(Date:8/28/2020)... Fla. (PRWEB) , ... August 28, 2020 , ... ... Forcura’s Founder & CEO Craig Mandeville was named an Entrepreneur Of The Year® ... Year program honors entrepreneurial business leaders whose ambitions deliver innovation, growth and prosperity ...
(Date:8/28/2020)... ... ... Integrated Viral Protection (IVP Air) today announced that the True North ... Biodefense Indoor Air Protection System that is the first system designed and proven to ... with the filtration system on September 8th. , The IVP Air S1 model ...
(Date:8/27/2020)... ... August 27, 2020 , ... The team at Sikara ... and wellness retreat. The practice is centered on results and providing the ultimate ... , Designed to be a sanctuary for total body renewal and aesthetic revitalization, ...
Breaking Medicine News(10 mins):
(Date:8/31/2020)... ... August 31, 2020 , ... ... Disinfecting - a broad-spectrum sanitization, disinfection and deodorization provider - is proud ... door-to-door sanitizing and disinfecting services for businesses and residents throughout the area. , ...
(Date:8/28/2020)... ... August 28, 2020 , ... ... aesthetic beauty, bringing a unique perspective and approach. Armed with her qualifications from ... out to share her knowledge of the human body with the nation and ...
(Date:8/27/2020)... ... August 27, 2020 , ... Bleep LLC, maker of the DreamPort ... patient, is the company’s new spokesperson. , “In my line of work, a good ... found the Bleep DreamPort it was a Bleeping no brainer for me,” said Jensen. ...
Breaking Medicine Technology:
Cached News: