HOME >> MEDICINE >> NEWS
Cancer immunoresistance linked to loss of tumor suppressor gene

Cancer immunoresistance may be partially due to loss of a well-known tumor suppressor gene, according to new research led by Andrew T. Parsa, MD, PhD, assistant professor of neurological surgery at the University of California, San Francisco.

The findings are reported today (December 10) online and are scheduled to appear in the January issue of Nature Medicine.

It has been known for a long time that cancer cells have many different ways to avoid the immune system, including the common strategies of hiding proteins that are normally expressed on the cell surface or making proteins that act to suppress immune responses, according to Parsa. Some researchers believe that immunoresistance may contribute to cancer progression and development, he added.

Over the past four years, Parsas lab has focused on trying to understand how specific mutations associated with high grade glioma correlate with immunoresistance. Malignant glioma is among the deadliest types of brain cancer for which there currently is no effective treatment.

My colleague James Waldron and I began screening different cell lines for mutations and trying to match these mutations up with proteins that suppress the immune system, Parsa said.

The researchers began to see an interesting trend. Glioma cells with mutation in a specific gene called the phosphatase and tensin homolog gene, or PTEN, seemed more resistant to the immune system than glioma cells with normal PTEN function. Determining the mechanism responsible for the immunoresistance proved more difficult.

Fortunately, Russ Piepers lab here at UCSF had developed a model that took normal human astrocytes and made them act like a malignant glioma. This allowed us to study the effects of PTEN mutation in a very well controlled manner, Parsa said.

In glioma patients who have lost PTEN function, the tumor cells were found to express high levels of B7-H1, a protein that c
'"/>

Contact: Carol Hyman
chyman@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
10-Dec-2006


Page: 1 2

Related medicine news :

1. American Cancer Society to hold third annual Virtual Relay For Life in Second Life
2. Cancer research summaries
3. Cancer on the agenda of the Portuguese EU Council Presidency
4. Tony Hunter receives Robert. J. and Claire Pasarow Award for Cancer Research
5. OHSU Cancer Institute shows findings of immunotherapy vaccine in prostate cancer patients
6. OHSU Cancer Institute, VA researchers find way to identify which men need a second biopsy
7. OHSU Cancer Institute researcher identifies protein marker for prostate cancer survival
8. Ireland Cancer Center researcher lays out benefits of aspirin to prevent colon cancer
9. Mayo Clinic Cancer Center researcher finds mold by-product kills multiple myeloma
10. Margaret Foti receives AACR Award for Leadership and Extraordinary Achievements in Cancer Research
11. Cancer-fighting foods, supplements explored in day-long symposium, March 25

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/6/2016)... ... 06, 2016 , ... 'Tis the season for family, festivity, food and fun! ... the season when eating healthy, staying active, and taking medication and doing daily foot ... do. , "Shopping trips, parties and family gatherings can take their toll on ...
(Date:12/6/2016)... , ... December 06, 2016 , ... ... , the only authorized OSHA Training Institute Education Center headquartered in Northern California, ... program focused on providing occupational safety and health training to public sector employees. ...
(Date:12/5/2016)... ... December 05, 2016 , ... Edward Buckingham MD ... the arrival of the newest Sciton laser in January 2017. The Halo is ... non-ablative and ablative wavelengths for exceptional results. Outperforming more traditional lasers, the innovative ...
(Date:12/5/2016)... ... December 05, 2016 , ... Researchers at Johns Hopkins ... growing brains of young athletes. Over the course of three years, researchers will study ... mouth guards. The mouth guards, equipped with special sensors, will track the location and ...
(Date:12/5/2016)... ... December 05, 2016 , ... ... provide alerting technology to Central Illinois Health Information Exchange (CIHIE) using its ... funds as the sole sub-recipient participating with the Illinois Health Information Exchange ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... Dec. 5, 2016 Spain Glaucoma Surgery Devices ... report, "Spain Glaucoma Surgery Devices Market Outlook to 2022", ... Devices market. The report provides value, in millions of ... within market segements - Canaloplasty Micro Catheters and Glaucoma ... and distribution shares data for each of these market ...
(Date:12/5/2016)... Calif. , Dec. 5, 2016 Sangamo BioSciences, ... genome editing, announced the presentation of preclinical and manufacturing data ... at the 58 th Annual Meeting of the American ... Diego, CA , from December 3-6, 2016. ... of hemophilia A which we believe is highly competitive, and ...
(Date:12/5/2016)... 2016  Cornerstone Pharmaceuticals, Inc., a privately held, ... two Phase I trials evaluating its lead compound, ... meeting of the American Society of Hematology (ASH) ... The two datasets show encouraging efficacy and safety ... and T-cell non-Hodgkin,s lymphoma (T-cell NHL), respectively, supporting ...
Breaking Medicine Technology:
Cached News: