Cedars-Sinai researchers discover treatment for deadly brain tumors and infections

In a study published in the March 15 issue of The Journal of Immunology, researchers at Board of Governors' Gene Therapeutics Research Institute at Cedars-Sinai Medical Center have developed a way to overcome immune privilege in the brain to eradicate potentially deadly brain tumors such as glioblastoma multiforme and other types of brain infections.

Brain tumors account for 85 to 90 percent of all primary central nervous system tumors. Of those tumors, almost 40 percent are either the deadly glioblastoma multiforme or anaplastic astrocytomas. Each year about 19,000 people in the United States are diagnosed with primary brain cancers, and close to 70 percent of those diagnosed will not survive more than five years. In addition, approximately 150,000 Americans a year are diagnosed with metastatic brain tumors, cancer that has spread into the brain from another part of the body.

"We have developed a novel gene therapy strategy to modify the brain microenvironment which will allow us to overcome immune privilege in the brain and improve the lives of those who are suffering with life-threatening diseases such as brain cancer or brain infections," said Maria Castro, Ph.D., co-director of the Board of Governors' Gene Therapeutics Research Institute at Cedars-Sinai Medical Center and the principal investigator of the study.

The brain's blood-brain barrier and lack of a drainage system means that the organ has immune privilege and therefore cannot mount a defense against cancer or other infectious diseases localized in it. Once activated, immune cells can cross the blood-brain barrier and attack pathogens or tumors; however, it is not possible to mount an effective immune response from the brain itself because it lacks antigen presenting cells. In the study published in the Journal of Immunology, researchers lead by Dr. Castro and Dr. Pedro Lowenstein found a way of engineering the brain's microenvironment to induce the migration of antigen pre

Contact: Cynthia Harding
Cedars-Sinai Medical Center

Page: 1 2 3

Related medicine news :

1. Cedars-Sinai researchers present new endocrine findings at 2 international conferences
2. Cedars-Sinai endocrine researchers to discuss gene that may be linked to polycystic ovary syndrome
3. Obesity leads to more aggressive ovarian cancer, Cedars-Sinai research shows
4. Pauletta and Denzel Washington to present Cedars-Sinai neuroscience scholarships June 7
5. Potential prostate cancer treatment improvements discovered by researchers at Cedars-Sinai
6. Cedars-Sinai researchers demonstrate a new way to switch therapeutic genes on and off
7. Cedars-Sinai medical tipsheet for December 2005
8. Cedars-Sinais live donor liver transplant program receives unos-approved designation
9. Cedars-Sinai medical tipsheet for June 2005
10. Stanford researchers find culprit in aging muscles that heal poorly
11. UCLA researchers awarded $9M contract for study identifiying antibiotic treatment for MRSA

Post Your Comments:

(Date:7/10/2020)... ... July 09, 2020 , ... CellTrak, the leading electronic ... that Ohio Department of Medicaid has awarded CellTrak Phase 2 EVV certification as ... already rely on CellTrak for EVV – both as a point-of-care solution and ...
(Date:7/10/2020)... ... ... Ziegler, a specialty investment bank, is pleased to announce the successful closing of ... (Beacon Hill). The Series 2020 Bank Bonds include a $9,800,000 long-term component with ... be retired with initial entrance fees from the Project (detailed below). , ...
(Date:7/10/2020)... MANHATTAN BEACH, Calif. (PRWEB) , ... July 10, 2020 , ... ... training , today announced a new training course for managers on the Family and ... expands the FMLA with paid sick and family leave provisions related to COVID-19. ...
(Date:7/7/2020)... ... 2020 , ... Mediaplanet recently launched an awareness initiative to inspire more people ... field into the spotlight and, as a result, the Bureau of Labor Statistics predicts ... South University — which offers a Master’s in Public Health degree program ...
(Date:7/7/2020)... (PRWEB) , ... July 07, 2020 , ... Great Point ... portfolio company, Board of Directors has appointed Rick Katz as Vice President of Business ... found the best individual to assume this leadership role for the organization," said Adam ...
Breaking Medicine News(10 mins):
(Date:7/10/2020)... SOUTH SAN FRANCISCO, Calif. (PRWEB) , ... ... ... American Pharmaceutical Review , the leading review of business and technology ... resource to cover the development and manufacturing of the highest quality pharmaceutical ...
(Date:7/7/2020)... ... July 07, 2020 , ... To support those on the ... Change (WGC), will be providing meals to the employees of Southern Nevada Health District. ... throughout Las Vegas on Wednesday, July 8th. , When asked why the Women of ...
(Date:7/7/2020)... HALIFAX, Nova Scotia (PRWEB) , ... July 07, ... ... 2020 rebrand. Established in 2017, the company began as a hair service provider. ... for both in-office and work-from-home employees. Bright’s expanded offering includes beauty amenities as ...
Breaking Medicine Technology:
Cached News: