HOME >> MEDICINE >> NEWS
Cell stress protein linked to aggressive breast cancer

A groundbreaking study led by Northwestern University researchers has demonstrated that a protein called alphaB-crystallin, which normally protects cells from stress damage, triggers events that may cause breast cancer when overactive.

Breast cancer is the most common cancer in women and is responsible for over 400,000 deaths annually in women throughout the world. Most of these deaths are the result of aggressive breast tumors that often fail to respond to current treatments.

The researchers found that women whose breast tumors express the alphaB-crystallin protein have a shorter survival, suggesting that alphaB-crystallin may be a useful molecular marker to identify women with aggressive breast cancer and to develop new targeted cancer therapies.

The study, which was published in the January issue of the Journal of Clinical Investigation, was led by Vincent L. Cryns, M.D., associate professor of medicine and director of the Cell Death Regulation Laboratory at Northwestern University Feinberg School of Medicine, and a researcher at The Robert H. Lurie Comprehensive Cancer Center of Northwestern University.

Cryns and colleagues found that introducing the alphaB-crystallin gene into non-cancerous breast cells transformed them into breast cancer cells. These experiments took advantage of a powerful technique to grow breast cells as three-dimensional (3D) gland-like structures that are similar to those present in the normal breast. However, when the researchers introduced alphaB-crystallin into non-cancerous breast cells, the cells started growing uncontrollably and formed enlarged 3D masses that resemble breast tumors.

The experiments were conducted by Jose V. Moyano, a post-doctoral fellow in the Cryns lab, who was lead author on the study.

"Basically, breast cancer cells have hijacked alphaB-crystallin, a protein that normally protects cells against stress injury and death, and used it to promote their uncontrolled
'"/>

Contact: Elizabeth Crown
e-crown@northwestern.edu
312-503-8928
Northwestern University
4-Jan-2006


Page: 1 2

Related medicine news :

1. Reductive stress linked to heart disease
2. New study shows Rescue Remedy is an effective all-natural stress, anxiety reliever
3. Reduced greenhouse gas emissions required to avoid dangerous increases in heat stress
4. Blocking stress protein decreases Alzheimers peptide in mice
5. Improving communication with families of dying patients reduces stress, anxiety and depression
6. Post-traumatic stress disorder 10 times higher in New Orleans than in the general public
7. Weill Cornell researchers use Virtual Iraq simulation to study post-traumatic stress disorder
8. Cognitive therapy can reduce post-traumatic stress in survivors of terrorist attacks
9. Biofeedback on abnormal mechanics lowers risk for stress fractures, pain under kneecap
10. Pistachios may calm acute stress reaction
11. Dua anti-reflux stent relieves GI upper cancer distress

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/3/2020)... TEMPE, Ariz. (PRWEB) , ... August 03, 2020 ... ... – announced today the launch of its newest product, CoverageCoach. The site provides ... understand, compare, and purchase insurance products. The company sees CoverageCoach as an important ...
(Date:7/31/2020)... ... July 31, 2020 , ... Today Hinge Health, ... expansion of clinical & technical capabilities to cover the full continuum of care ... joint health solution. , Currently, employers interested in truly solving their MSK ...
(Date:7/22/2020)... ... July 22, 2020 , ... Ocean Tomo Transactions, ... matter and manufacturing processes from Brock University for jurisdictions throughout North America, Europe ... by Brock University provides the manufacturing processes of novel opioid related compositions for ...
(Date:7/18/2020)... ... July 17, 2020 , ... “Frozen.” It’s not simply the title ... – oftentimes for unknown reasons – resulting in stiffness, persistent pain and loss of ... in treating problems of the upper limbs and joints and founder and chief medical ...
(Date:7/18/2020)... ... July 18, 2020 , ... When the federal government extended the ... for small and some bigger businesses to obtain a PPP loan. But the biggest ... “GIG Economy” do not realize they are eligible. , While 4.9 million companies ...
Breaking Medicine News(10 mins):
(Date:7/22/2020)... , ... July 22, 2020 , ... ... the nation’s top healthcare companies and part of WPP (NYSE:WPP), has continued its ... Media Investment. , As the agency ventures further into healthcare consumer media, Warren ...
(Date:7/10/2020)... ... July 10, 2020 , ... COMPLIANCY ... HIPAA Compliance for Business Associates. Business associates create, receive, transmit, store, and maintain ... business associates are required to be HIPAA compliant, ensuring the confidentiality, integrity, and ...
(Date:7/7/2020)... ... July 07, 2020 , ... CHESS Health, the leading ... leading comprehensive platform for online education on mental health, substance use, and suicide ... Use Disorder (SUD) patients throughout each step of the treatment process. , “We ...
Breaking Medicine Technology:
Cached News: