HOME >> MEDICINE >> NEWS
Cell stress protein linked to aggressive breast cancer

A groundbreaking study led by Northwestern University researchers has demonstrated that a protein called alphaB-crystallin, which normally protects cells from stress damage, triggers events that may cause breast cancer when overactive.

Breast cancer is the most common cancer in women and is responsible for over 400,000 deaths annually in women throughout the world. Most of these deaths are the result of aggressive breast tumors that often fail to respond to current treatments.

The researchers found that women whose breast tumors express the alphaB-crystallin protein have a shorter survival, suggesting that alphaB-crystallin may be a useful molecular marker to identify women with aggressive breast cancer and to develop new targeted cancer therapies.

The study, which was published in the January issue of the Journal of Clinical Investigation, was led by Vincent L. Cryns, M.D., associate professor of medicine and director of the Cell Death Regulation Laboratory at Northwestern University Feinberg School of Medicine, and a researcher at The Robert H. Lurie Comprehensive Cancer Center of Northwestern University.

Cryns and colleagues found that introducing the alphaB-crystallin gene into non-cancerous breast cells transformed them into breast cancer cells. These experiments took advantage of a powerful technique to grow breast cells as three-dimensional (3D) gland-like structures that are similar to those present in the normal breast. However, when the researchers introduced alphaB-crystallin into non-cancerous breast cells, the cells started growing uncontrollably and formed enlarged 3D masses that resemble breast tumors.

The experiments were conducted by Jose V. Moyano, a post-doctoral fellow in the Cryns lab, who was lead author on the study.

"Basically, breast cancer cells have hijacked alphaB-crystallin, a protein that normally protects cells against stress injury and death, and used it to promote their uncontrolled
'"/>

Contact: Elizabeth Crown
e-crown@northwestern.edu
312-503-8928
Northwestern University
4-Jan-2006


Page: 1 2

Related medicine news :

1. Reductive stress linked to heart disease
2. New study shows Rescue Remedy is an effective all-natural stress, anxiety reliever
3. Reduced greenhouse gas emissions required to avoid dangerous increases in heat stress
4. Blocking stress protein decreases Alzheimers peptide in mice
5. Improving communication with families of dying patients reduces stress, anxiety and depression
6. Post-traumatic stress disorder 10 times higher in New Orleans than in the general public
7. Weill Cornell researchers use Virtual Iraq simulation to study post-traumatic stress disorder
8. Cognitive therapy can reduce post-traumatic stress in survivors of terrorist attacks
9. Biofeedback on abnormal mechanics lowers risk for stress fractures, pain under kneecap
10. Pistachios may calm acute stress reaction
11. Dua anti-reflux stent relieves GI upper cancer distress

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cell stress protein linked aggressive breast cancer

(Date:6/19/2013)... Children had half as many emergency department visits if ... five or more days a week, according to new ... Hospital and Johns Hopkins University. , The new study ... of Pediatrics and will be presented at the ... important step in understanding where primary care practices and ...
(Date:6/19/2013)... are increasingly common on college campuses, but are ... up"? A new study by researchers with The ... published online by the Archives of Sexual ... behaviors associated with sexual hookups, particularly among first-year ... negative emotional and physical health outcomes as a ...
(Date:6/19/2013)... block the body,s system for repairing damage to the ... unlikely as it may seem, those compounds are sparking ... driven by a mutation in BRCA, a gene that ... the mutation. The compounds, termed PARP inhibitors, are the ... of Chemical & Engineering News . C&EN is ...
(Date:6/19/2013)... Moffitt Cancer Center and colleagues at Louisiana State University ... that require immediate therapy. It relies on understanding the ... is to better predict a prostate cancer,s aggressiveness to ... published in the online journal PLOS ONE ... accounts for 20 percent of all cancers and 9 ...
(Date:6/19/2013)... Alternatives, a revolutionary new treatment facility located ... drugs while allowing them to continue drinking alcohol. Drs. ... believe that abstinence-only approaches force people to wait until ... this approach hurts instead of helping. It is ... need treatment for addiction but only 3 million seek ...
Breaking Medicine News(10 mins):Health News:Extended primary care office hours might help keep kids out of the emergency department 2Health News:Why are some college students more likely to 'hook up'? 2Health News:Moffitt Cancer Center researchers identify genetic variants predicting aggressive prostate cancers 2Health News:Top L.A. Addiction Experts Assert That an Abstinence-Only Approach to Addiction Keeps 85% of Addicts From Seeking Treatment 2Health News:Top L.A. Addiction Experts Assert That an Abstinence-Only Approach to Addiction Keeps 85% of Addicts From Seeking Treatment 3
(Date:6/19/2013)... /PRNewswire-iReach/ -- Today leading web researchers Change Sciences Group ... web sites for usability, engagement, and conversion. The rankings ... which compares how people experience sites with competitors and ... The top three performers are easier to use, more ... performers have usability problems, lack aspects of design that ...
(Date:6/19/2013)... , June 19, 2013 Today MedeAnalytics, ... introduced the next-generation of its Employer Group ... health plans to provide their employer groups an ... factors, medical and prescription drug claims, network utilization, ... http://photos.prnewswire.com/prnh/20100621/SF23660LOGO ) "Employer Group ...
(Date:6/18/2013)... Quebec , June 18, 2013 Valeant ... TSX: VRX) (the "Company") announced today that VPII Escrow ... the Company, has launched its offer of approximately $3.2 ... "Notes").  The Notes will be due in 2021 and ... The Company intends to use the net proceeds ...
Breaking Medicine Technology:Sunovion tops new Change Sciences User Experience Rankings for Pharmaceutical Industry while McNeil-PPC ranks worst overall 2MedeAnalytics Introduces Next-Generation Employer Group and Individual Business Analytics Solution 2Valeant Pharmaceuticals Announces Launch Of Private Offering Of Senior Notes 2Valeant Pharmaceuticals Announces Launch Of Private Offering Of Senior Notes 3
Cached News: