HOME >> MEDICINE >> NEWS
Certain combination therapy found more effective for treating malaria in African children

Ugandan children who received the combination therapy of artemether-lumefantrine experienced a lower rate of treatment failure compared to other combination therapies, according to a study in the May 23/30 issue of JAMA, a theme issue on malaria.

Malaria is one of the leading causes of death in children in Africa. One of the reasons the control of malaria has been difficult is because of increasing resistance to some drugs, leading to changes in antimalarial treatment recommendations, according to background information in the article. Combination therapies have replaced monotherapies as the recommended treatments for uncomplicated malaria. However, it is not clear which treatment regimens are most effective.

Grant Dorsey, M.D., Ph.D., of the University of California, San Francisco, and colleagues evaluated the three leading available combination regimens for treating uncomplicated falciparum malaria (one of the most severe types of malaria, with one of the highest death rates) and compared their efficacy, safety, and tolerability. The clinical trial, conducted between November 2004 and June 2006, included 601 healthy children (age 1-10 years) from an urban community in Kampala, Uganda. The children were randomized to receive 1 of 3 combination therapies (amodiaquine plus sulfadoxine-pyrimethamine, amodiaquine plus artesunate, or artemether-lumefantrine) when they were diagnosed with their first episode of uncomplicated malaria. The participants were followed-up for 13 to 19 months.

Of enrolled children, 329 of 601 were diagnosed with at least 1 episode of uncomplicated malaria, and 687 episodes of Plasmodium falciparum malaria were treated with study drugs. The risk of treatment failure after 28 days of follow-up was 26.1 percent with amodiaquine plus sulfadoxine-pyrimethamine, 17.4 percent for amodiaquine plus artesunate, and 6.7 percent for artemether-lumefantrine. When only treatment failures caused by recrudescent (becoming ac
'"/>

Contact: Wallace Ravven
415-502-1332
JAMA and Archives Journals
22-May-2007


Page: 1 2

Related medicine news :

1. Certain types of cancer becoming more common, while rates of others decreasing
2. Certain acne treatment does not increase symptoms of depression in adolescents
3. Certain weight control behaviors may precipitate obesity among adolescent girls
4. Phase II study shows combination improves survival of metastatic melanoma patients
5. To get blood pressure under control, combination of medicines may be best
6. Drug/intervention combinations offer benefit in severe CVD
7. Scripps research combination therapy obliterates new vessel growth in tumors and retinopathy
8. Drug combination slows progression of treatment resistant bone marrow cancer
9. Drug combination proves effective against myeloma in Phase I trial
10. Drug combination could reduce risk of severe asthma attacks
11. Transplant patients keep their new kidney longer with a CellCept-based drug combination

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of the ... national organization of elder law and special needs planning attorneys. “Membership in ElderCounsel helps ... provides a forum to network with elder law attorneys nationwide,” said Somekh. , ...
(Date:10/13/2017)... ... 2017 , ... Many families have long-term insurance that covers care for a ... waiver for care if the client has a cognitive impairment diagnosis. , “What ... is often waived, so the benefits from their insurance start immediately,” said Mechell Vieira, ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... ... 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of ... popular and least understood books in the Holy Scriptures, Revelation. The Book of Revelation ... scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Software Development, has been awarded a contract by the Center for Medicare and ... aims to accelerate the enterprise use of Agile methodologies in a consistent and ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... received FDA 510(k) clearance in May 2017 for its highly anticipated ... for endoscopy environments. An innovative secondary monitor solution, ZeroWire Mobile ... the improvement of patient outcomes, procedural efficiency, and the lowering of ... ... By ...
(Date:10/7/2017)... 6, 2017   Provista, a proven leader ... billion in purchasing power, today announced a new resource ... The Newsroom is the online home for case ... expert bios, news releases, slideshows and events. ... wealth of resources at their fingertips, viewers can also ...
(Date:10/4/2017)... , Oct. 4, 2017  South Korean-based healthcare product ... training aide "cprCUBE" on Kickstarter. The device will educate ... cardiac arrests with better efficiency compared to the dated ... real-time feedback on efficacy of the compression for a ... has a goal to raise $5,000. ...
Breaking Medicine Technology:
Cached News: