Changes in brain receptors linked to seizures and anxiety during the menst...( The changes may spark seizures in wom...)

Changes in brain receptors linked to seizures and anxiety during the menstrual cycle

The changes may spark seizures in women with catamenial epilepsy and may lead to the increased anxiety women experience during PMDD, according to the researchers who also filed a patent for the potential new therapies.

The next step will be to determine the precise mechanisms behind these changes, Mody said. "We have to find the molecular identities of the players responsible for changing the number of these receptors on the surface of nerve cells," he said.

Also, researchers need to learn if similar mechanisms operate in humans as well.

The other researchers were Jamie L. Maguire, Ph.D., postdoctoral fellow; Brandon M. Stell, Ph.D., a recent graduate of the UCLA Molecular, Cellular and Integrative Physiology Interdepartmental Graduate Program, and Dr. Mahsan Rafizadeh, research associate, all from the departments of neurology and physiology at the David Geffen School of Medicine at UCLA.

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Contact: Enrique Rivero
erivero@mednet.ucla.edu
310-794-2273
University of California - Los Angeles
15-May-2005

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Changes in brain receptors linked to seizures and anxiety during the menst...( The changes may spark seizures in wom...),Health