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Chemotherapy given directly to the liver improves survival for patients with colorectal cancer

Alexandria, VA--A new study shows that patients whose colorectal cancer has spread to the liver who received an approach called hepatic arterial infusion (HAI)-- the administration of chemotherapy directly to the liver through a pump in the abdomen--fare better than those who received traditional, intravenous chemotherapy. Researchers found that the patients on the HAI therapy lived longer and had better quality of life than those receiving systemic therapy. The study will be published online February 27 in the Journal of Clinical Oncology.

"This study demonstrates that hepatic arterial infusion therapy extends survival and improves quality of life in patients with colorectal cancer that has spread to the liver," said Nancy E. Kemeny, MD, an Attending Physician in the Department of Medicine at Memorial Sloan-Kettering Cancer Center and the study's lead author. "These positive findings are particularly important, given that metastasis to the liver occurs in 60% of patients with metastatic colorectal cancer, and most patients with these liver tumors eventually die of their disease."

Several smaller studies have previously compared outcomes of HAI with systemic chemotherapy, but this is the first large study that had no crossover between the groups, meaning that none of the patients in the systemic group received HAI therapy.

In the multi-institutional trial by researchers from the Cancer and Leukemia Group B and the Eastern Cooperative Oncology Group, 135 patients were assigned randomly to receive either HAI or systemic chemotherapy. All of the patients needed to undergo surgical removal (resection) of their primary tumors in the colon or rectum before initiating chemotherapy. Patients receiving HAI then underwent a surgical procedure to have a chemotherapy pump inserted into their abdomen. (This procedure can sometimes be done laparoscopically.)

Researchers found that patients receiving HAI lived longer than those receiving systemic ch
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Contact: Danielle Potuto
potutod@asco.org
703-568-1275
American Society of Clinical Oncology
27-Feb-2006


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