HOME >> MEDICINE >> NEWS
Chemotherapy more effective when given before breast cancer surgery

Giving chemotherapy to women with operable breast cancer before they have surgery not after helps physicians pin down the best treatment regimen and can reduce the extent of surgery, according to a new systematic review.

Preoperative chemotherapy reduced chemo-related infections by 4 percent and the need for mastectomies by 17 percent when compared to postoperative chemotherapy, found reviewers led by Sven Mieog, M.D., of Leiden University Medical Center in the Netherlands.

Mieog and colleagues looked at 14 studies that included 5,500 women with operable breast cancer. Half of the women received preoperative chemotherapy and the rest received chemotherapy after surgery.

The data revealed a higher cancer recurrence rate in women who had chemotherapy before surgery, although this did not affect survival rates, which were similar for both groups.

"Ten studies reported overall survival data on 4,620 women involving 1,139 estimated deaths," the authors write. "There was no detectable difference between preoperative and postoperative chemotherapy."

The review appears in the current issue of The Cochrane Library, a publication of The Cochrane Collaboration, an international organization that evaluates research in all aspects of health care. Systematic reviews draw evidence-based conclusions about medical practice after considering both the content and quality of existing trials on a topic.

One reason for giving chemotherapy first is to shrink tumors before surgery, the researchers say.

Moreover, preoperative chemotherapy allows doctors to see if a tumor is resistant to a particular drug and thus adjust the dose or switch to another drug after surgery. The patient might avoid toxic side effects while getting another chance to receive appropriate systemic treatment, Mieog said.

After surgery, doctors can no longer gauge chemotherapy's effect on tumor size.

"Concerns could be raise
'"/>

Contact: Lisa Esposito
hbns-editor@cfah.org
Center for the Advancement of Health
10-May-2007


Page: 1 2 3

Related medicine news :

1. Chemotherapy with bevacizumab increases risk of blood clots in arteries
2. Chemotherapy may enhance the effectiveness of brain tumor vaccines
3. Chemotherapy temporarily affects the structures of the human brain
4. Chemotherapy gel may fight breast cancer and reduce breast deformity
5. Chemotherapy given directly to the liver improves survival for patients with colorectal cancer
6. Chemotherapy after surgery extends survival for patients with advanced endometrial cancer
7. Chemotherapy errors rare, but have potential for serious consequences
8. Chemotherapy for brain tumors is boosted after vaccine targets resistance-related antigen
9. Chemotherapy options improve for patients with advanced colorectal cancer
10. New treatment effective in counteracting cocaine-induced symptoms
11. Osteoporosis screening and treatment may be cost-effective for selected older men

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of the ... national organization of elder law and special needs planning attorneys. “Membership in ElderCounsel helps ... provides a forum to network with elder law attorneys nationwide,” said Somekh. , ...
(Date:10/13/2017)... ... 2017 , ... Many families have long-term insurance that covers care for a ... waiver for care if the client has a cognitive impairment diagnosis. , “What ... is often waived, so the benefits from their insurance start immediately,” said Mechell Vieira, ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... ... 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of ... popular and least understood books in the Holy Scriptures, Revelation. The Book of Revelation ... scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Software Development, has been awarded a contract by the Center for Medicare and ... aims to accelerate the enterprise use of Agile methodologies in a consistent and ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... received FDA 510(k) clearance in May 2017 for its highly anticipated ... for endoscopy environments. An innovative secondary monitor solution, ZeroWire Mobile ... the improvement of patient outcomes, procedural efficiency, and the lowering of ... ... By ...
(Date:10/7/2017)... 6, 2017   Provista, a proven leader ... billion in purchasing power, today announced a new resource ... The Newsroom is the online home for case ... expert bios, news releases, slideshows and events. ... wealth of resources at their fingertips, viewers can also ...
(Date:10/4/2017)... , Oct. 4, 2017  South Korean-based healthcare product ... training aide "cprCUBE" on Kickstarter. The device will educate ... cardiac arrests with better efficiency compared to the dated ... real-time feedback on efficacy of the compression for a ... has a goal to raise $5,000. ...
Breaking Medicine Technology:
Cached News: