HOME >> MEDICINE >> NEWS
Chemotherapy more effective when given before breast cancer surgery

Giving chemotherapy to women with operable breast cancer before they have surgery not after helps physicians pin down the best treatment regimen and can reduce the extent of surgery, according to a new systematic review.

Preoperative chemotherapy reduced chemo-related infections by 4 percent and the need for mastectomies by 17 percent when compared to postoperative chemotherapy, found reviewers led by Sven Mieog, M.D., of Leiden University Medical Center in the Netherlands.

Mieog and colleagues looked at 14 studies that included 5,500 women with operable breast cancer. Half of the women received preoperative chemotherapy and the rest received chemotherapy after surgery.

The data revealed a higher cancer recurrence rate in women who had chemotherapy before surgery, although this did not affect survival rates, which were similar for both groups.

"Ten studies reported overall survival data on 4,620 women involving 1,139 estimated deaths," the authors write. "There was no detectable difference between preoperative and postoperative chemotherapy."

The review appears in the current issue of The Cochrane Library, a publication of The Cochrane Collaboration, an international organization that evaluates research in all aspects of health care. Systematic reviews draw evidence-based conclusions about medical practice after considering both the content and quality of existing trials on a topic.

One reason for giving chemotherapy first is to shrink tumors before surgery, the researchers say.

Moreover, preoperative chemotherapy allows doctors to see if a tumor is resistant to a particular drug and thus adjust the dose or switch to another drug after surgery. The patient might avoid toxic side effects while getting another chance to receive appropriate systemic treatment, Mieog said.

After surgery, doctors can no longer gauge chemotherapy's effect on tumor size.

"Concerns could be raise
'"/>

Contact: Lisa Esposito
hbns-editor@cfah.org
Center for the Advancement of Health
10-May-2007


Page: 1 2 3

Related medicine news :

1. Chemotherapy with bevacizumab increases risk of blood clots in arteries
2. Chemotherapy may enhance the effectiveness of brain tumor vaccines
3. Chemotherapy temporarily affects the structures of the human brain
4. Chemotherapy gel may fight breast cancer and reduce breast deformity
5. Chemotherapy given directly to the liver improves survival for patients with colorectal cancer
6. Chemotherapy after surgery extends survival for patients with advanced endometrial cancer
7. Chemotherapy errors rare, but have potential for serious consequences
8. Chemotherapy for brain tumors is boosted after vaccine targets resistance-related antigen
9. Chemotherapy options improve for patients with advanced colorectal cancer
10. New treatment effective in counteracting cocaine-induced symptoms
11. Osteoporosis screening and treatment may be cost-effective for selected older men

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/14/2018)... ... December 14, 2018 , ... Our competitor ... has pending lawsuits that claim its talc powder has toxic ingredients that may ... asbestos in its baby powder. The documents also show our competitor's leadership intentionally ...
(Date:12/14/2018)... Calif. (PRWEB) , ... December 14, 2018 , ... Art ... Art of Dentistry, are helping patients in La Mesa, CA interested in cosmetic dentistry ... for individuals whose teeth and gums are not aesthetically appealing because of decay, damage, ...
(Date:12/13/2018)... ... December 13, 2018 , ... Cantata Health, a leading ... outcomes, introduced new enhancements to its NetSolutions™ platform. The new features and partnerships ... technology and screen time. , Enhancements made to EHR and Financial Management ...
(Date:12/13/2018)... ... 13, 2018 , ... New research out of Roswell Park Comprehensive Cancer Center ... significantly more likely to survive than those who are sedentary, adding to the growing ... and treatment strategy. The results were published in a recent issue of the journal ...
(Date:12/13/2018)... Wis. (PRWEB) , ... December 13, 2018 , ... ... as Senior Vice President of Consultant Engagement. Beth brings over 20 years of ... team at Evergreen. Beth is passionate about building strong teams and creating vibrant ...
Breaking Medicine News(10 mins):
(Date:12/13/2018)... , ... December 13, 2018 , ... ... has joined the esteemed Haute Beauty network. , The Haute Beauty Network, ... Dr. Lessner as a leading vision expert and our newest addition to the ...
(Date:12/13/2018)... ... December 13, 2018 , ... The American Board ... to announce a partnership to award Continuing Medical Education (CME/SAM) credits to participants ... has selected ASCP, a leading educational provider for pathologists, as the accredited ACCME ...
(Date:12/13/2018)... ... December 13, 2018 , ... As the ... and established organizations, as well as top talent, have the ability to remain ... them. , Through years of working hand-in-hand with some of the country’s ...
Breaking Medicine Technology:
Cached News: