HOME >> MEDICINE >> NEWS
Chemotherapy more effective when given before breast cancer surgery

Giving chemotherapy to women with operable breast cancer before they have surgery not after helps physicians pin down the best treatment regimen and can reduce the extent of surgery, according to a new systematic review.

Preoperative chemotherapy reduced chemo-related infections by 4 percent and the need for mastectomies by 17 percent when compared to postoperative chemotherapy, found reviewers led by Sven Mieog, M.D., of Leiden University Medical Center in the Netherlands.

Mieog and colleagues looked at 14 studies that included 5,500 women with operable breast cancer. Half of the women received preoperative chemotherapy and the rest received chemotherapy after surgery.

The data revealed a higher cancer recurrence rate in women who had chemotherapy before surgery, although this did not affect survival rates, which were similar for both groups.

"Ten studies reported overall survival data on 4,620 women involving 1,139 estimated deaths," the authors write. "There was no detectable difference between preoperative and postoperative chemotherapy."

The review appears in the current issue of The Cochrane Library, a publication of The Cochrane Collaboration, an international organization that evaluates research in all aspects of health care. Systematic reviews draw evidence-based conclusions about medical practice after considering both the content and quality of existing trials on a topic.

One reason for giving chemotherapy first is to shrink tumors before surgery, the researchers say.

Moreover, preoperative chemotherapy allows doctors to see if a tumor is resistant to a particular drug and thus adjust the dose or switch to another drug after surgery. The patient might avoid toxic side effects while getting another chance to receive appropriate systemic treatment, Mieog said.

After surgery, doctors can no longer gauge chemotherapy's effect on tumor size.

"Concerns could be raise
'"/>

Contact: Lisa Esposito
hbns-editor@cfah.org
Center for the Advancement of Health
10-May-2007


Page: 1 2 3

Related medicine news :

1. Chemotherapy with bevacizumab increases risk of blood clots in arteries
2. Chemotherapy may enhance the effectiveness of brain tumor vaccines
3. Chemotherapy temporarily affects the structures of the human brain
4. Chemotherapy gel may fight breast cancer and reduce breast deformity
5. Chemotherapy given directly to the liver improves survival for patients with colorectal cancer
6. Chemotherapy after surgery extends survival for patients with advanced endometrial cancer
7. Chemotherapy errors rare, but have potential for serious consequences
8. Chemotherapy for brain tumors is boosted after vaccine targets resistance-related antigen
9. Chemotherapy options improve for patients with advanced colorectal cancer
10. New treatment effective in counteracting cocaine-induced symptoms
11. Osteoporosis screening and treatment may be cost-effective for selected older men

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/1/2020)... ... September 01, 2020 , ... Board ... in Glendale. While the office will be the first to bear her name, ... buttock augmentation (Brazilian butt lift), as well as rhinoplasty, facial rejuvenation, and many ...
(Date:9/1/2020)... ... 2020 , ... Dr. Kiran Gill is a Board Certified ... face, breast, and body. In 2018, she founded Aesthetics in Plastic Surgery by ... practice in Southwest Florida. Dr. Gill and her team offer surgical and non-surgical ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... ... recently donated 1,400 N95 face masks to medical first responders across the United ... to make donations of personal protective equipment (PPE) medical centers , ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... ... business support services to dental groups in the United States, today announced the ... community of Beaumont, CA. , Patients will enjoy convenient hours, a comfortable ...
(Date:8/31/2020)... ... 2020 , ... Dr. Chang has over 20 years of ... developmental disabilities, as well as supporting staff in caring for patients and families. ... and staff development. She joined the company in 2015 as Chief of Clinical ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... ... of Cosmetics and Laser Surgery at the University of Rochester Medical Center, in ... at SkinCare Physicians in Boston, with clinical faculty from the Harvard and Yale ...
(Date:8/31/2020)... ... August 31, 2020 , ... Welltech1, the ... that they have invested $400,000 in PopBase, one of two start-ups that beat ... Global Wellness Institute (GWI). , The competition was part of the GWI’s ...
(Date:8/28/2020)... LOS ANGELES (PRWEB) , ... August 28, 2020 , ... ... a board-certified reproductive and endoscopic surgeon and serves as a clinical professor in the ... elected President of the American Laparoscopy Society & Pacific Coast Reproductive Society and is ...
Breaking Medicine Technology:
Cached News: