HOME >> MEDICINE >> NEWS
Chemotherapy options improve for patients with advanced colorectal cancer

For the first time, researchers have shown that a chemotherapy regimen of capecitabine plus oxaliplatin (CAPOX) is as safe and effective as infusional 5-fluorouracil/folinic acid plus oxaliplatin (FUFOX) in the first-line treatment of metastatic colorectal carcinoma (MCRC). The findings are reported today at the 2nd ESMO Scientific & Educational Conference (ESEC) in Budapest, Hungary.

"We conducted this phase III study because the combination of oral capecitabine and oxaliplatin showed promising effects in different phase II studies. The idea of this study was to look whether CAPOX can replace the standard treatment of iv. 5-FU/folinic acid in patients with MCRC", said lead author Dr. Hendrik-Tobias Arkenau, from Clinic Bremen East in Germany.

From 2002 to 2004, the authors randomly assigned 476 patients who had not undergone previous chemotherapy to receive either FUFOX (5-fluorouracil (5-FU) 2000mg/m 24h infusion, folinic acid 500mg/m, oxaliplatin 50mg/m d1,8,15,22; q5 wks) or CAPOX (capecitabine 1000mg/m bid d1-14, oxaliplatin 70mg/m d1 and 8; q3 wks).

So far, based on an analysis of 2541 treatment cycles (1026 FUFOX, 1515 CAPOX), both regimens are comparably toxic and showed similar response rates (ITT-RR: 50% FUFOX and 47% CAPOX, p=NS).

Median length of time without progression of disease was 34.7 weeks in the FUFOX arm and 30.3 weeks in the CAPOX arm, respectively, a difference that was not statistically different (p=0.1), the authors found. Additionally, both treatment arms showed similar overall survival, FUFOX 74.9 weeks and CAPOX 70.9 weeks, p=0.72.

The authors conclude that CAPOX shows comparable efficacy and toxicity profiles compared to the FUFOX regimen in patients chemonaive MCRC.

"This study is important for patients because the CAPOX regimen is more convenient to administer. Patients will appreciate needing to come only twice in three weeks as outpatients to receive the 2 hourly oxaliplatin dose. Esp
'"/>

Contact: Gracemarie Bricalli
gracemarie@esmo.org
41-91-973-1911
European Society for Medical Oncology
6-Jun-2005


Page: 1 2

Related medicine news :

1. Chemotherapy with bevacizumab increases risk of blood clots in arteries
2. Chemotherapy may enhance the effectiveness of brain tumor vaccines
3. Chemotherapy more effective when given before breast cancer surgery
4. Chemotherapy temporarily affects the structures of the human brain
5. Chemotherapy gel may fight breast cancer and reduce breast deformity
6. Chemotherapy given directly to the liver improves survival for patients with colorectal cancer
7. Chemotherapy after surgery extends survival for patients with advanced endometrial cancer
8. Chemotherapy errors rare, but have potential for serious consequences
9. Chemotherapy for brain tumors is boosted after vaccine targets resistance-related antigen
10. Asthma study shows patients have more options to control disease
11. Study sheds light on medication treatment options for bipolar disorder

Post Your Comments:
(Date:11/28/2014)... FL (PRWEB) November 28, 2014 Miami's ... responsive website. Practice founder Dr. Jeffrey Epstein ... Created using a groundbreaking WordPress platform, the site ... , Currently, up to 75% of all ... than ever, these people are logging on with smartphones, ...
(Date:11/28/2014)... Australia (PRWEB) November 28, 2014 ... undergone healthy growth over the past five years. ... increasing acceptance of therapies that are either alternative ... treatments. According to IBISWorld industry analyst David Whytcross, ... ageing population and growing private health insurance membership.” ...
(Date:11/28/2014)... 28, 2014 Written and narrated by award ... Voices releases the “The Happiest Man In the World: ... account of how and why Project C.U.R.E. came to be. ... mother Josie and the Reverend Richard W. Jackson, Dr. Jackson ... of 30, but realized that he wasn’t happy. Prompted by ...
(Date:11/28/2014)... -- Planning on seconds at Thanksgiving Day dinner this year? ... gastroesophageal reflux disease (GERD) -- a few steps may help ... and throat specialist at Lenox Hill Hospital in New York ... Thanksgiving: Pace yourself. Rather than have ... the day. It,s also a good idea to have a ...
(Date:11/28/2014)... only is the Éminence Organic Skin Care team proud ... cancer-causing agents, but they are also proud to support ... help in the fight against breast cancer. This year, ... contribution of $30,000 through participation in the CIBC Run ... Whip Moisturizer and the company’s corporate donation. , On ...
Breaking Medicine News(10 mins):Health News:Top Rhinoplasty Surgeon Launches Innovative Website 2Health News:Alternative Health Therapies in Australia Industry Market Research Report Now Updated by IBISWorld 2Health News:Alternative Health Therapies in Australia Industry Market Research Report Now Updated by IBISWorld 3Health News:Alternative Health Therapies in Australia Industry Market Research Report Now Updated by IBISWorld 4Health News:Thanksgiving Weekend Audiobook Treat! “The Happiest Man In the World: Life Lessons From a Cultural Economist” by Dr. James W. Jackson 2Health News:Don't Let Chronic Heartburn Spoil Your Thanksgiving Feast 2Health News:Éminence Organic Skin Care Donates Record-breaking $30,000 to Breast Cancer Research 2Health News:Éminence Organic Skin Care Donates Record-breaking $30,000 to Breast Cancer Research 3
(Date:11/28/2014)... Nov. 28, 2014  Valeant Pharmaceuticals International, Inc. ... announced that its wholly owned subsidiary, Valeant Pharmaceuticals ... of its outstanding 6.875% Senior Notes due 2018, ... on December 29, 2014 and has mailed an ... the redemption, approximately US$500 million aggregate principal amount ...
(Date:11/28/2014)... 2014 /CNW Telbec/ - Ergoresearch Ltd « Ergoresearch » (TSXV: ... Dominique Boudreau who will hold the position ... Dominique Boudreau was acting as corporate controler of ... for more than seven years for Laboratoire Langelier, a ... Mrs. Boudreau replaces Mr. Greco who was previously appointed ...
(Date:11/28/2014)... Kan. , Nov. 28, 2014 Aratana ... company focused on the licensing or acquisition, development and ... other companion animals, today announced that it will present ... Conference, to be held December 2-3, 2014, at the ... . Steven St. Peter , ...
Breaking Medicine Technology:Valeant Announces Redemption of US$445.0 Million Aggregate Principal Amount of its Outstanding 6.875% Senior Notes due 2018 2Ergoresearch announces the appointment of its new Vice Président Finance 2Ergoresearch announces the appointment of its new Vice Président Finance 3Aratana Therapeutics to Present at the 26th Annual Piper Jaffray Healthcare Conference 2
Cached News: