HOME >> MEDICINE >> NEWS
Chemotherapy options improve for patients with advanced colorectal cancer

For the first time, researchers have shown that a chemotherapy regimen of capecitabine plus oxaliplatin (CAPOX) is as safe and effective as infusional 5-fluorouracil/folinic acid plus oxaliplatin (FUFOX) in the first-line treatment of metastatic colorectal carcinoma (MCRC). The findings are reported today at the 2nd ESMO Scientific & Educational Conference (ESEC) in Budapest, Hungary.

"We conducted this phase III study because the combination of oral capecitabine and oxaliplatin showed promising effects in different phase II studies. The idea of this study was to look whether CAPOX can replace the standard treatment of iv. 5-FU/folinic acid in patients with MCRC", said lead author Dr. Hendrik-Tobias Arkenau, from Clinic Bremen East in Germany.

From 2002 to 2004, the authors randomly assigned 476 patients who had not undergone previous chemotherapy to receive either FUFOX (5-fluorouracil (5-FU) 2000mg/m 24h infusion, folinic acid 500mg/m, oxaliplatin 50mg/m d1,8,15,22; q5 wks) or CAPOX (capecitabine 1000mg/m bid d1-14, oxaliplatin 70mg/m d1 and 8; q3 wks).

So far, based on an analysis of 2541 treatment cycles (1026 FUFOX, 1515 CAPOX), both regimens are comparably toxic and showed similar response rates (ITT-RR: 50% FUFOX and 47% CAPOX, p=NS).

Median length of time without progression of disease was 34.7 weeks in the FUFOX arm and 30.3 weeks in the CAPOX arm, respectively, a difference that was not statistically different (p=0.1), the authors found. Additionally, both treatment arms showed similar overall survival, FUFOX 74.9 weeks and CAPOX 70.9 weeks, p=0.72.

The authors conclude that CAPOX shows comparable efficacy and toxicity profiles compared to the FUFOX regimen in patients chemonaive MCRC.

"This study is important for patients because the CAPOX regimen is more convenient to administer. Patients will appreciate needing to come only twice in three weeks as outpatients to receive the 2 hourly oxaliplatin dose. Esp
'"/>

Contact: Gracemarie Bricalli
gracemarie@esmo.org
41-91-973-1911
European Society for Medical Oncology
6-Jun-2005


Page: 1 2

Related medicine news :

1. Chemotherapy with bevacizumab increases risk of blood clots in arteries
2. Chemotherapy may enhance the effectiveness of brain tumor vaccines
3. Chemotherapy more effective when given before breast cancer surgery
4. Chemotherapy temporarily affects the structures of the human brain
5. Chemotherapy gel may fight breast cancer and reduce breast deformity
6. Chemotherapy given directly to the liver improves survival for patients with colorectal cancer
7. Chemotherapy after surgery extends survival for patients with advanced endometrial cancer
8. Chemotherapy errors rare, but have potential for serious consequences
9. Chemotherapy for brain tumors is boosted after vaccine targets resistance-related antigen
10. Asthma study shows patients have more options to control disease
11. Study sheds light on medication treatment options for bipolar disorder

Post Your Comments:
(Date:2/27/2015)... Ticket Down announces that Ed Sheeran ... months of 2015. Tickets for his tour have been ... a record pace. , Ed Sheeran 2015 Tour ... Center, Wednesday, May 6, 2015 , 5/7/15, Ed Sheeran Tickets, ... 7, 2015 , 5/9/15, Ed Sheeran Tickets, Tulsa, OK BOK ...
(Date:2/27/2015)... Local lice removal service reports that cases ... areas of Pinecrest, Key Biscayne, Coral Gables, Miami Beach and ... attempt to isolate and eradicate the problem. , Among ... may be partly to blame. As kids put their heads ... contact that can allow for the spread of head lice. ...
(Date:2/27/2015)... 2015 The producers of Forbes Living ... Stop Soldier Suicide will be featured in an upcoming ... and join the fight to save those who fight to ... of the toughest a U.S. service member has ever had ... Veterans come home to lost jobs, strained relationships, financial woes, ...
(Date:2/27/2015)... (PRWEB) February 27, 2015 With Spring’s wet ... keep the condition of their crawl spaces in mind. The ... of the most common FAQs regarding crawl space conditions and ... an answer to owners that are confused as to how ... that, “One of the most common ways is through cracks ...
(Date:2/27/2015)... February 27, 2015 Leading massage chair ... wellness to Americans nationwide. Each month they take a look ... and wellness, and healthy living. In the month of March ... Sleep Awareness Week starts by bringing awareness to the ... year Sleep Awareness Week will start on March 2nd, and ...
Breaking Medicine News(10 mins):Health News:Ed Sheeran Tickets at the Hollywood Bowl, Verizon Theatre, The Mann Center, Darlings Waterfront Pavilion, Moda Center, BOK Center, Consol Energy & Red Rocks Now On Sale 2Health News:Ed Sheeran Tickets at the Hollywood Bowl, Verizon Theatre, The Mann Center, Darlings Waterfront Pavilion, Moda Center, BOK Center, Consol Energy & Red Rocks Now On Sale 3Health News:Ed Sheeran Tickets at the Hollywood Bowl, Verizon Theatre, The Mann Center, Darlings Waterfront Pavilion, Moda Center, BOK Center, Consol Energy & Red Rocks Now On Sale 4Health News:Parents frustrated as selfies continue to contribute to the spread of head lice in Miami according to the largest Lice Removal Service in Miami called Lice Troopers 2Health News:Forbes Living Joins Fight against Soldier Suicide with New PSA 2Health News:Forbes Living Joins Fight against Soldier Suicide with New PSA 3Health News:Forbes Living Joins Fight against Soldier Suicide with New PSA 4Health News:Crawl Space FAQs are Answered in Clean Crawls Latest Article 2Health News:Emassagechair Wants Shoppers to Think About the Benefits of Massage During National Sleep Awareness Week 2Health News:Emassagechair Wants Shoppers to Think About the Benefits of Massage During National Sleep Awareness Week 3
(Date:2/26/2015)... , Feb. 26, 2015  Mail-service and specialty ... consumers, employers and government health plans $23.3 billion ... by the Pharmaceutical Care Management Association (PCMA). ... offers one of the easiest ways to reduce ... Mark Merritt . "Policymakers should resist efforts to ...
(Date:2/26/2015)... N.Y. , Feb. 26, 2015 Every ... more research to fight heart disease.  Nevertheless, year after ... on ElectroCardioGrams (EKG) as the first test to determine ... they have chest pain or not, even though that ... occurs despite the fact that doctors know, (while most ...
(Date:2/26/2015)... , Feb. 26, 2015 Research and Markets ... the "Radiation Therapy Equipment - Global Strategic Business ... This report analyzes the worldwide markets for Radiation Therapy ... Linear Accelerator, Treatment Planning Systems, and Radiation Therapy Simulator. ... Canada , Japan ...
Breaking Medicine Technology:PCMA: Report Shows High-Tech Specialty and Mail-Service Pharmacies Will Reduce Costs for Texas Employers, Consumers and Public Programs by $23.3 Billion 2National Heart Health Month In February 2Radiation Therapy Equipment - Global Strategic Business Report 2015-2020: Linear Accelerator, Treatment Planning Systems, and Radiation Therapy Simulator 2
Cached News: