HOME >> MEDICINE >> NEWS
Children's Hospital Oakland Research Institute -- cancer study

November 17, 2006 - Oakland, CA A new study conducted by scientists at Children's Hospital Oakland Research Institute (CHORI) identifies a specific enzyme that can cause the death of cancer cells. Researchers studied the behavior of an enzyme called sphingosine phosphate lyase (SPL), which can regulate cell growth and death by lowering the levels of a natural, growth-promoting lipid called sphingosine-1-phosphate, or S1P.

The study, led by Julie Saba, M.D., Ph.D. is the first to link the SPL enzyme to cancer, and it appears in the November issue of the Proceedings of the National Academy of Sciences. Researchers identified SPL as a key regulator of cancer cells. They discovered that if the cancer cells were stressed by chemotherapy, SPL could be activated or "turned on" to reduce the levels of S1P, which is needed to cause cell death. "The enzyme SPL senses when a cell has sustained damage or is undergoing mutations," said Dr. Saba. "Once the enzyme is aware of these changes it responds by killing the cell. We hope to find new ways to leverage the body's own natural responses to these mutated or damaged cells to target cancer cells."

Among pediatric diseases, cancer is the leading cause of death in the United States. Approximately 9,500 new cases of cancer are expected to occur in children between infancy and 15 years of age by the end 2006.* "Although we're beginning our studies in colon cancer, we believe our research findings will have a direct impact on investigations for other cancers, including pediatric cancers," said Dr. Saba. "It is premature to suggest that SPL is the answer to curing cancer, but our research findings should dramatically advance our search for a cure," said Dr. Saba.

Dr. Saba and her team conducted their year-long research by studying a number of different human cell lines as well as human colon cancer tissues and mouse intestinal polyps. They wanted to see what happens when you increase or decrease the
'"/>

Contact: Diana Yee
dyee@mail.cho.org
510-428-3120
Children's Hospital & Research Center at Oakland
20-Nov-2006


Page: 1 2

Related medicine news :

1. Support for Childrens Health and Medicare Protection Act given to House leaders by ACP
2. Childrens brain responses predict impact of sleep loss on attention
3. Childrens Hospital and Pitt lead national trial of hypothermia to treat pediatric brain injury
4. Childrens Hospital Boston presents at the American College of Cardiology Scientific Sessions
5. Childrens packed lunches: Are they even worse than Turkey Twizzlers?
6. Childrens Hospital Boston neurosurgeons to perform brain tumor removal during live Web cast
7. Study by Childrens Hospital and Carnegie Mellon explains crucial deficit in children with autism
8. Ear infection expert from Childrens Hospital of Pittsburgh leads interactive demo on diagnosis
9. Cincinnati Childrens researchers publish findings on potential target for leukemia treatment
10. Childrens Hospital of Pittsburgh and UPMC surgeons save two lives with domino transplant
11. Johns Hopkins Childrens Center to lead largest-ever study on kidney disease in children

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/1/2020)... ... September 01, 2020 , ... Feeding Matters , ... children with Pediatric Feeding Disorder (PFD), is pleased to announce that the U.S. Centers ... diagnostic code (R code) in the next edition of the U.S. International Classification ...
(Date:8/31/2020)... ... August 31, 2020 , ... ... exclusively to funding innovative lymphoma research and serving the lymphoma community through a ... the 10th Anniversary of Blood Cancer Awareness Month (BCAM) and its international ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... ... cloud-based business management solution for chiropractors, announced today the launch of its integrated, ... professionals can start running their virtual practice in under 90 seconds. , ...
(Date:8/31/2020)... ... ... for Covid-19 “PTS” with Mediation & Hypnosis , At this very turbulent time in ... deep anxiety, immense stress, and right now are needing serious relief from a constant state ... planet are experiencing a great degree of emotional discomfort, be it fear or worrying about ...
(Date:8/29/2020)... (PRWEB) , ... August 29, 2020 , ... When professor ... perhaps with greater ease than most people would. Rather than become melancholic, however, he ... deep advice on achieving one’s dreams. Randy Pausch took a negative situation and turned ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... ... 01, 2020 , ... September is National Ovarian Cancer Awareness Month. Ovarian ... other cancer of the female reproductive system. The American Cancer Society estimates that ... women will die from this disease. Throughout the month of September, Women’s Excellence ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... ... research and advisory guide, has named Cloudticity a Gold winner in the 15th ... industry and peer recogniti o ns from Network Products Guide honoring ...
(Date:8/27/2020)... Pa. (PRWEB) , ... August 27, 2020 , ... ... care coordination software, today announced the successful completion of their 2020 System and ... well as their HITRUST® interim assessment and MARS-E compliance assessment. These achievements reflect ...
Breaking Medicine Technology:
Cached News: