HOME >> MEDICINE >> NEWS
Children's Hospital Oakland new sickle cell research

July 6, 2005-Oakland, CA-- A new study led by a researcher at Children's Hospital & Research Center at Oakland is the first to find that an amino acid deficiency in sickle cell disease is the result of hemolysis, a process where red blood cells rupture and release their contents into the blood stream. Low availability of the amino acid arginine is associated with lung disease and death in adult sickle cell patients.

The study, published in the July 6th issue of the Journal of American Medical Association (JAMA) supports new therapeutic strategies aimed at increasing arginine levels either through nutritional supplements or by developing new drug therapies that disable the arginase enzyme that consumes arginine.

"Lower amino acid ratios, which indicates low arginine availability, were found in patients who had more severe pulmonary hypertension, a condition involving high blood pressure in arteries carrying blood from the heart to small vessels in the lungs," said Claudia Morris, M.D., an Emergency Department physician and researcher at Children's Hospital Oakland. "This incurable condition is the leading cause of death in adults with sickle cell disease," she added.

The published report in JAMA also highlights important new warning signs that may predict the severity of the disease and could be useful in identifying adult patients at risk for early death through a simple blood test that measures amino acid levels. The study is the result of a multi-center collaboration that includes Dr. Morris as lead investigator, Mark Gladwin, M.D. and Greg Kato M.D. from the National Heart, Lung, and Blood Institute, which is a part of the National Institutes of Health and Sidney Morris Jr., Ph.D from the University of Pittsburgh School of Medicine.

"With this new finding and continued research, we hope to increase our understanding of the development of pulmonary hypertension not only in sickle cell disease, but in thalassemia (Cooleys anemi
'"/>

Contact: Diana Yee
dyee@mail.cho.org
510-428-3120
Children's Hospital & Research Center at Oakland
5-Jul-2005


Page: 1 2

Related medicine news :

1. Support for Childrens Health and Medicare Protection Act given to House leaders by ACP
2. Childrens brain responses predict impact of sleep loss on attention
3. Childrens Hospital and Pitt lead national trial of hypothermia to treat pediatric brain injury
4. Childrens Hospital Boston presents at the American College of Cardiology Scientific Sessions
5. Childrens packed lunches: Are they even worse than Turkey Twizzlers?
6. Childrens Hospital Oakland Research Institute -- cancer study
7. Childrens Hospital Boston neurosurgeons to perform brain tumor removal during live Web cast
8. Study by Childrens Hospital and Carnegie Mellon explains crucial deficit in children with autism
9. Ear infection expert from Childrens Hospital of Pittsburgh leads interactive demo on diagnosis
10. Cincinnati Childrens researchers publish findings on potential target for leukemia treatment
11. Childrens Hospital of Pittsburgh and UPMC surgeons save two lives with domino transplant

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2018)... ... 31, 2018 , ... Becker's Healthcare is pleased to release ... community hospitals as well as facilities affiliated with large health systems. Some hospitals ... cities. The hospitals continue to grow in many communities, opening new departments and ...
(Date:8/31/2018)... ... August 31, 2018 , ... Kessler Foundation, a major ... an MRI Simulator. In the MRI Simulator, the individual experiences the conditions of ... mock scan experience, research participants become accustomed to the sights and sounds of ...
(Date:8/31/2018)... Pa. (PRWEB) , ... August 31, 2018 , ... ... those offered by the American Heart Association (AHA) to be responsive for procurement ... concerns and purchasing managers may now reap the benefits. Companies like Pacific Medical ...
(Date:8/31/2018)... ... August 31, 2018 , ... ... on the impact of a biofield energy treated nutraceutical to improve overall immunity ... for immune function and blood, as well as, inflammation. The following data was ...
(Date:8/31/2018)... (PRWEB) , ... August 31, 2018 , ... Saturday, September ... as part of the Iowa State Cyclones season opener game. At 7pm, the Cyclones ... as the National Anthem starts to play, Team Fastrax™ will jump in with their ...
Breaking Medicine News(10 mins):
(Date:9/15/2018)... ... 2018 , ... Harris Teeter announced today it will launch ... , Throughout the month of September, the company invites their generous shoppers and ... transaction to the nearest dollar to help support the American Red Cross in ...
(Date:9/13/2018)... ... September 13, 2018 , ... AccentCare, Inc., a nationwide ... making its regional Texas Home Health operations the largest Texas-based post-acute care ... and personal care services. , Texas Home Health operations serve all 254 counties ...
(Date:9/12/2018)... ... ... Lifetime Wellness , a leading provider of person-centered wellness, life enrichment, ... store to offer exclusive aromatherapy products to a wider community. to bring enhanced ... store to offer our custom aromatherapy to not only our residents, but a broader ...
Breaking Medicine Technology:
Cached News: