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tient can be transplanted into another individual without passing on the disease. MSUD is one such disease," Dr. Mazariegos said. "Because Children's and UPMC are the leading transplant centers in the world for patients with MSUD, we foresee the opportunity to continue performing domino transplants in appropriate situations. We have performed more than 20 liver transplants in patients with MSUD, and in each and every patient, liver function has returned to normal, metabolically curing these patients. Domino transplants are an extremely resourceful approach to overcome the scarcity of organs available for transplant."

Only 109 domino transplants have been performed in the United States, all involving heart or liver transplants, according to the United Network for Organ Sharing.

"Our novel immunosuppression therapies have enabled our live donor liver transplant recipients to recover more quickly without dependency on heavy anti-rejection medications," commented Amadeo Marcos, M.D., professor of surgery, chief, division of transplantation and clinical director of the Starzl Transplantation Institute. "Furthermore, through our exceptional partnership with surgeons at Children's Hospital, we have been able to expand the donor pool to adult recipients who can benefit by receiving an MSUD liver, since the disease is not transferred to the recipient.

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Contact: Marc Lukasiak
marc.lukasiak@chp.edu
412-692-5016
Children's Hospital of Pittsburgh
2-Oct-2006

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