HOME >> MEDICINE >> NEWS
Cincinnati Children's researchers publish findings on potential target for leukemia treatment

Cincinnati Children's Hospital Medical Center today announced the publication of pioneering research identifying the crucial role and novel mechanism of action of the protein RhoH GTPase in the development and activation of cells critical to the immune system. The findings, along with other studies, suggest that RhoH GTPase may provide a target for therapeutic intervention in some types of leukemia. The paper is due to appear in an upcoming edition of the journal Nature Immunology and was recently posted in the advance online publication section of the journal's website, (www.nature.com/ni/index.html).

The paper describes detailed genetic and biochemical studies undertaken by researchers in the Division of Experimental Hematology and the Division of Immunobiology. The investigators succeeded in identifying a crucial role for RhoH GTPase in the development of thymocytes and activation of T-lymphocytes, both key processes in immune cell development. In addition, the researchers uncovered a novel mechanism for regulating RhoH activity, which may have broad implications in improving researchers' understanding of the mechanism of action of the Rho GTPase protein family and provide a potential target for leukemia drug development.

"We continue to make important progress in deciphering the molecular processes involved in the development and maintenance of the immune and blood system and how disruption of key proteins may contribute to leukemia," said David A Williams, M.D., Director of Experimental Hematology, Cincinnati Children's. "Through a collaboration with Ohio State University Comprehensive Cancer Center, we are now focused on translating these findings into developing new ways to target the protein as a novel approach to treating hematological malignancy."

The development of mature white blood cells, including lymphocytes, is a highly complex process involving cell growth as wel
'"/>

Contact: Jim Feuer
jim.feuer@cchmc.org
513-636-4656
Cincinnati Children's Hospital Medical Center
9-Oct-2006


Page: 1 2

Related medicine news :

1. Cincinnati surgeons pediatric laparoscopic liver surgery a world first
2. Verbal medical order errors reduced to zero, according to new Cincinnati Childrens study
3. Cincinnati surgeons report new treatment for often-fatal injury
4. Cincinnati Childrens applauds EU approval of rotavirus vaccine
5. Cincinnati Childrens scientist wins achievement award for advances in heart disease research
6. Univ. of Cincinnati receives $17.4 million grant to lead stroke study
7. Support for Childrens Health and Medicare Protection Act given to House leaders by ACP
8. Childrens brain responses predict impact of sleep loss on attention
9. Childrens Hospital and Pitt lead national trial of hypothermia to treat pediatric brain injury
10. Childrens Hospital Boston presents at the American College of Cardiology Scientific Sessions
11. Childrens packed lunches: Are they even worse than Turkey Twizzlers?

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/21/2020)... (PRWEB) , ... February 21, 2020 , ... Dr. Stong, ... strong advocate for giving back. He has been a long-time volunteer with Healing ... goal of this particular HTC trip is to provide cleft lip and palate procedures ...
(Date:2/21/2020)... ... 21, 2020 , ... The American Society for Clinical Pathology ... Boston, MA, in October 2021. The prestigious, invitation-only event—organized by the Union for ... of health, city and industry leaders, senior executives and other influential players ...
(Date:2/20/2020)... (PRWEB) , ... February 20, 2020 , ... ... agents, has a new release with next generation API integration functionality which ... by VisitorsCoverage Inc. in 2017, TMQuotes was the first white label ...
(Date:2/19/2020)... ... 2020 , ... MedTech IGNITE Expands Steering Committee, Faculty and ... 2020 Cohort , The Massachusetts Medical Device Industry Council ( MassMEDIC ) announced ... startup founders and CEOs to participate in the 2020 IGNITE Cohort. , ...
(Date:2/19/2020)... ALPHARETTA, Ga. (PRWEB) , ... February 19, 2020 ... ... to announce they are holding a CoolEvent for FDA-cleared CoolSculpting®, the world’s most ... at 6345 Halcyon Way, Suite 850 in the Halcyon Village Center in Alpharetta, ...
Breaking Medicine News(10 mins):
(Date:2/19/2020)... ... February 19, 2020 , ... Aspire Regenerative, a leader in offering therapies ... Pharmacy for a free weight-loss event on March 1, 2020. It will take place ... Jolla, CA, 92037. , During the event, physicians and pharmacists will lead an informative ...
(Date:2/19/2020)... ... February 19, 2020 , ... Drs. Mario Canal and Ben Calem ... 2020 at The Mansion in Voorhees. The course features guest speaker, Dr. Amanda Seay, ... Dental implants, including All-on-4® full mouth dental implants, are a major ...
(Date:2/19/2020)... ... February 19, 2020 , ... The Team Type 1 ... to medicine for everyone affected by diabetes, announced a partnership with VeloCity, a fundraising ... The third annual VeloCity event takes place on May 2nd and begins on the ...
Breaking Medicine Technology:
Cached News: