Cincinnati Children's scientist wins achievement award for advances in heart diseas...( CINCINNATI Jeffrey Robbins Ph.D. a m...),Health

CINCINNATI Jeffrey Robbins, Ph.D., a molecular cardiovascular biologist at Cincinnati Children's Hospital Medical Center, will be honored with one of the most prestigious awards given by the American Heart Association, the 2005 Research Achievement Award, which is presented annually for achievements in cardiovascular research.

Dr. Robbins is a specialist in molecular cardiology, a branch of medical research that focuses on understanding the cellular functions of the heart, including the identification of genes associated with heart disease.

"This award is being presented to Dr. Robbins for his seminal contributions to the field of cardiovascular biology that have profoundly changed the pace and direction of cardiac research. His discoveries placed a new set of genetic tools in the hands of investigators around the world, thus stimulating a dramatically accelerated worldwide effort to identify and subsequently modify inborn molecular flaws at work in heart and blood vessel diseases," according to a written statement by the AHA.

Dr. Robbins studies the cause-and-effect relationships between mutations in proteins and their connection to heart disease. To understand these relationships, and to establish models in which disease processes can be studied over a long period of time, Dr. Robbins and colleagues have created genetically modified laboratory models with human cardiovascular disorders. He and his team of researchers have identified specific protein mutations and alterations in protein levels that underlie basic disease processes. With this information, scientists can determine whether the protein directly or indirectly causes changes in the heart. By purposely creating the expression of an engineered protein in the heart, scientists can study the consequences of a single genetic manipulation at the molecular, biochemical, cytological and physiologic levels.

"In a remarkable series of experiments, Dr. Robbins has made monumental
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Contact: Amy Reyes
amy.reyes@cchmc.org
513-636-9684
Cincinnati Children's Hospital Medical Center
11-Nov-2005

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