HOME >> MEDICINE >> NEWS
Clarifying controversy in multiple sclerosis

Multiple sclerosis (MS) is a crippling autoimmune disease of the central nervous system (CNS) in which the protective nerve cell coating called myelin is damaged. Although uncontrolled CNS inflammation by immune cells called microglia (MG) and production of the protein TNF-alpha are considered important causes of demyelination and loss of nerve (neuron) function in MS, there is evidence to suggest that a controlled inflammatory response may actually restore damaged myelin and nerve function. Now, in a study appearing online on March 23 in advance of print publication in the April issue of the Journal of Clinical Investigation, researcher Michal Schwartz and colleagues at the Weizmann Institute of Science in Israel help clarify the controversy by reporting that it is the mechanism by which the MGs are activated that determines whether they are destructive or protective. Using both mouse and rat animal models of MS, the authors show that production by immune cells known as helper T cells of small amounts of a proinflammatory protein called IFN-gamma or production of an anti-inflammatory protein IL-4 could stimulate MGs to support nerve cell survival. In contrast, the researchers show that MGs fail to protect neurons when they are exposed to high doses of IFN-gamma, because high levels of IFN-gamma stimulate the MGs to produce TNF-alpha. The results demonstrate that the helper T cells can have direct control over MG action, stimulating them to either support or destroy nerve cell function through production of IL-4, and suggest that stimulation of MGs with IL-4 may help in MS clinical recovery.


'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
23-Mar-2006


Page: 1

Related medicine news :

1. Drug-eluting stent controversy explored in the American Heart Hospital Journal
2. IOM report should end nevirapine controversy, HIVMA says
3. DNA vaccine against multiple sclerosis appears safe, potentially beneficial
4. University hospitals wins multiple national IT awards for electronic patient data bank
5. Revlimid data presented at ASCO stands to change the way physicians treat multiple myeloma
6. Glucosamine-like supplement inhibits multiple sclerosis, type 1 diabetes
7. Testosterone may help men with multiple sclerosis
8. Mayo Clinic Cancer Center researcher finds mold by-product kills multiple myeloma
9. Mayo Clinic Cancer Center -- individualizing treatment for multiple myeloma patients
10. New GreeneChip identifies multiple pathogens rapidly and accurately
11. GreeneChip -- New diagnostic tool that rapidly and accurately identifies multiple pathogens

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Clarifying controversy multiple sclerosis

(Date:4/28/2015)... April 28, 2015 Aultman Hospital ... Advantage (WCA) to transition its outpatient wound center ... hospital’s commitment to the specialty of wound care ... the country currently working with Wound Care ... advanced wound care treatments and hyperbaric oxygen therapy ...
(Date:4/28/2015)... (PRWEB) April 28, 2015 Consolidated ... are moving forward nationwide, as courts overseeing proceedings ... next month. According to court documents issued in ... the next status conference in the federal Xarelto ... 9:00 a.m. C.S.T. (In Re: Xarelto Products ...
(Date:4/28/2015)... Orange, N.J. (PRWEB) April 28, 2015 Seton ... of Kathleen M. Boozang as the new Dean of Seton ... Dean effective July 1, 2015. , Boozang, currently Associate ... Hall Law in 1990. She helped launch and currently ... Law & Policy, ranked a Top 10 law health ...
(Date:4/28/2015)... April 28, 2015 April 8th, ... Debbie Durkin’s “RockNRolla Movie Awards” EcoLuxe Lounge, with ... event. Durkin Entertainment, Los Angeles’ leading producer of ... the organizing force behind this event, which featured ... and socially conscious products and services. The EcoLuxe ...
(Date:4/28/2015)... April 28, 2015 Children’s Medical ... the cause of medical foods and formulas through ... as the organization’s new executive director. , Thousands ... health consequences because of conditions and diseases that ... diet. To live and thrive, they are ...
Breaking Medicine News(10 mins):Health News:Aultman Hospital Transitions Electronic Medical Record for Wound Center with Wound Care Advantage 2Health News:Aultman Hospital Transitions Electronic Medical Record for Wound Center with Wound Care Advantage 3Health News:Xarelto Lawsuits Move Forward Nationwide, with Scheduling of May Conferences in Federal, State Litigations 2Health News:Xarelto Lawsuits Move Forward Nationwide, with Scheduling of May Conferences in Federal, State Litigations 3Health News:Seton Hall University Announces Kathleen M. Boozang as New Dean for Law School 2Health News:Seton Hall University Announces Kathleen M. Boozang as New Dean for Law School 3Health News:Choices Recovery South Bend Examines Support Systems in Treatment with Hollywood's Mike Pericoloso 2Health News:Children's Medical Nutrition Alliance (CMNuA) Hires Kaycee Childress as Executive Director 2
(Date:4/28/2015)... , April 28, 2015 Konica ... achieved record sales growth for fiscal year ended ... digital radiography family of Primary Imaging Solutions.  The ... fueled company growth to double digit sales figures ... solutions includes the AeroDR XE, a wireless flat ...
(Date:4/28/2015)... 28, 2015  nUro, Inc. (the "Company") announced ... invest in Rosellini Scientific Benelux, SPRL. This marks the ... equity injections and one acquisition). nUro, Inc. plans to ... rapid prototyping labs in Wallonia and in conjunction ... investment comes in conjunction with notice of an ...
(Date:4/28/2015)... BIRMINGHAM, Ala. , April 28, 2015 /PRNewswire/ ... solution company for quickly and accurately capturing complete ... introduces the rebranding of its software platform to ... learns and simplifies what surgeons need to successfully ... unreasonable and unacceptable burden on surgeons to micro-dictate ...
Breaking Medicine Technology:Konica Minolta Sets Record Digital Radiography Sales 2nUro, Inc. Invests in Wallonia-Based Medtech Company 2nUro, Inc. Invests in Wallonia-Based Medtech Company 3nUro, Inc. Invests in Wallonia-Based Medtech Company 4Vincari introduces Lightspeed Valet, a web and mobile software solution for delivering ICD-10 surgical documentation at the point-of-care with extreme speed and accuracy 2
Cached News: