Clevidipine during heart surgery improves blood pressu...( th clevidipine experienced significantl...),Health

th clevidipine experienced significantly improved blood pressure control over those who received nitroglycerin (6.02 vs. 14.88 AUC) or nitroprusside (8.94 vs. 17.28 AUC) (p < 0.05 for both studies). The third study found no significant difference in blood pressure control between clevidipine and nicardipine (5.27 vs. 5.67 AUC). The safety outcomes were similar for all medications. In a separate but supporting study, the same research team found that a higher AUC in cardiac surgery patients is a significant indicator of increased 30-day mortality.

"More research is needed to confirm the benefits of clevidipine, but these initial results against three very commonly used therapies demonstrate a new potentially valuable alternative, which is very encouraging," said Solomon Aronson, M.D., of Duke University Medical Center and lead author of the study. "With a better understanding of how to effectively control blood pressure during cardiac surgery, we believe we can significantly improve the outcomes of those operations, all while ensuring patient safety."

Dr. Aronson will present this study Tuesday, March 27 at 12:00 p.m. in Hall A.

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Plasma Pro-B-Type Natriuretic Peptide in Discriminating Between Cardiac and Pulmonary Dyspnea in the Population (Presentation Number: 415-4)

Natriuretic peptides are demonstrating utility in helping emergency room doctors distinguish between lung-related or heart-related dyspnea, or shortness of breath. These peptides are natural antagonists to renin, an enzyme produced in the kidneys that leads to high blood pressure. Shortness of breath from heart complications is much different from shortness of breath caused by pulmonary complications, carrying separate risks and requiring different treatment regimens. Researchers in Denmark sought to determine the usefulness of measuring pro-B-type natriuretic peptide levels in screening the general public for an accurate diagnosis of dyspne
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Contact: Leslie Humbel
lhumbel@spectrumscience.com
504-613-2418
American College of Cardiology
27-Mar-2007

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