HOME >> MEDICINE >> NEWS
Clinical factors can help determine risk of prostate cancer death after radical prostatectomy

Clinical factors including the time to biochemical recurrence following surgery can help predict the risk of prostate cancer death for patients following a radical prostatectomy, according to a study in the July 27 issue of JAMA.

Radical prostatectomy (removal of the prostate) is one of the most common treatments for prostate cancer and generally provides excellent cancer control, according to background information in the article. However, approximately 35 percent of patients will develop a prostate-specific antigen (PSA) recurrence ("biochemical recurrence") within 10 years after surgery. Due to the sensitivity of PSA to detect disease recurrence early, many patients have a long interval between biochemical recurrence and the development of local recurrence or distant metastasis.

Given the protracted natural history, the researchers had previously identified clinical variables to help stratify patients for risk of metastasis: time from surgery to biochemical recurrence, pathological Gleason score (a grading system for prostate tumors), and PSA doubling time (PSADT; the time it takes for the PSA value to double). Previous research has confirmed that a short PDADT is a risk factor for clinical progression and prostate cancer-specific death.

Stephen J. Freedland, M.D., of The Brady Urological Institute, Johns Hopkins Medicine, Baltimore, and colleagues conducted a study to 1) identify clinical factors that are associated with increased risk for prostate cancer-specific death following radical prostatectomy, and 2) to identify men who are at high risk and may benefit from aggressive treatment and as well as to identify those men who are at low risk and can be safely observed. The study included 379 men who had undergone radical prostatectomy between 1982 and 2000 and who had a biochemical recurrence. The average follow-up after surgery was 10.3 years.

The researchers found that PSA doubling time (less than 3.0 vs. 3.0-8.9 vs
'"/>

Contact: Trent Stockton
410-955-8665
JAMA and Archives Journals
26-Jul-2005


Page: 1 2

Related medicine news :

1. Clinical data suggest potential versatility of ALIMTA-based regimens in lung cancer
2. Susan G. Komen for the Cure and American Society of Clinical Oncology partner in national initiative
3. Clinical review -- A psychological approach to the management of irritable bowel syndrome
4. NHLBI Asthma Clinical Research Networks and ALA ACRC Network to present at ATS 2007
5. Clinical trial data for Perforomist Inhalation Solution presented at International ATS Conference
6. Clinical guidelines for blood conservation during cardiac procedures developed
7. Clinical trial data for Perforomist Inhalation Solution to be presented at ATS on May 20, 2007
8. Clinical trial coordinators need more financial conflict-of-interest training
9. Clinical studies evaluate potential treatments for mouth ulcers
10. NIH names Clinical Trial Units for the Microbicide Trials Network
11. Clinical Trials Units selected for newly restructured HIV/AIDS research networks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... ... August 31, 2020 , ... ... improve outcomes for patients with advanced heart failure, today announced that the company ... the amount of $555,358 from the National Heart, Lung, and Blood Institute of ...
(Date:8/28/2020)... ... August 28, 2020 , ... Ernst & ... was named an Entrepreneur Of The Year® 2020 Florida Award finalist. Now in ... whose ambitions deliver innovation, growth and prosperity as they build and sustain successful ...
(Date:8/28/2020)... ... August 28, 2020 , ... The 15 ... customized Lighthouse Health & Wellness mobile app and web-portal. NCPCV received a 2020 ... Foundation awards grants each year to organizations, such as Destination Imagination, which support ...
(Date:8/28/2020)... ... ... Integrated Viral Protection (IVP Air) today announced that the True North ... Biodefense Indoor Air Protection System that is the first system designed and proven to ... with the filtration system on September 8th. , The IVP Air S1 model ...
(Date:8/28/2020)... ... August 28, 2020 , ... A July 27 article ... are at an increased risk of developing severe COVID-19 symptoms. The article does ... because the same organ systems that the coronavirus attacks are already suffering from ...
Breaking Medicine News(10 mins):
(Date:9/3/2020)... ... September 03, 2020 , ... ... can safely return to schools and classrooms across the United States, IntraLogic ... its technology product line. TEMPE is a non-contact, wall-mounted scanning thermometer that rapidly ...
(Date:9/1/2020)... ... September 01, 2020 , ... Mara C. Weinstein Velez, M.D., ... the University of Rochester Medical Center, in Upstate New York. She completed a ... clinical faculty from the Harvard and Yale Departments of Dermatology and is one ...
(Date:8/31/2020)... AVIV, Israel (PRWEB) , ... August 31, 2020 ... ... to specialize in wellness-related technologies, today announced that they have invested $400,000 in ... competition that ran in collaboration with the Global Wellness Institute (GWI). , ...
Breaking Medicine Technology:
Cached News: