HOME >> MEDICINE >> NEWS
Clinical factors can help determine risk of prostate cancer death after radical prostatectomy

Clinical factors including the time to biochemical recurrence following surgery can help predict the risk of prostate cancer death for patients following a radical prostatectomy, according to a study in the July 27 issue of JAMA.

Radical prostatectomy (removal of the prostate) is one of the most common treatments for prostate cancer and generally provides excellent cancer control, according to background information in the article. However, approximately 35 percent of patients will develop a prostate-specific antigen (PSA) recurrence ("biochemical recurrence") within 10 years after surgery. Due to the sensitivity of PSA to detect disease recurrence early, many patients have a long interval between biochemical recurrence and the development of local recurrence or distant metastasis.

Given the protracted natural history, the researchers had previously identified clinical variables to help stratify patients for risk of metastasis: time from surgery to biochemical recurrence, pathological Gleason score (a grading system for prostate tumors), and PSA doubling time (PSADT; the time it takes for the PSA value to double). Previous research has confirmed that a short PDADT is a risk factor for clinical progression and prostate cancer-specific death.

Stephen J. Freedland, M.D., of The Brady Urological Institute, Johns Hopkins Medicine, Baltimore, and colleagues conducted a study to 1) identify clinical factors that are associated with increased risk for prostate cancer-specific death following radical prostatectomy, and 2) to identify men who are at high risk and may benefit from aggressive treatment and as well as to identify those men who are at low risk and can be safely observed. The study included 379 men who had undergone radical prostatectomy between 1982 and 2000 and who had a biochemical recurrence. The average follow-up after surgery was 10.3 years.

The researchers found that PSA doubling time (less than 3.0 vs. 3.0-8.9 vs
'"/>

Contact: Trent Stockton
410-955-8665
JAMA and Archives Journals
26-Jul-2005


Page: 1 2

Related medicine news :

1. Clinical data suggest potential versatility of ALIMTA-based regimens in lung cancer
2. Susan G. Komen for the Cure and American Society of Clinical Oncology partner in national initiative
3. Clinical review -- A psychological approach to the management of irritable bowel syndrome
4. NHLBI Asthma Clinical Research Networks and ALA ACRC Network to present at ATS 2007
5. Clinical trial data for Perforomist Inhalation Solution presented at International ATS Conference
6. Clinical guidelines for blood conservation during cardiac procedures developed
7. Clinical trial data for Perforomist Inhalation Solution to be presented at ATS on May 20, 2007
8. Clinical trial coordinators need more financial conflict-of-interest training
9. Clinical studies evaluate potential treatments for mouth ulcers
10. NIH names Clinical Trial Units for the Microbicide Trials Network
11. Clinical Trials Units selected for newly restructured HIV/AIDS research networks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2019)... ... 2019 , ... Residents in long-term-care nursing facilities were prescribed fewer medications when ... to a study of U.S. men and women led by the staff at ... Institute (BRI) . The quality assurance study examined the high number of prescriptions ordered ...
(Date:4/18/2019)... ... April 18, 2019 , ... BNCT ... to deliver targeted radiation to cancer cells while sparing surrounding healthy tissue. NTI’s ... platforms. Engineered from the ground up for high reliability and ease of maintenance, ...
(Date:4/18/2019)... ... 18, 2019 , ... She went from learning disabled to honor roll – ... Cheryl Reilly. Those “goofy tests,” performed by Deborah Zelinsky, O.D. , founder of ... had such narrow range of visual awareness, she could only see what was directly ...
(Date:4/17/2019)... , ... April 17, 2019 , ... ... advice. However, recently, this reluctance appears to be changing. Whether because of demographic ... at least, probe their healthcare providers advice. , In the past, efforts to ...
(Date:4/17/2019)... ... , ... Fertility Centers of Illinois will recognize ... unite millions of Americans aiming to remove the stigmas and barriers associated with ... of Illinois is offering seven free physician-led webinars and free Fertility Awareness Checkups, ...
Breaking Medicine News(10 mins):
(Date:4/17/2019)... PORTSMOUTH, N.H. and BRAINTREE, Mass. (PRWEB) , ... ... ... MMS Analytics, Inc. dba MyMedicalShopper , a leading provider of ... firm and third-party administrator based in Massachusetts, are partnering to give consumers ...
(Date:4/17/2019)... ... ... Women’s Excellence in Obstetrics and Gynecology now offers same day appointments for new and ... by a provider. We believe in getting patients in right away to fix ... Dr. Jonathan Zaidan, MD, FACOG, President of Women’s Excellence. , Women’s Excellence sees patients ...
(Date:4/17/2019)... ... , ... United Breast Cancer Foundation (UBCF) hosted the incredibly successful ... 3rd. Barclays Center, home to the Brooklyn Nets and New York Islanders, is located ... which operates and manages Barclays Center, for generously donating space to help facilitate the ...
Breaking Medicine Technology:
Cached News: