HOME >> MEDICINE >> NEWS
Clinical studies evaluate potential treatments for mouth ulcers

The drug pentoxifylline appears to have limited benefit in the first-line treatment of mouth ulcers due to recurrent apthous stomatitis, according to a report in the April issue of Archives of Dermatology, one of the JAMA/Archives journals. However, a second report in the same issue finds that a cream commonly used to treat eczema may be effective in patients with another ulcer-causing mouth disease, oral erosive lichen planus.

Mouth ulcers are among the most common oral health problems, according to background information in the articles. Recurrent apthous stomatitis is characterized by recurring episodes of mouth ulcers in an otherwise healthy individual, and affects approximately 20 percent of the population. Oral erosive lichen planus is a severe inflammatory condition that causes painful wounds in the mouth. Approximately 1 percent of the population is affectedabout the same percentage as are affected by psoriasisand those who develop the condition may lose weight because of pain during eating. Few effective treatments are available for either condition.

In the first study, Martin H. Thornhill, M.B.B.S., Ph.D., of the University of Sheffield School of Clinical Dentistry, Sheffield, England, and colleagues conducted a 60-day, randomized, double-blind trial in 26 individuals (average age 33) with recurrent apthous stomatitis. In a 60-day pre-trial phase, participants kept a daily ulcer diary in which they recorded the number and size of ulcers if any were present, and also the pain associated with them on a scale of one to 10. Then, 14 patients were assigned to take one tablet containing 400 milligrams of pentoxifylline three times per day for 60 days, while 12 took three placebo pills per day. Both groups continued to keep diaries and also returned to the clinic for examinations after 30 and 60 days, and again 60 days after completing treatment.

"Patients taking pentoxifylline had less pain and reported smaller and fewer u
'"/>

Contact: Martin H. Thornhill
M.Thornhill@Sheffield.ac.uk
JAMA and Archives Journals
16-Apr-2007


Page: 1 2 3 4

Related medicine news :

1. Clinical data suggest potential versatility of ALIMTA-based regimens in lung cancer
2. Susan G. Komen for the Cure and American Society of Clinical Oncology partner in national initiative
3. Clinical review -- A psychological approach to the management of irritable bowel syndrome
4. NHLBI Asthma Clinical Research Networks and ALA ACRC Network to present at ATS 2007
5. Clinical trial data for Perforomist Inhalation Solution presented at International ATS Conference
6. Clinical guidelines for blood conservation during cardiac procedures developed
7. Clinical trial data for Perforomist Inhalation Solution to be presented at ATS on May 20, 2007
8. Clinical trial coordinators need more financial conflict-of-interest training
9. NIH names Clinical Trial Units for the Microbicide Trials Network
10. Clinical Trials Units selected for newly restructured HIV/AIDS research networks
11. Study in recent issue of Clinical Pediatrics helps pediatricians to understand discipline practices

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2019)... ... April 18, 2019 , ... It's time to try a ... Get to the root of the matter before those pesky dandruff flakes reach ... , Now you can attack dandruff before it attacks you. New Don’t ...
(Date:4/18/2019)... ... April 18, 2019 , ... Catalent, a global ... the upcoming Global Clinical Supplies Group (GCSG) 2019 US Annual Conference at the ... – May 1, 2019. , Erin Vlack, Project Manager, will present a workshop ...
(Date:4/18/2019)... ... April 18, 2019 , ... Dr. Matt Nejad is ... a full menu of cosmetic and general dental care services. Dr. Nejad is ... which relies on minimally-invasive techniques in restorative dentistry. Biomimetic dentistry uses a more ...
(Date:4/17/2019)... Fla. (PRWEB) , ... April 17, 2019 , ... With ... headlines, scientists are working to curb the death toll by looking for an alternative ... Spring 2019 National Meeting & Exposition this week. , Naloxone (often known by the ...
(Date:4/17/2019)... ... April 17, 2019 , ... ... reduce hangover symptoms. This California-made supplement was designed to lessen the negative ... now available for purchase via GotPurpleTree.com and Amazon.com . , ...
Breaking Medicine News(10 mins):
(Date:4/18/2019)... ... April 18, 2019 , ... ... of its industry-leading OPTIMASE® portfolio of biobased enzymes for medical instrument cleaning ... needs and specific challenges faced by medical instrument cleaning customers,” said Sheril ...
(Date:4/17/2019)... ATLANTA, Ga. (PRWEB) , ... April 17, 2019 ... ... solutions to healthcare providers and patients, announced today it has completed the acquisition ... Founded in 2012, Omni Holdings is the leading medical lien funding company operating ...
(Date:4/17/2019)... ... , ... Lillibridge Healthcare Services Inc., a wholly owned subsidiary ... of medical office buildings (MOBs), will sponsor and host three educational sessions featuring ... Association (BOMA) International Medical Office Buildings + Healthcare Facilities Conference May 1-3 in ...
Breaking Medicine Technology:
Cached News: