HOME >> MEDICINE >> NEWS
Clinical trials stopped early for benefit warrant skepticism from physicians

A review article in the November 2 issue of JAMA suggests clinicians ought to view with skepticism the results of randomized clinical trials stopped early because of apparent benefit.

Victor M. Montori, M.D., M.Sc., from McMaster University, Hamilton, Ontario, and colleagues conducted a review of the medical literature to identify randomized clinical trials (RCTs) of any intervention reported as having been stopped earlier than planned because of results favoring the experimental intervention.

"Of 143 RCTs stopped early for benefit, the majority (92) were published in 5 high-impact medical journals. Typically, these were industry-funded drug trials in cardiology, cancer, and human immunodeficiency virus/AIDS," the authors found. "The proportion of all RCTs published in high-impact journals that were stopped early for benefit increased from 0.5 percent in 1990 1994 to 1.2 percent in 2000 2004. On average, RCTs recruited 63 percent of the planned sample and stopped after a median (mid-point) of 13 months of follow-up, one interim analysis, and when a median of 66 patients had experienced the end point driving study termination (event)." The authors also note that "trials with fewer events yielded greater treatment effects."

The authors conclude: "RCTs stopped early for benefit are becoming more common, often fail to adequately report relevant information about the decision to stop early, and show implausibly large treatment effects, particularly when the number of events is small. These findings suggest clinicians should view the results of such trials with skepticism."

(JAMA. 2005; 294: 2203 2209. Available pre-embargo to the media at www.jamamedia.org.)

Editor's Note: Please see JAMA study for authors' funding/support information.

Editorial: When (Not) to Stop a Clinical Trial for Benefit

In an accompanying editorial, Stuart J. Pocock, Ph.D., from the London Sch
'"/>

Contact: Susan Emigh
905-525-9140
JAMA and Archives Journals
1-Nov-2005


Page: 1 2

Related medicine news :

1. Clinical data suggest potential versatility of ALIMTA-based regimens in lung cancer
2. Susan G. Komen for the Cure and American Society of Clinical Oncology partner in national initiative
3. Clinical review -- A psychological approach to the management of irritable bowel syndrome
4. NHLBI Asthma Clinical Research Networks and ALA ACRC Network to present at ATS 2007
5. Clinical trial data for Perforomist Inhalation Solution presented at International ATS Conference
6. Clinical guidelines for blood conservation during cardiac procedures developed
7. Clinical trial data for Perforomist Inhalation Solution to be presented at ATS on May 20, 2007
8. Clinical trial coordinators need more financial conflict-of-interest training
9. Clinical studies evaluate potential treatments for mouth ulcers
10. NIH names Clinical Trial Units for the Microbicide Trials Network
11. Clinical Trials Units selected for newly restructured HIV/AIDS research networks

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/1/2020)... ... 2020 , ... Dr. Kiran Gill is a Board Certified ... face, breast, and body. In 2018, she founded Aesthetics in Plastic Surgery by ... practice in Southwest Florida. Dr. Gill and her team offer surgical and non-surgical ...
(Date:8/31/2020)... ... August 31, 2020 , ... Want to get moving, break up ... Research Foundation (CPARF) is thrilled to launch its fourth annual STEPtember campaign in the ... challenge, STEPtember meets everyone wherever they are at this moment — encouraging people to ...
(Date:8/31/2020)... ... 2020 , ... A Cure for Covid-19 “PTS” with Mediation & Hypnosis , At this ... state of panic, experiencing deep anxiety, immense stress, and right now are needing serious relief ... most people on the planet are experiencing a great degree of emotional discomfort, be it ...
(Date:8/28/2020)... ... 2020 , ... Ernst & Young LLP (EY US) today ... The Year® 2020 Florida Award finalist. Now in its 34th year, the Entrepreneur ... and prosperity as they build and sustain successful businesses that transform our world. ...
(Date:8/28/2020)... ... 28, 2020 , ... Ziegler, a specialty investment bank, is ... Synchronous Health, a tech-enabled behavioral health and well-being solutions provider. , Synchronous ... artificial intelligence (AI) to increase access and quality of behavioral health services, and ...
Breaking Medicine News(10 mins):
(Date:8/28/2020)... ... August 28, 2020 , ... ... care medical centers in Florida and San Antonio is happy to announce that ... medical centers. , In this capacity he will serve as community advisor, advertising ...
(Date:8/28/2020)... , ... August 28, 2020 , ... ... and aesthetic beauty, bringing a unique perspective and approach. Armed with her qualifications ... ventured out to share her knowledge of the human body with the nation ...
(Date:8/27/2020)... (PRWEB) , ... August 27, 2020 , ... Austin Oral ... – is pleased to announce Dr. David Szalay, DDS, MD, has joined the practice. ... patients in the new Pflugerville office, which is scheduled to open this fall. The ...
Breaking Medicine Technology:
Cached News: