Dr. Frumento and his team observed 96 non-diabetic CABG patients, divided into three groups: 28 received a full dose of aprotinin, 33 received a half dose, and 35 received no aprotinin. Blood was taken and analyzed at three intervals - after the patients received anesthesia, 30 minutes into CABG surgery, and after the surgery. Previous in vivo trials conducted by other researchers have repeatedly demonstrated the drug's effectiveness in reducing hyperglycemia in animals but this was the first study of its kind in humans.
The study led by Dr. Robert J. Frumento, "Effect of Aprotinin on Glucose Levels and Insulin Resistance in Patients Undergoing Cardiac Surgery", was funded by the department of anesthesiology of Columbia University College of Physicians and Surgeons. Dr. Frumento's research team includes Columbia University Medical Center investigators Sanford M. Littwin, M.D., assistant clinical professor of anesthesiology, and Jack S. Shanewise, M.D., professor of clinical anesthesiology and director of cardiothoracic anesthesia division. Elliott Bennett-Guerrero, M.D., former director of cardiac anesthesiology at Columbia University and who has since joined the Duke Clinical Research Institute, also contributed to the research.