The data, published in the October edition of Nutrition and Cancer, showed Zyflamend, a patented formulation from New Chapter, has the ability, in vitro, to reduce prostate cancer cell proliferation by as much as 78 percent and to induce cancer cell death or apoptosis.

The research confirms Zyflamend has COX-1 and COX-2 anti-inflammatory effects, although its anti-cancer affects against prostate cancer were independent of COX-2 inhibition, supporting the postulation that some prostate cancer cells are not affected by COX-2 inflammation.

"These results were particularly surprising and show great promise in the fight against prostate cancer," said researcher Dr. Debra L. Bemis of the Columbia University Department of Urology. "We hope that the magnitude of benefits shown in this research will be confirmed in the larger scale trial already in progress."

Based on this research, Zyflamend shows value in early therapy for prostate cancer patients. COX inhibitors have also shown value for prostate cancer patients, but data from recent trials of selective COX-2 inhibitors such as sulindac (Clinoril) and celecoxib (Celebrex), suggest that use of these drugs might have adverse cardiovascular effects. The more widely utilized general COX inhibitor, aspirin, is not associated with these negative side effects and, instead, has well-established beneficial effects for individuals with cardiovascular disease. Zyflamend has a biochemical action profile that resembles aspirin more than these selective COX-2 inhibitors.

Dr. Bemis added: "Zyflamend is derived from natural herbal sources and is readily available in health food and nutritional supplement stores. Given the impressive d
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Contact: Craig LeMoult
cel2113@columbia.edu
212-920-9652
Columbia University Medical Center
9-Nov-2005