HOME >> MEDICINE >> NEWS
Combating fatigue associated with liver disease

Fatigue affects up to 85 percent of patients with primary biliary cirrhosis (PBC), interfering with their quality of life and limiting their activities. Although several drugs have previously been studied, none have proven effective and there is currently no known treatment for it.

In a study led by Jeremy J. Theal, M.D. of the University of Toronto and published in the June 2005 issue of Hepatology, researchers examined the effects of ondansetron (an anti-nausea drug commonly used to treat nausea during chemotherapy) on fatigue associated with PBC, an inflammation of the bile ducts in the liver that leads to cirrhosis. Fatigue is often associated with depression, which may be caused by abnormalities in serotonin transmission; ondansetron helps regulate serotonin levels, which suggests its potential as a treatment for fatigue and depression.

Hepatology, the official journal of the American Association for the Study of Liver Diseases (AASLD), published by John Wiley & Sons, Inc. is available online via Wiley InterScience at http://www.interscience.wiley.com/journal/hepatology.

A total of 54 patients from three Canadian centers (Toronto, Montreal, and Calgary) were included in a randomized, double blind placebo-controlled crossover trial, in which they received the drug in one four week period and a placebo in the other. The crossover design was chosen because fatigue is a subjective symptom and taking both the drug and the placebo in two separate blinded periods allowed patients to serve as their own controls. In addition to a diagnosis of PBC, patients had to score at least a 4 on the Fatigue Survey Score survey (FSS), a scoring system used to evaluate fatigue in patients with PBC. Patients received either a placebo in period 1 and ondansetron in period 2 or vice versa, but did not know which group they were in.

Patients taking ondansetron in period 1 showed the same
'"/>

Contact: David Greenberg
dgreenbe@wiley.com
201-748-6484
John Wiley & Sons, Inc.
24-May-2005


Page: 1 2

Related medicine news :

1. Combating depression in women with nursing interventions
2. Rochester spreads knowledge of cancer-related fatigue
3. Herb shows potential to reduce cancer-related fatigue
4. Keeping pain and fatigue on the run
5. Chronic fatigue syndrome impairs a persons slow wave activity during sleep
6. Take fatigue seriously, says University of Alberta researcher
7. Low impact aerobic exercise reduces fatigue in auto-immune conditions says multi-study review
8. Stress, childhood trauma linked to chronic fatigue syndrome in adults
9. Study of twins finds genetic link to fatigue
10. Residents report less fatigue, better care under 80-hour work week mandate
11. Persistent fatigue may be the best way to predict onset of postpartum depression

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Combating fatigue associated with liver disease

(Date:3/5/2015)... At the 7th Annual Mississippi Addiction Conference ... met today in Jackson, Mississippi to listen to keynote ... numerous respected speakers will be William S. Jacobs, ... pain medications have had in today’s opiate overdose and ... is hard to believe that much of the current ...
(Date:3/5/2015)... University of Western States (UWS), ... has launched a new center of excellence to ... Northwest Center for Lifestyle and Functional Medicine aim ... and conduct research in the areas of lifestyle ... The center will target efforts on the UWS ...
(Date:3/5/2015)... NY (PRWEB) March 05, 2015 Dr. ... Surgeon ( http://www.orthopedicsurgeonnyc.com ) has been named by ... New York Metro area. Dr. Glashow has been selected ... authoritative guide to the top specialty care doctors in ... The prestigious Castle Connolly program, which carefully screens and ...
(Date:3/5/2015)... 05, 2015 Today, Earth Source ... on 100% pollution-free electricity through a partnership with ... As an Arcadia Power Clean Energy Partner, ESO ... Power Partnership requirements, joining national brands such as ... clean energy. Earth Source Organics joins a growing ...
(Date:3/5/2015)... Think it’s tough to get kids to ... them to brush their teeth. That’s a finding from a ... Delta Dental(1) in conjunction with National Parenting Month in March. ... kids to brush their teeth is one of the most ... higher than getting children to eat vegetables regularly (42 percent) ...
Breaking Medicine News(10 mins):Health News:National Addiction Treatment Expert William S. “Bill” Jacobs, Md Speaks At Prestigious 7th Annual Mississippi Addiction Conference 2Health News:National Addiction Treatment Expert William S. “Bill” Jacobs, Md Speaks At Prestigious 7th Annual Mississippi Addiction Conference 3Health News:University of Western States Launches Northwest Center for Lifestyle and Functional Medicine 2Health News:Dr. Jonathan Glashow, NYC Orthopedic Surgeon, Named Top Doctor: New York Metro Area 2Health News:Earth Source Organics to Run on Clean Energy from Arcadia Power 2Health News:Delta Dental Survey Says Parents Have Harder Time Getting Kids to Brush than to Eat Vegetables 2Health News:Delta Dental Survey Says Parents Have Harder Time Getting Kids to Brush than to Eat Vegetables 3
(Date:3/5/2015)... , March 5, 2015  ContraVir Pharmaceuticals, Inc. (NASDAQ: ... the development and commercialization of targeted antiviral therapies, announced ... Annual ROTH Conference, to be held March 8-11, ... James Sapirstein , Chief Executive Officer, ... his live presentation and will be available to participate ...
(Date:3/5/2015)... Calif. , March 5, 2015  Asterias Biotherapeutics, ... the emerging field of regenerative medicine, announced today that ... the nation,s top rehabilitation hospitals for spinal cord injury ... 1/2a clinical trial of AST-OPC1 (oligodendrocyte progenitor cells) in ... spinal cord injury (SCI). The Phase ...
(Date:3/5/2015)... YORK and VANCOUVER, British Columbia ... (CSE: BUX FSE: 20B OTCQB: BMKDF) -- The ultimate ... an assay that is capable of detecting tumors before ... forty years, the development of such an assay has ... in academia and industry. Although many breakthrough diagnostics have ...
Breaking Medicine Technology:ContraVir to Present at 27th Annual ROTH Conference 2Asterias Biotherapeutics Initiates Patient Enrollment for Phase 1/2a Clinical Trial of AST-OPC1 in Newly Injured People with Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Initiates Patient Enrollment for Phase 1/2a Clinical Trial of AST-OPC1 in Newly Injured People with Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Initiates Patient Enrollment for Phase 1/2a Clinical Trial of AST-OPC1 in Newly Injured People with Complete Cervical Spinal Cord Injury 4New Cancer Diagnostic Primed to Change the Industry 2New Cancer Diagnostic Primed to Change the Industry 3New Cancer Diagnostic Primed to Change the Industry 4
Cached News: