HOME >> MEDICINE >> NEWS
Combating fatigue associated with liver disease

Fatigue affects up to 85 percent of patients with primary biliary cirrhosis (PBC), interfering with their quality of life and limiting their activities. Although several drugs have previously been studied, none have proven effective and there is currently no known treatment for it.

In a study led by Jeremy J. Theal, M.D. of the University of Toronto and published in the June 2005 issue of Hepatology, researchers examined the effects of ondansetron (an anti-nausea drug commonly used to treat nausea during chemotherapy) on fatigue associated with PBC, an inflammation of the bile ducts in the liver that leads to cirrhosis. Fatigue is often associated with depression, which may be caused by abnormalities in serotonin transmission; ondansetron helps regulate serotonin levels, which suggests its potential as a treatment for fatigue and depression.

Hepatology, the official journal of the American Association for the Study of Liver Diseases (AASLD), published by John Wiley & Sons, Inc. is available online via Wiley InterScience at http://www.interscience.wiley.com/journal/hepatology.

A total of 54 patients from three Canadian centers (Toronto, Montreal, and Calgary) were included in a randomized, double blind placebo-controlled crossover trial, in which they received the drug in one four week period and a placebo in the other. The crossover design was chosen because fatigue is a subjective symptom and taking both the drug and the placebo in two separate blinded periods allowed patients to serve as their own controls. In addition to a diagnosis of PBC, patients had to score at least a 4 on the Fatigue Survey Score survey (FSS), a scoring system used to evaluate fatigue in patients with PBC. Patients received either a placebo in period 1 and ondansetron in period 2 or vice versa, but did not know which group they were in.

Patients taking ondansetron in period 1 showed the same
'"/>

Contact: David Greenberg
dgreenbe@wiley.com
201-748-6484
John Wiley & Sons, Inc.
24-May-2005


Page: 1 2

Related medicine news :

1. Combating depression in women with nursing interventions
2. Rochester spreads knowledge of cancer-related fatigue
3. Herb shows potential to reduce cancer-related fatigue
4. Keeping pain and fatigue on the run
5. Chronic fatigue syndrome impairs a persons slow wave activity during sleep
6. Take fatigue seriously, says University of Alberta researcher
7. Low impact aerobic exercise reduces fatigue in auto-immune conditions says multi-study review
8. Stress, childhood trauma linked to chronic fatigue syndrome in adults
9. Study of twins finds genetic link to fatigue
10. Residents report less fatigue, better care under 80-hour work week mandate
11. Persistent fatigue may be the best way to predict onset of postpartum depression

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Combating fatigue associated with liver disease

(Date:5/28/2015)... Falls Church, VA (PRWEB) May 29, 2015 ... Requirements, Best Practices and Innovative Approaches, **FDAnews Webinar**, ... p.m. EDT, http://www.fdanews.com/MDCybersecurityQA , Network connectivity ... devices, but it also exposes a minefield of ... condition to healthcare professionals, but can manufacturers be ...
(Date:5/28/2015)... On Monday, June 1, KORT, The Best in Rehab, ... Shelbyville, Kentucky . Clinic Director, Chad Flickinger, PT, MPT, CES, ... , “ Shelbyville is a growing community and KORT ... better serve the residents of Shelby County. At KORT, we ... possible by providing accessible and immediate care in a very ...
(Date:5/28/2015)... 29, 2015 Recently, KORT Richmond, 5006 Atwood ... regain their quality of life. The program works with those ... one for years, but are still having difficulty. , According ... million people living with limb loss in the United States. ... including diabetes and peripheral arterial disease – trauma (45%) and ...
(Date:5/28/2015)... Calgary, AB (PRWEB) May 28, 2015 ... the world and all over the United States. There ... of heart disease, who can experience symptoms of angina ... cardiac medications, heart stents and/or bypass surgery. , “No ... angina due to coronary artery disease that is considered ...
(Date:5/28/2015)... May 28, 2015 Cosmetic Town Journal ... surgeons and patients alike. You can find information on ... and body contouring. Readers can directly connect to the ... experience from the ground up. , The continued addition ... the community to grow and getting it closer to ...
Breaking Medicine News(10 mins):Health News:FDAnews Announces — Medical Device Cybersecurity Quality Assurance: Requirements, Best Practices and Innovative Approaches Webinar, June 23, 2015 2Health News:FDAnews Announces — Medical Device Cybersecurity Quality Assurance: Requirements, Best Practices and Innovative Approaches Webinar, June 23, 2015 3Health News:KORT Physical Therapy Opens New Clinic In Shelbyville, Kentucky 2Health News:KORT Physical Therapy Opens New Clinic In Shelbyville, Kentucky 3Health News:KORT Richmond Physical Therapy Adds New Program to Help Amputees 2Health News:External Counterpulsation (EECP/ECP) a New Heart Disease Therapy Helps People of Calgary with Unstable Angina 2Health News:New York Cosmetic Doctors Now in Cosmetic Town 2Health News:New York Cosmetic Doctors Now in Cosmetic Town 3
(Date:5/28/2015)... May 28, 2015  Eli Lilly and Company (NYSE: ... announced cash tender offer for up to $1.6 billion aggregate ... Holders of notes who tendered, and did not validly ... New York City time, on May 27, 2015 ... by Lilly, are eligible to receive the total consideration. The ...
(Date:5/28/2015)... , May 28, 2015 Zimmer Holdings, ... it has finalized agreements with buyers to divest in ... Unicompartmental High-Flex Knee System assets, Biomet Discovery® Elbow System ... are in furtherance of Zimmer,s pending acquisition of Biomet, ... Zimmer continues to work constructively with the Bureau of ...
(Date:5/28/2015)... , May 28, 2015 /PRNewswire/ - ESSA Pharma Inc. ... for the second quarter and three and six months ended ... Canadian dollars and in accordance with International Financial Reporting Standards ... recorded a net loss of $5.9 million ($0.35 per common ... compared to a net loss of $0.4 million ($0.03 per ...
Breaking Medicine Technology:Lilly Announces the Pricing Terms of Its Cash Tender Offer for Up to $1.6 Billion Aggregate Principal Amount of Its Outstanding Debt Securities 2Lilly Announces the Pricing Terms of Its Cash Tender Offer for Up to $1.6 Billion Aggregate Principal Amount of Its Outstanding Debt Securities 3Lilly Announces the Pricing Terms of Its Cash Tender Offer for Up to $1.6 Billion Aggregate Principal Amount of Its Outstanding Debt Securities 4Lilly Announces the Pricing Terms of Its Cash Tender Offer for Up to $1.6 Billion Aggregate Principal Amount of Its Outstanding Debt Securities 5Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 2Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 3Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 4Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 5Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 6Essa Pharma Inc. Reports Second Quarter 2015 Financial Results 2Essa Pharma Inc. Reports Second Quarter 2015 Financial Results 3Essa Pharma Inc. Reports Second Quarter 2015 Financial Results 4Essa Pharma Inc. Reports Second Quarter 2015 Financial Results 5
Cached News: