HOME >> MEDICINE >> NEWS
Combating fatigue associated with liver disease

Fatigue affects up to 85 percent of patients with primary biliary cirrhosis (PBC), interfering with their quality of life and limiting their activities. Although several drugs have previously been studied, none have proven effective and there is currently no known treatment for it.

In a study led by Jeremy J. Theal, M.D. of the University of Toronto and published in the June 2005 issue of Hepatology, researchers examined the effects of ondansetron (an anti-nausea drug commonly used to treat nausea during chemotherapy) on fatigue associated with PBC, an inflammation of the bile ducts in the liver that leads to cirrhosis. Fatigue is often associated with depression, which may be caused by abnormalities in serotonin transmission; ondansetron helps regulate serotonin levels, which suggests its potential as a treatment for fatigue and depression.

Hepatology, the official journal of the American Association for the Study of Liver Diseases (AASLD), published by John Wiley & Sons, Inc. is available online via Wiley InterScience at http://www.interscience.wiley.com/journal/hepatology.

A total of 54 patients from three Canadian centers (Toronto, Montreal, and Calgary) were included in a randomized, double blind placebo-controlled crossover trial, in which they received the drug in one four week period and a placebo in the other. The crossover design was chosen because fatigue is a subjective symptom and taking both the drug and the placebo in two separate blinded periods allowed patients to serve as their own controls. In addition to a diagnosis of PBC, patients had to score at least a 4 on the Fatigue Survey Score survey (FSS), a scoring system used to evaluate fatigue in patients with PBC. Patients received either a placebo in period 1 and ondansetron in period 2 or vice versa, but did not know which group they were in.

Patients taking ondansetron in period 1 showed the same
'"/>

Contact: David Greenberg
dgreenbe@wiley.com
201-748-6484
John Wiley & Sons, Inc.
24-May-2005


Page: 1 2

Related medicine news :

1. Combating depression in women with nursing interventions
2. Rochester spreads knowledge of cancer-related fatigue
3. Herb shows potential to reduce cancer-related fatigue
4. Keeping pain and fatigue on the run
5. Chronic fatigue syndrome impairs a persons slow wave activity during sleep
6. Take fatigue seriously, says University of Alberta researcher
7. Low impact aerobic exercise reduces fatigue in auto-immune conditions says multi-study review
8. Stress, childhood trauma linked to chronic fatigue syndrome in adults
9. Study of twins finds genetic link to fatigue
10. Residents report less fatigue, better care under 80-hour work week mandate
11. Persistent fatigue may be the best way to predict onset of postpartum depression

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Combating fatigue associated with liver disease

(Date:11/23/2014)... (PRWEB) November 23, 2014 AngelWeddingDress.com ... worldwide a new selection of beach wedding dresses. “If ... best prices, visit AngelWeddingDress.com as soon as possible. Here ... workmanship.” The sales manager says. , Holding a big ... girl. And choosing a beautiful beach wedding dress is ...
(Date:11/23/2014)... Syngenta lawsuits are now being investigated ... and agribusinesses that have allegedly incurred significant financial damages ... and Agrisure Duracade, genetically modified (GMO) corn seed ... in China. According to a report from Bloomberg News, ... corn imports. Because China is the third-largest American corn ...
(Date:11/22/2014)... SC (PRWEB) November 23, 2014 Every ... to their communities. AlignLife experience rapid growth in the ... a very unique opportunity. AlignLife of Simpsonville ... AlignLife offices for their first annual Toy Drive. These ... charity they would support with this year's toy drive. ...
(Date:11/22/2014)... Recently, UWDress.com, a successful wedding dress shop, has released its ... order to prepare for the wedding season. All of them ... , UWDress.com is a reliable company that has many years ... items -- formal wedding guest attire. This new collection comes ... and princess. As one of the leading companies in the ...
(Date:11/22/2014)... Today, Dylan Queen, a renowned brand in ... dresses; the business offers a wide range of special ... worldwide, allowing them to create multiple looks easily. , ... new collection of chic wedding dresses has been prepared ... at discounted rates now. Dylan Queen can always create ...
Breaking Medicine News(10 mins):Health News:Beach Wedding Dresses Added to Outstanding Online Dress Company AngelWeddingDress.com 2Health News:Syngenta Lawsuits Being Investigated by Wright & Schulte LLC, Following China’s Rejection of Corn Shipments Tainted with Unapproved GMO Seed 2Health News:Syngenta Lawsuits Being Investigated by Wright & Schulte LLC, Following China’s Rejection of Corn Shipments Tainted with Unapproved GMO Seed 3Health News:Greenville Area AlignLife Offices Join Together for a Local Toy Drive 2Health News:Formal Wedding Guest Attire Added to UWDress.com 2Health News:Dylan Queen Introduces Its New Wedding Dresses 2
(Date:11/21/2014)... SAN CLEMENTE, Calif. , Nov. 21, 2014 /PRNewswire/ ... Lab Coats and Performance Scrubs carried out a new ... the medical industry,s very first "limited edition" lab ... the first female professors of surgery in the world. ... departure from its unisex predecessors, with a sleek envelope ...
(Date:11/21/2014)... EVANSTON, Ill. , Nov. 21, 2014  Heated ... prescription drug prices – from cancer treatments to Gilead,s ... and pharmaceutical leaders around the world questioning what it ... quality of care. And while drug ... the pharmaceutical industry – from both a general business ...
(Date:11/21/2014)... 2014 Clementia Pharmaceuticals, ... dass die Europäische Arzneimittel-Agentur (European Medicines ... Orphan-Medizinprodukt an Palovarotene vergeben hat, den ... von Fibrodysplasia ossificans progressiva (FOP). FOP ... Krankheit, die von schmerzhaften, wiederkehrenden Episoden ...
Breaking Medicine Technology:Medelita Introduces Medical Industry's First Limited Edition Women's Designer Lab Coat 2"The Price of Global Health" Tackles Worldwide Drug-Pricing Debate 2"The Price of Global Health" Tackles Worldwide Drug-Pricing Debate 3"The Price of Global Health" Tackles Worldwide Drug-Pricing Debate 4"The Price of Global Health" Tackles Worldwide Drug-Pricing Debate 5Clementia Pharmaceuticals erhält EMA-Kennzeichnung als Orphan-Medizin für Palovarotene zur Behandlung von Fibrodysplasia ossificans progressiva 2Clementia Pharmaceuticals erhält EMA-Kennzeichnung als Orphan-Medizin für Palovarotene zur Behandlung von Fibrodysplasia ossificans progressiva 3
Cached News: