Combination vaccine produces lower immune response than vaccines administered separately

A combination vaccine developed to reduce the number of vaccines infants receive appears to provide less immunity than the vaccines administered individually, according to a study in the April 13 issue of JAMA.

The development of immunogenic vaccines against major diseases of childhood has dramatically decreased the rates of invasive disease, according to background information in the article. Since the introduction of a monovalent serogroup C meningococcal glycoconjugate vaccine (MenC) into the United Kingdom routine immunization schedule in November 1999, group C meningococcal disease has decreased by 87 percent in the ages targeted for vaccination, with estimated vaccine efficacy of 90 percent. Within 2 years of the introduction of a 7-valent pneumococcal glycoconjugate vaccine into the recommended infant schedule in the United States, there was a 69 percent reduction in culture-positive invasive pneumococcal disease in children younger than 2 years.

The advent of these efficacious and safe vaccines has increased pressure on crowded infant immunization schedules. Infants in the United States receive up to 20 separate vaccine injections over 5 immunization encounters at ages 2, 4, 6, 12, and 18 months to protect against disease due to hepatitis B, diphtheria, tetanus, pertussis, polio, measles, mumps, rubella, varicella, H influenzae type b, and pneumococcus. The inclusion of MenC would add a further 3 to 4 doses to the U.S. regimen. The development of combination vaccines has become a priority. The combining of pneumococcal and meningococcal conjugate vaccines has the potential to spare U.S. infants up to 4 extra injections by age 18 months and to decrease parental and clinician concerns about the number of vaccinations in early childhood.

Jim P. Buttery, F.R.A.C.P., formerly of the University of Oxford, Churchill Hospital, Headington, Oxford, U.K., and colleagues conducted a study to determine the immunogenicity and safety of a combinati

Contact: Jim P. Buttery, F.R.A.C.P.
JAMA and Archives Journals

Page: 1 2

Related medicine news :

1. Combination treatment stymies breast cancer growth
2. Combination therapy spares some head and neck patients from surgery
3. Combination of personality traits increases risk for heart disease
4. Combination therapy may improve survival for pancreatic cancer
5. Combination therapy with a monocloncal antibody and a vaccine leads to tumor rejection
6. Combination of three new, high-powered MRI systems at PENN is a first in the US
7. Dynamic duo: Combination therapy reverses type 1 diabetes
8. Combination of interventions can substantially reduce incidence of malaria in people with HIV
9. Combination therapy improves AIDS-related lymphoma outcome
10. Combination treatment for brain cancer not detrimental to patients quality of life
11. Combination microbicides protect monkeys against HIV-like virus

Post Your Comments:

(Date:11/30/2015)... ... 2015 , ... At Grand Dental PC, their priority is to deliver quality ... dental problems, you need to turn to a dentist who listens and responds; an ... a friendly dentist who counsels you on the best ways to maintain and improve ...
(Date:11/30/2015)... ... November 30, 2015 , ... Dr. Seth D. Margulies specializes in orthodontics and ... Dr. Margulies to experience the best available orthodontic experience in the area. Dr. ... Dentist"! , Orthodontics is the branch of dentistry that specializes in the diagnosis, prevention, ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... study by UPMC and KingMed Diagnostics researchers. Their review ... found that consultation with UPMC pathologists resulted in significantly altered treatment plans for ...
(Date:11/30/2015)... ... November 30, 2015 , ... Two years ago, Debbie Gregory, the CEO ... Lynch Foundation, learning Transcendental Meditation (TM). After encouraging a number of veterans to ... that she could talk the talk. , TM is becoming one of the best ...
(Date:11/30/2015)... , ... November 30, 2015 , ... ... (ASI) as their exclusive channel partner for the Nutraceutical Specialties products into oral ... the US, effective immediately. , “We are pleased to announce our expanded ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... AUSTIN, Texas , Nov. 30, 2015  Hanger, ... the amendment and restatement of the terms of its ... "Consent Solicitation") relating to its $200,000,000 aggregate principal amount ... among other things, (i) the consent fees payable pursuant ... rate on the Notes and (iii) the expiration date ...
(Date:11/30/2015)... Mexico Healthcare and Life Sciences Report 2015 . --> ... Pharmaboardroom releases its new 98-page Mexico Healthcare and Life Sciences ... country of over 122 million people. --> Latin ... --> It offers companies, investors, policymakers, and stakeholders with an ... largest pharma and healthcare market in Latin America ...
(Date:11/29/2015)... , Nov. 29, 2015   Royal Philips  (NYSE: ... radiology solutions at the 2015 Radiological Society of North ... at McCormick Place in Chicago . ... experience the company,s broad portfolio of integrated Diagnostic Imaging, ... to increase clinical performance, improve workflow and create a ...
Breaking Medicine Technology:
Cached News: