Combo drug controls hypertension in hard-to-treat patients

A multi-center study of a pill that combines two drugs for hypertension shows significant benefit for people with hard-to-control high blood pressure. The study, conducted at the University of Maryland School of Medicine and 118 other sites, was focused on bringing down systolic blood pressure, the top number in a blood pressure reading, which is the more difficult number to bring down. The results of the study, called the INCLUSIVE trial, will be presented at the American Society for Hypertension conference in San Francisco on Tuesday, May 17, 2005.

"The percentage of patients whose blood pressure was controlled in this study was much higher compared to other combination therapy trials," says one of the study's two principal investigators, Elijah Saunders, M.D., professor of medicine at the University of Maryland School of Medicine and a cardiologist and hypertension expert at the University of Maryland Medical Center.

"This was the first large-scale hypertension study to include such a broad range of patient groups," says Dr. Saunders. "We found that this combination therapy reduced systolic blood pressure to a desirable level in 77 percent of the patients, and 83 percent of the patients in our study achieved an acceptable diastolic blood pressure. These results are significant," he adds.

The study began with a total of 1,005 participants with high blood pressure. A broad range of people participated in the study in terms of age and ethnicity. Half of them were women. All were given a diuretic alone for two weeks at the start of the trial. Nearly 30 percent of participants responded to this one drug, so they were eliminated from further participation.

The remaining 736 people were given the combination pill of irbesartan (an angiotensin II receptor blocker) and a diuretic, hydrochlorothiazide, in increasingly stronger doses until their blood pressure reached a desirable goal. At the end of 18 weeks, the participants' systolic b

Contact: Bill Seiler
University of Maryland Medical Center

Page: 1 2 3

Related medicine news :

1. Cost-benefit analysis: Combo treatment costs more, saves money later
2. As heart procedures increase, quality and cost controls are critical
3. Identified: DNA that controls the malaria parasites disguise mechanism
4. Radiation, chemotherapy before surgery controls rectal cancer
5. Gene that controls the severity of asthma identified
6. Diabetes drug controls blood glucose, cardiac risk
7. Scientists identify protein that controls cancer cells
8. Effectiveness of first renin inhibitor drug for treating hypertension is limited
9. Racial disparities in treatment of patients with cirrhosis and complications of portal hypertension
10. Liver stiffness indicates portal hypertension
11. CRP liver protein induces hypertension, UT Southwestern researchers have found

Post Your Comments:

(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... ... largest non-profit organization devoted exclusively to funding innovative lymphoma research and serving the ... services – today announced the 10th Anniversary of Blood Cancer Awareness Month (BCAM) ...
(Date:8/31/2020)... ... August 31, 2020 , ... Colorado ... through high-quality, career-relevant, and affordable online education – is proud to announce its ... Among the first of its kind in the nation, the 60-credit hour program ...
(Date:8/31/2020)... ... 31, 2020 , ... Dr. Chang has over 20 years ... other developmental disabilities, as well as supporting staff in caring for patients and ... consultation, and staff development. She joined the company in 2015 as Chief of ...
(Date:8/28/2020)... ... August 28, 2020 , ... The ... a customized Lighthouse Health & Wellness mobile app and web-portal. NCPCV received a ... Solutions Foundation awards grants each year to organizations, such as Destination Imagination, which ...
(Date:8/27/2020)... ... August 27, 2020 , ... ... the Walk-in Dermatology team in its Greenvale, New York location. , Loren ... Skin Care Institute. She is certified in chemical peels, microdermabrasion, Hydrafacial MD, dermaplaning, ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... ... ... While coronavirus cases continue to increase across the country, blood drives are being ... about 80% of blood donations are made at drives hosted by these groups, the ... to ensure blood products are readily available for patients. , Those interested can ...
(Date:8/31/2020)... ... August 31, 2020 , ... Welltech1, the ... that they have invested $400,000 in PopBase, one of two start-ups that beat ... Global Wellness Institute (GWI). , The competition was part of the GWI’s ...
(Date:8/31/2020)... ... 31, 2020 , ... Cloudticity announced today that Network Products ... winner in the 15th Annual 2020 Network PG’s IT World Awards®. , The ... Network Products Guide honoring achievements of world’s best in organizational performance, product and ...
Breaking Medicine Technology:
Cached News: