Common PTSD drug is no more effective than placebo

women or older versus younger veterans. In addition, the subjects who took guanfacine had significantly more somnolence, lightheadedness, and dry mouth than those who took placebo.

The study authors conclude, These results do not support the use of alpha 2 agonists in veterans with chronic PTSD.

Neylan speculates that instead of lowering the overall level of norepinephrine, a more effective approach might be to inhibit the ability of brain cells to respond to the neurotransmitter. He notes that this is the action of prazosin, a blood pressure medication that has been found by other researchers to decrease the incidence of nightmares in combat veterans with PTSD.


Contact: Steve Tokar
415-221-4810 x5202
University of California - San Francisco

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