HOME >> MEDICINE >> NEWS
Common blood pressure drug treats muscular dystrophy in mice

Researchers at Johns Hopkins have shown that a drug commonly used to lower blood pressure reverses muscle wasting in genetically engineered mice with Marfan syndrome and also prevents muscle degeneration in mice with Duchenne muscular dystrophy. The results are reported online this week at Nature Medicine.

In 2006, a team led by Harry "Hal" Dietz, M.D., discovered that treating Marfan mice with losartan (Cozaar) dramatically strengthens the aorta, the major artery carrying blood away from the heart, and prevents enlargement and risk of bursting, a condition known as aortic aneurysm. A clinical trial to assess how effective losartan is for treating people with Marfan will launch within weeks.

"In addition to the aortic defect, children with severe Marfan syndrome often have very small, weak muscles, and adults with Marfan often can't gain muscle mass despite adequate nutrition and exercise," explains Dietz, a professor at the McKusick-Nathans Institute of Genetic Medicine at The Johns Hopkins University School of Medicine.

Dietz and his colleagues had previously discovered that many features of Marfan syndrome, including aortic aneurysm, arise from excess activity of TGF-beta, a protein that instructs cell behavior. Marfan mice have muscles containing much scar tissue between unusually small muscle fibers, which also show evidence of too much TGF-beta activity. Dietz's team reasoned that blocking the activity of TGF-beta might restore normal muscle structure and function.

First, the research team injected Marfan mice with a protein that binds TGF-beta and renders it inactive. This TGF-beta-blocking protein caused muscle fibers in these mice to grow bigger than those in untreated Marfan mice. "Not only did the muscles look bigger and better under the microscope," says Dietz, "the mice were also stronger and showed reduced fatigue."

The team then treated Marfan mice with losartan, a medication known to be safe in
'"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
21-Jan-2007


Page: 1 2 3

Related medicine news :

1. Commonly used drug offers promise for premature babies
2. Commonly used pain medications do not prevent Alzheimers disease
3. Common anesthetic may induce cell death, generation of Alzheimers-associated protein
4. Common PTSD drug is no more effective than placebo
5. Common cold may be just a fingertip away due to environmental contamination
6. Commonwealth Fund commission says the US health care system needs thorough transformation
7. Commonly recommended sedative does not improve infant sleep
8. Common asthma inhaler causing deaths, researchers assert
9. Common painkillers associated with increased risk of first hospital admission for heart failure
10. Commonly used blood pressure medication prevents aortic aneurysm in mice with Marfan syndrome
11. Common osteoporosis treatment may help men with prostate cancer suffering from bone loss

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/24/2017)... Cruz, California (PRWEB) , ... September 24, 2017 , ... ... wells. , Private ground water wells can provide clean, safe, potable water. However, ... septic tanks and earthquake faults, leading to disease and illness. , The EPA ...
(Date:9/24/2017)... ... ... and I”, a young boy was walking home and feeling down about himself. He didn’t ... The new friend says he can do whatever he wants to do if he puts his ... way he is. God created him with special talents and gifts. We see his internal ...
(Date:9/24/2017)... ... ... Gospel Truth Of The Bible: The Other Sheep”: the ceremonial laws of Moses and the ... is the creation of published author, Maurice Caines. Maurice Caines resides in the sunny ... a member of the Seventh-day Adventist Church for many years. He was previously a ...
(Date:9/23/2017)... ... September 23, 2017 , ... Silicon Valley Hair Institute, the leading hair transplant ... post focused on the ARTAS® hair transplant system and the younger demographic. As many ... most technologically sophisticated methods of hair restoration. , “It can be emotionally difficult for ...
(Date:9/22/2017)... ... , ... MEDIA OPPORTUNITY: , Save Our Hospital - Albert Lea will host ... rallying against Mayo Clinic. Specifically, media can talk to steering committee members and patients ... close the Albert Lea hospital. , The rally aims to protect the most vulnerable ...
Breaking Medicine News(10 mins):
(Date:9/6/2017)... 2017 NeuroRx, a clinical stage biopharma company developing ... (ASIB), has been granted Fast Track status by the US ... (ketamine HCl) followed by NRX-101 (D-cycloserine + lurasidone). The company ... this sequential therapy targeting patients who are admitted to Emergency ... ...
(Date:9/5/2017)... 2017 Sapheneia and Scannerside received FDA 510(k) ... is a third-party Vendor neutral CT product that makes ... compliance with current MITA standards. ... solution is specifically designed to provide CT operators, prior ... doses over a predefined threshold. Scannerside Dose Check is ...
(Date:9/5/2017)... WAYNE, N.J. , Sept. 5, 2017 /PRNewswire/ ... technology, has created a vibrant charitable donation program ... funds and support congenital heart defect research by ... healthcare providers and the general public are encouraged ... and submit the completed artwork to the ...
Breaking Medicine Technology:
Cached News: