SAN ANTONIO, May 22 A commonly prescribed incontinence drug may help patients in more than one way, according to research completed by the University of Pittsburgh. When taken orally, trospium chloride not only helps control symptoms of overactive bladder systemically, but according to this study, it also may help control symptoms in the bladder itself when it comes into contact with the bladder walls. Results of this study are being presented today at the annual meeting of the American Urological Association (AUA) in San Antonio, and are published in abstract 542 in the AUA proceedings.
"When taken orally, certain classes of drugs can control the muscle contractions that cause conditions like overactive bladder. In this study, we have found one drug, trospium, reacts with the bladder muscle as urine is stored in the bladder," said Michael Chancellor, M.D., professor, department of urology, University of Pittsburgh School of Medicine. "It is exciting to see that this drug could be helping the same patients in more ways than we had previously thought."
In the study, urine samples from human subjects taking the anti-muscarinic drugs trospium, tolterodine LA and oxybutynin XL and from control subjects were instilled into the bladders of animal models.
Researchers induced bladder overactivity using carbachol. The trospium bladder did not react to the carbachol, indicating that the trospium had a topical effect on controlling the muscle contractions. In the control, tolterodine- and oxybutynin-treated bladders, the length of time between bladder contractions and the bladder's capacity were decreased representing overactive bladder-type conditions and indicating no topical effect.
Anti-muscarinic drugs block receptors in the bladder responsible for smooth muscle contractions; by easing the muscle contractions, the number of incontinence episodes are reduced and bladder capacity is increased. Common urologic conditions like overactive bladPage: 1 2 Related medicine news :1
. Commonly used drug offers promise for premature babies2
. Commonly used pain medications do not prevent Alzheimers disease3
. Common anesthetic may induce cell death, generation of Alzheimers-associated protein4
. Common blood pressure drug treats muscular dystrophy in mice5
. Common PTSD drug is no more effective than placebo6
. Common cold may be just a fingertip away due to environmental contamination7
. Commonwealth Fund commission says the US health care system needs thorough transformation8
. Commonly recommended sedative does not improve infant sleep9
. Common asthma inhaler causing deaths, researchers assert10
. Common painkillers associated with increased risk of first hospital admission for heart failure11
. Commonly used blood pressure medication prevents aortic aneurysm in mice with Marfan syndrome