HOME >> MEDICINE >> NEWS
Compound in dairy products targets diabetes

Fatty acids commonly found in dairy products have successfully treated diabetes in mice, according to a researcher at Penn State. The compounds, known as conjugated linoleic acids (CLA), have also shown promising results in human trials, signaling a new way of potentially treating the disease without synthetic drugs.

"The compounds are predominantly found in dairy products such as milk, cheese and meat, and are formed by bacteria in ruminants that take linoleic acids fatty acids from plants and convert them into conjugated linoleic acids, or CLA," says Jack Vanden Heuvel, professor of molecular toxicology in Penn State's College of Agricultural Sciences and co-director of Penn State's Center of Excellence in Nutrigenomics.

Researchers first became interested in CLA when it was shown to inhibit a variety of cancers such as breast, skin and colon in mice, and further research showed effects on circulating cholesterol and inflammation. These effects are the same as the newest generation of synthetic drugs used to treat diabetes in humans.

These synthetic drugs act by triggering a set of nuclear receptors called PPAR. In addition to being targets for a variety of clinically effective drugs, PPARs belong to a large family of proteins, and their biological purpose is to sense fatty acids and fatty acid metabolites within the cell, says Vanden Heuvel.

When the synthetic drugs interact with these protein receptors, it turns the receptor "on," making it an active form of the protein, which then interacts with DNA and regulates gene expression. This increases the enzymes that process fatty acids and also increases the tissues' sensitivity to insulin.

"We wondered if CLA was using the same mechanism, in which case it could be used as an anti-diabetes drug," Vanden Heuvel says.

To test the idea, he used CLA on mice prone to adult onset (Type-2) diabetes. Results indicated that the mice had an improvement in insulin action,
'"/>

Contact: Amitabh Avasthi
axa47@psu.edu
814-865-9481
Penn State
3-Aug-2006


Page: 1 2

Related medicine news :

1. Compounds in licorice root may help fight tooth decay
2. Compound from marine bacteria shows potential as multiple myeloma therapy
3. National Academy of Sciences Institute of Medicine report calls for more dairy foods at school
4. Doctors sue Safeway and other dairy retailers
5. Low-fat dairy foods may help reduce risk of type 2 diabetes
6. Low-fat dairy may lower risk of type 2 diabetes in men
7. In presence of fragrant cleaning products, air purifiers that emit ozone can dirty the air
8. Tobacco companies admit their products cause cancer, but not in those who sue them
9. Transfusion-free surgical program reduced use of blood products for all liver transplant patients
10. Marketing products as remedies can promote risky behavior
11. Childrens viewing time may increase requests for advertised products

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/19/2017)... , ... January 19, 2017 , ... ... and staff members in 2017 who are passionate about making a difference in ... 1994 and headquartered in Tampa, UMA, a nonprofit healthcare educational institution, has more ...
(Date:1/19/2017)... ... January 19, 2017 , ... Tribble Insurance Agency, a ... eastern Virginia region, is inaugurating a charity event to honor Chad Phillip Dermyer, a ... duty last year, Chad Phillip Dermyer and his fellow officers were conducting routine stops ...
(Date:1/19/2017)... ... 19, 2017 , ... Creative messages to prevent distracted driving ... Impact Teen Drivers and California Casualty. Entries from students aged 14-22 can be ... $15,000 will be awarded for the best peer-to-peer messages sharing solutions to reckless ...
(Date:1/19/2017)... ... January 19, 2017 , ... Connecticut Dermatology Group (CDG) is proud and excited ... compassionate dermatologist. Dr. Kim brings an extensive background in cutting-edge dermatology care and ... pleasure to welcome back Dr. Kim to the CDG team” said President and Managing ...
(Date:1/19/2017)... ... 19, 2017 , ... Infinity® Massage Chairs announced today that Dan Grover has ... marketing strategies. Grover comes with a total of 15 years experience in consumer goods ... Executive Vice President of Direct Sales at Traeger® Wood Pellet Grills. , Grover ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... The drug delivery technology market is projected ... 1,179.20 billion in 2016, at a CAGR of 7.2% ... diseases, increasing demand for biologics, technological advancements, and new ... this market. Whereas, self-administration & home care and rising ... opportunities for players operating in this market. On the ...
(Date:1/18/2017)... -- Aprima Medical Software, a leading provider of innovative ... revenue cycle management (RCM) solutions for medical practices, ... Healthcare Data Solutions (HDS) of Coral Cables, FL. ... full support for HDS,s customers, which include approximately ... states. Financial terms were not disclosed. ...
(Date:1/18/2017)... , Jan. 18, 2017  Adaptive Sound Technologies, Inc. ... a new partnership with Hyatt Place Nashville/Downtown to deliver ... ASTI LectroFan sleep therapy machines in over two hundred ... the most important parts of having a great stay ... manager of Hyatt Place Nashville/Downtown. "We,re pleased to be ...
Breaking Medicine Technology:
Cached News: