HOME >> MEDICINE >> NEWS
Compound in dairy products targets diabetes

Fatty acids commonly found in dairy products have successfully treated diabetes in mice, according to a researcher at Penn State. The compounds, known as conjugated linoleic acids (CLA), have also shown promising results in human trials, signaling a new way of potentially treating the disease without synthetic drugs.

"The compounds are predominantly found in dairy products such as milk, cheese and meat, and are formed by bacteria in ruminants that take linoleic acids fatty acids from plants and convert them into conjugated linoleic acids, or CLA," says Jack Vanden Heuvel, professor of molecular toxicology in Penn State's College of Agricultural Sciences and co-director of Penn State's Center of Excellence in Nutrigenomics.

Researchers first became interested in CLA when it was shown to inhibit a variety of cancers such as breast, skin and colon in mice, and further research showed effects on circulating cholesterol and inflammation. These effects are the same as the newest generation of synthetic drugs used to treat diabetes in humans.

These synthetic drugs act by triggering a set of nuclear receptors called PPAR. In addition to being targets for a variety of clinically effective drugs, PPARs belong to a large family of proteins, and their biological purpose is to sense fatty acids and fatty acid metabolites within the cell, says Vanden Heuvel.

When the synthetic drugs interact with these protein receptors, it turns the receptor "on," making it an active form of the protein, which then interacts with DNA and regulates gene expression. This increases the enzymes that process fatty acids and also increases the tissues' sensitivity to insulin.

"We wondered if CLA was using the same mechanism, in which case it could be used as an anti-diabetes drug," Vanden Heuvel says.

To test the idea, he used CLA on mice prone to adult onset (Type-2) diabetes. Results indicated that the mice had an improvement in insulin action,
'"/>

Contact: Amitabh Avasthi
axa47@psu.edu
814-865-9481
Penn State
3-Aug-2006


Page: 1 2

Related medicine news :

1. Compounds in licorice root may help fight tooth decay
2. Compound from marine bacteria shows potential as multiple myeloma therapy
3. National Academy of Sciences Institute of Medicine report calls for more dairy foods at school
4. Doctors sue Safeway and other dairy retailers
5. Low-fat dairy foods may help reduce risk of type 2 diabetes
6. Low-fat dairy may lower risk of type 2 diabetes in men
7. In presence of fragrant cleaning products, air purifiers that emit ozone can dirty the air
8. Tobacco companies admit their products cause cancer, but not in those who sue them
9. Transfusion-free surgical program reduced use of blood products for all liver transplant patients
10. Marketing products as remedies can promote risky behavior
11. Childrens viewing time may increase requests for advertised products

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Compound dairy products targets diabetes

(Date:7/31/2015)... ... 2015 , ... The Mount Sinai Health System will work with Columbia Care ... related, experimental treatments. The collaboration moves into the next phase with the recent decision ... five state licenses to produce and dispense medical marijuana. , Mount Sinai and ...
(Date:7/31/2015)... ... July 31, 2015 , ... Like nearly every other form of surgery, ... upgraded, made more effective and less intrusive and painful. Leading these advances in ... Dr. Loria currently stands as the only doctor in the United States who ...
(Date:7/31/2015)... AB (PRWEB) , ... July 31, 2015 , ... The ... "When patients don't experience angina until a heart rate of 150 beats versus 100 ... Clinic in Calgary. "We are able to give life back to patients with heart ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... ... recently published a blog post that encourages the understanding and treatment of ankle ... people opt for in-home remedies. This can be dangerous if the condition augments ...
(Date:7/31/2015)... ... July 31, 2015 , ... Awarded to only the Top 10 ... announce that they are the latest recipients of the Center of Clinical Excellence ... of the worldwide leaders in the science of hair transplant. , Parsa Mohebi Hair ...
Breaking Medicine News(10 mins):Health News:Mount Sinai to Collaborate with Columbia Care on Medical Marijuana Research 2Health News:Mount Sinai to Collaborate with Columbia Care on Medical Marijuana Research 3Health News:Loria Medical Penile Enlargement Center to Expand, Offering Practice Partnership to Doctors 2Health News:Heart Fit Clinic Helps Patient Increase Fitness Level with External Counterpulsation 2Health News:Absolute PhysioCare & Sports Rehab Promotes Understanding & Treatment of Ankle Sprains 2Health News:Prestigious Medical Award Given To Parsa Mohebi Hair Restoration for Excellence in Hair Transplantation 2
(Date:7/31/2015)... HILL, N.C. , July 31, 2015  In ... of customers who are increasingly mobile, increasingly connected, and ... a growing variety of customer interaction channels and tools ... technology, including social media. According to ... the over the counter (OTC) segment in a call ...
(Date:7/31/2015)... , July 31, 2015 The ... press release on July 28, 2015, "Surviving Your ... Launches Fundraising for Patient Safety." A ... sentence should read: "PPAHS is a ... Patients on Opioids. For more information on the National ...
(Date:7/31/2015)... Pa. , July 31, 2015 ... fully integrated specialty pharmaceutical company focused on developing, ... the closing of its previously announced underwritten public ... at a public offering price of $11.25 per ... offering included 1,000,000 shares issued upon the exercise ...
Breaking Medicine Technology:Best Practices in Building World-Class Consumer & Over-the-Counter Call Centers 2Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 2Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 3Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 4
Cached News: