HOME >> MEDICINE >> NEWS
Compound in dairy products targets diabetes

Fatty acids commonly found in dairy products have successfully treated diabetes in mice, according to a researcher at Penn State. The compounds, known as conjugated linoleic acids (CLA), have also shown promising results in human trials, signaling a new way of potentially treating the disease without synthetic drugs.

"The compounds are predominantly found in dairy products such as milk, cheese and meat, and are formed by bacteria in ruminants that take linoleic acids fatty acids from plants and convert them into conjugated linoleic acids, or CLA," says Jack Vanden Heuvel, professor of molecular toxicology in Penn State's College of Agricultural Sciences and co-director of Penn State's Center of Excellence in Nutrigenomics.

Researchers first became interested in CLA when it was shown to inhibit a variety of cancers such as breast, skin and colon in mice, and further research showed effects on circulating cholesterol and inflammation. These effects are the same as the newest generation of synthetic drugs used to treat diabetes in humans.

These synthetic drugs act by triggering a set of nuclear receptors called PPAR. In addition to being targets for a variety of clinically effective drugs, PPARs belong to a large family of proteins, and their biological purpose is to sense fatty acids and fatty acid metabolites within the cell, says Vanden Heuvel.

When the synthetic drugs interact with these protein receptors, it turns the receptor "on," making it an active form of the protein, which then interacts with DNA and regulates gene expression. This increases the enzymes that process fatty acids and also increases the tissues' sensitivity to insulin.

"We wondered if CLA was using the same mechanism, in which case it could be used as an anti-diabetes drug," Vanden Heuvel says.

To test the idea, he used CLA on mice prone to adult onset (Type-2) diabetes. Results indicated that the mice had an improvement in insulin action,
'"/>

Contact: Amitabh Avasthi
axa47@psu.edu
814-865-9481
Penn State
3-Aug-2006


Page: 1 2

Related medicine news :

1. Compounds in licorice root may help fight tooth decay
2. Compound from marine bacteria shows potential as multiple myeloma therapy
3. National Academy of Sciences Institute of Medicine report calls for more dairy foods at school
4. Doctors sue Safeway and other dairy retailers
5. Low-fat dairy foods may help reduce risk of type 2 diabetes
6. Low-fat dairy may lower risk of type 2 diabetes in men
7. In presence of fragrant cleaning products, air purifiers that emit ozone can dirty the air
8. Tobacco companies admit their products cause cancer, but not in those who sue them
9. Transfusion-free surgical program reduced use of blood products for all liver transplant patients
10. Marketing products as remedies can promote risky behavior
11. Childrens viewing time may increase requests for advertised products

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Compound dairy products targets diabetes

(Date:3/6/2015)... (PRWEB) March 06, 2015 Follow ... of the most common forms of cancer and is ... cancer can be screened through various techniques and tools, ... however remains the gold standard technique in breast cancer ... cost, time taken for the procedure, required expertise to ...
(Date:3/6/2015)... 2015 Ticket Down is a reputable source ... exchange has extended their customer appreciation discount code ED-SHEERAN-2015 for ... Yorkshire England and he began his career in the music ... couple of years Ed Sheeran has become a household name. ... on stage he is having the time of his life ...
(Date:3/6/2015)... Further solidifying their position as a ... announced today that the company has earned Inavero’s Best ... of Staffing Talent Award five years in a row. ... Talent Diamond winners are proven industry leaders in service ... the individuals they have helped find temporary and permanent ...
(Date:3/6/2015)... Since Medicare began paying for chronic ... been an overwhelming demand from providers for straightforward guidance ... program. The Centers for Medicare & Medicaid Services ... PYA’s updated white paper—“ Providing and Billing Medicare for ... detailed, yet practical “how to” manual for providers looking ...
(Date:3/6/2015)... Magellan Rx Management’s 2014 Medical Pharmacy Trend Report ... and statistics on one of the nation’s biggest drivers ... Management will discuss key findings from the report in ... Spend,” a complimentary March 19 webinar, managed and moderated ... makes up more than a quarter of total drug ...
Breaking Medicine News(10 mins):Health News:Rising Popularity of 3D Mammography Drives the Global Mammography Equipment Market, According to a New Report by Global Industry Analysts, Inc. 2Health News:Rising Popularity of 3D Mammography Drives the Global Mammography Equipment Market, According to a New Report by Global Industry Analysts, Inc. 3Health News:Ed Sheeran Tickets in Indianapolis, Austin, Albany, St. Louis, London, Des Moines, Salt Lake City, Saskatoon, Regina and Denver/Morrison Now On Sale at Ticket Down 2Health News:Cross Country Healthcare: Medical Doctor Associates Earns Inavero's 2015 Best of Staffing Talent Diamond Award 2Health News:Cross Country Healthcare: Medical Doctor Associates Earns Inavero's 2015 Best of Staffing Talent Diamond Award 3Health News:Updated PYA White Paper Meets Demand for Guidance on Providing and Billing Medicare for Chronic Care Management 2Health News:Atlantic Information Services, Magellan Rx Management Partner on Complimentary Webinar Outlining Key Findings of New Medical Pharmacy Trend Report 2
(Date:3/5/2015)... SAN DIEGO , March 5, 2015 /PRNewswire/ ... company engaged in the development of biosimilar therapeutics ... announced today that its fourth quarter and full ... Monday, March 16, 2015, before the market opens ... management will host a conference call to discuss ...
(Date:3/5/2015)... 5, 2015  IRIDEX Corporation (Nasdaq: IRIX ) ... ended January 3, 2015.  , Revenues were $11.8 ... the Company and up 11% from $10.6 million in the ... a record, up 12% from $38.3 million in 2013. ... up from 48.6% in the fourth quarter of the prior ...
(Date:3/5/2015)... NEW YORK , March 5, 2015 /PRNewswire/ ... evolving set of regulations, Ethics & Compliance professionals ... according to a new survey issued today by ... services and education. An overwhelming majority of respondents ... far the most important component of E&C training ...
Breaking Medicine Technology:Pfenex To Report Fourth Quarter and Full Year 2014 Results and Provide Business Update 2IRIDEX Reports 2014 Fourth Quarter, Year-End Results 2IRIDEX Reports 2014 Fourth Quarter, Year-End Results 3IRIDEX Reports 2014 Fourth Quarter, Year-End Results 4IRIDEX Reports 2014 Fourth Quarter, Year-End Results 5IRIDEX Reports 2014 Fourth Quarter, Year-End Results 6IRIDEX Reports 2014 Fourth Quarter, Year-End Results 7IRIDEX Reports 2014 Fourth Quarter, Year-End Results 8Pharmaceutical Ethics & Compliance Professionals Place Company Values Front and Center 2Pharmaceutical Ethics & Compliance Professionals Place Company Values Front and Center 3
Cached News: