HOME >> MEDICINE >> NEWS
Compound in dairy products targets diabetes

Fatty acids commonly found in dairy products have successfully treated diabetes in mice, according to a researcher at Penn State. The compounds, known as conjugated linoleic acids (CLA), have also shown promising results in human trials, signaling a new way of potentially treating the disease without synthetic drugs.

"The compounds are predominantly found in dairy products such as milk, cheese and meat, and are formed by bacteria in ruminants that take linoleic acids fatty acids from plants and convert them into conjugated linoleic acids, or CLA," says Jack Vanden Heuvel, professor of molecular toxicology in Penn State's College of Agricultural Sciences and co-director of Penn State's Center of Excellence in Nutrigenomics.

Researchers first became interested in CLA when it was shown to inhibit a variety of cancers such as breast, skin and colon in mice, and further research showed effects on circulating cholesterol and inflammation. These effects are the same as the newest generation of synthetic drugs used to treat diabetes in humans.

These synthetic drugs act by triggering a set of nuclear receptors called PPAR. In addition to being targets for a variety of clinically effective drugs, PPARs belong to a large family of proteins, and their biological purpose is to sense fatty acids and fatty acid metabolites within the cell, says Vanden Heuvel.

When the synthetic drugs interact with these protein receptors, it turns the receptor "on," making it an active form of the protein, which then interacts with DNA and regulates gene expression. This increases the enzymes that process fatty acids and also increases the tissues' sensitivity to insulin.

"We wondered if CLA was using the same mechanism, in which case it could be used as an anti-diabetes drug," Vanden Heuvel says.

To test the idea, he used CLA on mice prone to adult onset (Type-2) diabetes. Results indicated that the mice had an improvement in insulin action,
'"/>

Contact: Amitabh Avasthi
axa47@psu.edu
814-865-9481
Penn State
3-Aug-2006


Page: 1 2

Related medicine news :

1. Compounds in licorice root may help fight tooth decay
2. Compound from marine bacteria shows potential as multiple myeloma therapy
3. National Academy of Sciences Institute of Medicine report calls for more dairy foods at school
4. Doctors sue Safeway and other dairy retailers
5. Low-fat dairy foods may help reduce risk of type 2 diabetes
6. Low-fat dairy may lower risk of type 2 diabetes in men
7. In presence of fragrant cleaning products, air purifiers that emit ozone can dirty the air
8. Tobacco companies admit their products cause cancer, but not in those who sue them
9. Transfusion-free surgical program reduced use of blood products for all liver transplant patients
10. Marketing products as remedies can promote risky behavior
11. Childrens viewing time may increase requests for advertised products

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/23/2017)... ... May 23, 2017 , ... The Gallery of ... Sadati, is pleased to announce a new treatment option called Vivace Microneedling. This ... face, neck, and body through a virtually pain-free, non-surgical treatment. Vivace Microneedling combines ...
(Date:5/23/2017)... ... May 23, 2017 , ... Drs. Allen ... peri-implantitis in Las Vegas, NV, and the importance of treating it ... consultation and leading care for peri-implantitis, with or without a referral. As experienced ...
(Date:5/23/2017)... Indianapolis, IN (PRWEB) , ... May 23, 2017 ... ... announced the availability of video chat as a standard feature on its secure ... style from text to voice to video depending on the type and urgency ...
(Date:5/23/2017)... (PRWEB) , ... May 23, 2017 , ... Orbita’s Nathan ... Tuesday, May 23, 2017 in San Francisco. Titled Connected Health and IoT: Technology ... Home Event hosted by Parks Associates, a market research and consulting firm specializing ...
(Date:5/23/2017)... CA (PRWEB) , ... May 23, 2017 , ... ... can now receive treatment using the SPEED System™ Orthodontics, with or without a ... orthodontist in El Segundo, CA, who is skilled in providing patients ...
Breaking Medicine News(10 mins):
(Date:5/4/2017)... CAESAREA, Israel , May 4, 2017  DarioHealth ... with mobile health and big data solutions, today announced ... an A&D Company, and STI Technologies Limited to lower ... effective immediately. Through STI,s innoviCares card, which is available ... , DarioHealth customers will be eligible for additional ...
(Date:5/4/2017)... May 4, 2017   BioLife Solutions , Inc. ... and marketer of proprietary clinical grade hypothermic storage ... the "Company"), today announced that the Company,s first quarter ... on Thursday, May 11, 2017, and that the Company ... 1:30 p.m. PT that afternoon. Management will provide an ...
(Date:5/3/2017)... Md. , May 3, 2017  Kalorama ... growth of nine percent next year and this ... organ and hematopoietic stem cell (HSCT) or bone ... donor. Molecular testing technologies are well-suited for this task. ... market research publisher Kalorama Information. The various PCR-based ...
Breaking Medicine Technology:
Cached News: