HOME >> MEDICINE >> NEWS
Compound in dairy products targets diabetes

Fatty acids commonly found in dairy products have successfully treated diabetes in mice, according to a researcher at Penn State. The compounds, known as conjugated linoleic acids (CLA), have also shown promising results in human trials, signaling a new way of potentially treating the disease without synthetic drugs.

"The compounds are predominantly found in dairy products such as milk, cheese and meat, and are formed by bacteria in ruminants that take linoleic acids fatty acids from plants and convert them into conjugated linoleic acids, or CLA," says Jack Vanden Heuvel, professor of molecular toxicology in Penn State's College of Agricultural Sciences and co-director of Penn State's Center of Excellence in Nutrigenomics.

Researchers first became interested in CLA when it was shown to inhibit a variety of cancers such as breast, skin and colon in mice, and further research showed effects on circulating cholesterol and inflammation. These effects are the same as the newest generation of synthetic drugs used to treat diabetes in humans.

These synthetic drugs act by triggering a set of nuclear receptors called PPAR. In addition to being targets for a variety of clinically effective drugs, PPARs belong to a large family of proteins, and their biological purpose is to sense fatty acids and fatty acid metabolites within the cell, says Vanden Heuvel.

When the synthetic drugs interact with these protein receptors, it turns the receptor "on," making it an active form of the protein, which then interacts with DNA and regulates gene expression. This increases the enzymes that process fatty acids and also increases the tissues' sensitivity to insulin.

"We wondered if CLA was using the same mechanism, in which case it could be used as an anti-diabetes drug," Vanden Heuvel says.

To test the idea, he used CLA on mice prone to adult onset (Type-2) diabetes. Results indicated that the mice had an improvement in insulin action,
'"/>

Contact: Amitabh Avasthi
axa47@psu.edu
814-865-9481
Penn State
3-Aug-2006


Page: 1 2

Related medicine news :

1. Compounds in licorice root may help fight tooth decay
2. Compound from marine bacteria shows potential as multiple myeloma therapy
3. National Academy of Sciences Institute of Medicine report calls for more dairy foods at school
4. Doctors sue Safeway and other dairy retailers
5. Low-fat dairy foods may help reduce risk of type 2 diabetes
6. Low-fat dairy may lower risk of type 2 diabetes in men
7. In presence of fragrant cleaning products, air purifiers that emit ozone can dirty the air
8. Tobacco companies admit their products cause cancer, but not in those who sue them
9. Transfusion-free surgical program reduced use of blood products for all liver transplant patients
10. Marketing products as remedies can promote risky behavior
11. Childrens viewing time may increase requests for advertised products

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... ... March 28, 2017 , ... Calibration, qualification, ... ensuring high-quality results and maintaining GMP and USP compliance. In a new webinar ... with GMP requirements " these requirements are explained. The challenge is to ...
(Date:3/28/2017)... ... March 28, 2017 , ... Neurotechnology , ... biometric time and attendance tracking products: the new NCheck Cloud Bio Attendance cloud-based ... Attendance uses biometric face recognition to enable users to check in and out ...
(Date:3/28/2017)... WI (PRWEB) , ... March 28, 2017 , ... ... self-funded health plans work, the Self-Funding Success website has recently developed and published ... Self-Funded Health Plans ” was created based on common inquiries the site’s team ...
(Date:3/28/2017)... ... ... A minimally invasive porcelain veneer is increasing in popularity ... Dental Laboratories (NADL) is informing dentists about the benefits of minimally invasive dentistry, ... and technicians that create these veneers. , According to National Board for ...
(Date:3/28/2017)... ... March 28, 2017 , ... Public relations pros work hard to earn placements ... channels. , While many results are clear, much of PR is hard to quantify. ... it comes to measurement, firms should always take an all-inclusive approach that takes both ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... and TORONTO , March ... leading full service medical device development firm, ... the visionary Toronto -based medical device ... will better serve medtech companies throughout North ... resources and experienced medical device talent spanning the design, ...
(Date:3/28/2017)... , United Kingdom and  BOSTON , March ... provider Linguamatics today announced a partnership ... . The agreement allows pharmaceutical companies to extract ... I2E text mining technology. ... 18 of the top 20 global pharmaceutical companies. ...
(Date:3/28/2017)... AVIV, Israel , March 28, 2017 ... . This new business entity, Emosis Ltd, headquartered in ... development of novel assays complementing the mother company existing technology platform ... commercialization and sales development of Emosis kits. ... This strategic move starts building Emosis international ...
Breaking Medicine Technology:
Cached News: