HOME >> MEDICINE >> NEWS
Contrast agent puts new light on diagnosing breast cancer

ast tissue, making it harder to distinguish between healthy tissue and questionable masses in mammograms, Frangioni says.

The new agent works by binding to micro-calcifications produced in breast cancers. Though scientists cant explain exactly why these calcifications occur, studies show that the calcifications in malignant breast tumors contain a higher proportion of a particular calcium salt called hydroxyapatite. In benign tumors, the predominant calcium salt is calcium oxalate.

By homing in on hydroxyapatite, we can target these malignant cells with a high degree of specificity, and that has the potential to improve the patients outcome, Frangioni says.

The contrast agents are designed using a combination of bisphosphonate, a type of drug used to strengthen bone, with a near-infrared fluorophore. When used with optical tomography, an imaging method that transmits near-infrared light through the body, doctors can reconstruct a three-dimensional image of tissues deep inside the breast, highlighting areas where malignant tumors appear.

The agent also may be used during surgery to pinpoint the location of hydroxyapatite, and therefore the breast cancer cells themselves, Frangioni notes.

His group began working to develop agents to target hydroxyapatite six years ago, but efforts were stalled by the inability to manufacture large quantities of the agent.

It was a chemical catch22, he says. Bisphosphonates are insoluble in anything but water, but to prepare large quantities of the substance for our studies, we need to perform the reaction in the absence of water.

Last year, Frangionis chemistry group, led by Bhushan, went back to the drawing board and devised a scheme that allowed them to synthesize the agents sans water. Once the compound was completely assembled, the researchers found a way to then make it water soluble.

Recent studies by the lab proved that the new agent works well in
'"/>


26-Mar-2007


Page: 1 2 3

Related medicine news :

1. Shark cartilage shows no benefit as a therapeutic agent for lung cancer
2. Targeted, oral agent Enzastaurin shows favorable results
3. Studies suggest investigational agent reduces disease activity in MS
4. Novel anti-oxidant and anti-inflammatory agent shows effectiveness on key endpoints in trial
5. MRI contrast agent can detect heart attack in the making
6. New reagent delivers a chemical breakthrough at FSU
7. High-resolution imaging with contrast agent shows promise in osteoarthritis research
8. Study suggests anesthetic agent may have rapid antidepressant effects
9. Alzheimers medication shows promise in treating nerve agent and pesticide poisoning
10. Cranberries contain possible anti-caries/anti-plaque agents
11. New contrast agents may be on horizon for better medical imaging

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Contrast agent puts new light diagnosing breast cancer

(Date:11/27/2014)... Providenciales, Turks and Caicos Islands; BWI (PRWEB) November 28, ... earlier for the Tuscany Resort in the Turks & ... 44 resorts by TripAdvisor in Providenciales, is announcing a ... oceanfront three bedroom villa rentals. And they are ... the resort. , Additionally, The Tuscany, is having ...
(Date:11/27/2014)... 28, 2014 Let the Black Friday sales ... with bows on top, filled with skincare goodies, will delight ... discounted today while quantities last - no coupon required. ... are also available on Amazon at the same sales prices. ... shop product page for ease. , The company published a ...
(Date:11/27/2014)... (PRWEB) November 27, 2014 According to ... those companies looking to break into the surgical ... medical specialties, other than the MIS field dominated by ... of the U.S. surgical robotics market by 2020. ... explains Dr. Kamran Zamanian, CEO and President of iData. ...
(Date:11/27/2014)... Cambrionix Ltd today announced that it ranked number ... of the 50 fastest-growing technology companies in the UK. ... five years. Cambrionix Ltd grew 2989 percent during this ... region of Cambridgeshire and East and first in the sector ... is recognition of the hard work put in by our ...
(Date:11/27/2014)... Blood-borne pathogens raise the risk of spreading ... in place to counter this. However, it doesn’t seem ... with menstrual blood are taken as seriously. , ... way to handle tampons and menstrual pads while also ... , He then created a prototype of the Sani-M, ...
Breaking Medicine News(10 mins):Health News:The Tuscany on Grace Bay, Top-Rated TripAdvisor Resort in the Turks & Caicos Islands, Offers Special Pre-Christmas & January 2015 Promotions! 2Health News:Big Christmas Sales Begin Today at Sublime Beauty® for all Christmas Gift Selections and Skincare Sets 2Health News:U.S. Robotic Surgery Market Set to Diversify and Grow: Intuitive Surgical’s ‘da Vinci’ Robot Revenues to Increasingly Rely On Procedures and Services 2Health News:Cambrionix Ltd Ranks Top 10 in the Deloitte UK Technology Fast 50 2Health News:Cambrionix Ltd Ranks Top 10 in the Deloitte UK Technology Fast 50 3Health News:Cambrionix Ltd Ranks Top 10 in the Deloitte UK Technology Fast 50 4
(Date:11/26/2014)... JOSE, Calif. , Nov. 26, 2014 /PRNewswire/ ... technologies to produce novel therapies for infectious diseases, ... , M.D., an internationally recognized key opinion leader ... the Company,s scientific advisory board. Founder ... Ph.D., stated, "We believe Dr. Opal,s extensive experience ...
(Date:11/26/2014)... 2014 According to the ... Source (Electric, Battery, Pneumatic), by Product (Drill, Saw, ... by Application (Orthopedic, ENT, Oral, Thoracic, Neurology) - ... Powered Surgical Instruments Market is estimated to be ... and is expected to grow at a moderate ...
(Date:11/26/2014)... Reinforcing its commitment to enabling confident diagnosis ... PHG AEX: PHIA) today announced 510(k) clearance from ... IQon Spectral CT , presenting an entirely new ... a new dimension to Computed Tomography (CT) imaging, delivering ... based on their material content within a single scan. ...
Breaking Medicine Technology:Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 2Aridis Pharmaceuticals Appoints Dr. Steven Opal to Scientific Advisory Board 3Powered Surgical Instruments Market Worth $2.1 Billion by 2019 2Powered Surgical Instruments Market Worth $2.1 Billion by 2019 3Powered Surgical Instruments Market Worth $2.1 Billion by 2019 4Philips receives FDA 510(k) clearance for IQon Spectral CT 2Philips receives FDA 510(k) clearance for IQon Spectral CT 3
Cached News: