HOME >> MEDICINE >> NEWS
DNA repair in mammal embryos is a matter of timing

taxia telangiectasia. This new work points to the specific DNA repair pathway that ATM is required to monitor in order to prevent neurodegeneration.

The HR pathway fixes a broken chromosome by using that chromosome's exact "twin" as a blueprint to guide the repair job, according to Peter McKinnon, Ph.D., an associate member of Genetics and Tumor Cell Biology at St. Jude and senior author of the PNAS paper. However, such twins only exist in cells that are preparing to divide into two new cells, a process called mitosis, he noted. Then, as the cell starts to divide, each member of the sister chromatid pair moves into a different new cell.

Because HR is active only during the first half of embryo development, it is the critical repair pathway for the rapidly multiplying precursor and stem cells--cells that populate the body during early development with "daughter" cells--that later take on specific roles, according to researchers.

"Therefore, if HR-related apoptosis is blocked during the early part of embryo development, precursor and stem cells are affected. And since those cells give rise to many different types of cells and tissues, many different types of cancers can arise, such as skin cancer and sarcomas (cancers of bone, cartilage, fat, muscle or blood vessels)," McKinnon said.

But as cells acquire specialized structures and functions, they stop dividing and no longer produce sister chromatids. "When cells begin assuming specific roles in the brain, they stow away most of their chromosomes into tightly wrapped strings of DNA and use only those genes required to survive and allow them to perform these roles," McKinnon explained. "In the absence of sister chromatids to use as blueprints, the NHEJ repair pathway uses various chemical means to join the broken ends of DNA strands."

Since the cell uses NHEJ only when many cells are becoming specialized, cancers that arise in the absence of this pathway are more specific, suc
'"/>

Contact: Bonnie Kourvelas
media@stjude.org
901-495-3306
St. Jude Children's Research Hospital
19-Jun-2006


Page: 1 2 3

Related medicine news :

1. UD scientists invent novel hydrogels for repairing, regenerating human tissue
2. Nerves controlling muscles are best repaired with similar nerves
3. New biotech company to commercialize novel UD gene-repair technology
4. UW launches study testing adult stem cells for heart damage repair
5. First Quantum Grant to fund stem cell repair of damage from stroke
6. Drug can quickly mobilize an army of cells to repair injury
7. Man emerges from 19 years in minimally conscious state as brain repairs itself
8. Hopkins scientists use embryonic stem cells, new cues to awaken latent motor nerve repair
9. Novel stem cell technology leads to better spinal cord repair
10. Delayed aortic trauma repair may improve survival
11. Placental growth factor may help body repair heart attack damage

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: DNA repair mammal embryos matter timing

(Date:3/30/2015)... AlignLife of Dundee, Fl owned and managed by ... As part of a national wellness franchise, AlignLife brings ... for all ages to address numerous health conditions. The ... compassion of the doctors serving the local communities. AlignLife ... extensive training system in order to join the AlignLife ...
(Date:3/30/2015)... March 31, 2015 Thomas Peither ... most respected inspection readiness professionals — will conduct ... through the inspection process. , Attendees will learn ... investigator and what they look for when conducting ... exercises and roundtable discussions. This will assure attendees ...
(Date:3/30/2015)... 2015 NAPW honors ... Hands Warm Hearts, as a 2015 Professional Woman of ... for leadership in home health services. As the largest, ... every industry and profession, the National Association of Professional ... nearly 700,000 members and over 200 Local Chapters. , ...
(Date:3/30/2015)... CA (PRWEB) March 30, 2015 Foundations ... proud to announce the start of its 41st national ... author Jane McGonigal, and former Congressman Patrick J. Kennedy ... Conference being held in San Diego, CA, March ... Coronado. The national conference brings together leading experts specializing ...
(Date:3/30/2015)... With the summer dry season approaching, residents ... to make sure they have enough water. Fresh water ... that when Earth loses water and becomes dehydrated, the ... Kleyne calls this “body drought” and suggests several ways ... body drought and dehydration on her Sharon Kleyne Hour™ ...
Breaking Medicine News(10 mins):Health News:FDAnews Announces — GMP Inspections in Europe: Proven Strategies on How to Prepare Investigations, June 10-11, 2015, Frankfurt, Germany 2Health News:FDAnews Announces — GMP Inspections in Europe: Proven Strategies on How to Prepare Investigations, June 10-11, 2015, Frankfurt, Germany 3Health News:FDAnews Announces — GMP Inspections in Europe: Proven Strategies on How to Prepare Investigations, June 10-11, 2015, Frankfurt, Germany 4Health News:National Association of Professional Women Announces Rachel L. Gregus, Manager / Co-Founder of Safe Hands Warm Hearts, a 2015 Professional Woman of the Year 2Health News:Foundations Recovery Network Kicks Off Its 41st National Conference Specializing in the Treatment of Substance Abuse and Behavioral Health 2Health News:As California Dry Season Approaches, Risk of Body Drought Increases, Warns Fresh Water Advocate 2Health News:As California Dry Season Approaches, Risk of Body Drought Increases, Warns Fresh Water Advocate 3
(Date:3/30/2015)... OAKS, Calif. , March 30, 2015  Amgen (NASDAQ: ... Debates in Biosimilars conference at 9:05 a.m. ET on Thursday, ... New York City . Scott Foraker ... will present at the conference. Live audio of the presentation ... www.amgen.com , under Investors. A replay of the webcast ...
(Date:3/30/2015)... , March 30, 2015  EP Global ... to shareholders, EPGL has opened negotiations with CooperVision, ... to License their new ophthalmic technologies. As previously ... Inc. have co-developed new contact lens technologies, which ... is estimated by some industry experts that just ...
(Date:3/30/2015)... -- The investigational S- equol nutritional supplement may be ... as hot flashes, according to a new peer-reviewed article ... "Current data suggest that women may have ... and possibly additional benefits, such as skin health. Given ... and health care professionals may consider the use of ...
Breaking Medicine Technology:Amgen To Present At The Goldman Sachs Key Debates In Biosimilars Conference 2CooperVision, Inc. Seeks Intermediary as EP Global Communications, Inc., Opens Negotiations at $1.1B 2CooperVision, Inc. Seeks Intermediary as EP Global Communications, Inc., Opens Negotiations at $1.1B 3New Scientific Review Suggests Some Women May Benefit from Considering Use of S-equol to Ease Menopause Symptoms 2New Scientific Review Suggests Some Women May Benefit from Considering Use of S-equol to Ease Menopause Symptoms 3New Scientific Review Suggests Some Women May Benefit from Considering Use of S-equol to Ease Menopause Symptoms 4New Scientific Review Suggests Some Women May Benefit from Considering Use of S-equol to Ease Menopause Symptoms 5New Scientific Review Suggests Some Women May Benefit from Considering Use of S-equol to Ease Menopause Symptoms 6
Cached News: