HOME >> MEDICINE >> NEWS
DNA vaccine against multiple sclerosis appears safe, potentially beneficial

A newly developed DNA vaccine appears safe and may produce beneficial changes in the brains and immune systems of individuals with multiple sclerosis, according to an article posted online today that will appear in the October 2007 print issue of Archives of Neurology, one of the JAMA/Archives journals.

In patients with multiple sclerosis (MS), the immune system attacks the myelin sheaths that protect nerve cells in the brain and spinal cord, according to background information in the article. The nerve cells axon, which transmits messages to other neurons, is eventually destroyed. The cause of MS is unknown, but evidence points to the involvement of immune cells and antibodies that recognize and attack specific substances in the myelin, such as myelin basic protein. Certain cytokines, small proteins produced by cells that trigger inflammation, also may play a role.

Amit Bar-Or, M.D., of the Montreal Neurological Institute and colleagues tested a DNA vaccine, BHT-3009, that encodes a full-length human myelin basic protein. Between 2004 and 2006, the researchers administered the vaccine to 30 patients with relapsing-remitting MS [characterized by symptomatic periods and periods of remission] or secondary progressive MS [when symptoms progressively worsen, but there still may be periods of remission]. After one, three, five and nine weeks, participants received intramuscular injections of placebo or BHT-3009 (in doses of .5 milligrams, 1.5 milligrams or 3 milligrams), with or without 80-milligram pills of atorvastatin calcium, a lipid-lowering drug previously shown to be effective in autoimmune conditions. After 13 weeks, participants who initially received placebo received four injections of BHT-3009.

Magnetic resonance imaging (MRI) and other safety evaluations were performed at the beginning of the study, and again after five, nine, 13, 26, 38 and 50 weeks. BHT-3009 was safe and well tolerated, provided favorable trends on brain MRI
'"/>

Contact: Susan Thomas
415-352-6262
JAMA and Archives Journals
13-Aug-2007


Page: 1 2

Related medicine news :

1. Traditional Chinese exercises may increase efficacy of flu vaccine
2. Study reveals gaps in vaccine financing for underinsured children
3. Trials underway for essential new TB vaccine
4. Hib vaccine: A critical ally in Asias effort to reduce child deaths
5. Progress toward an antitumor vaccine
6. Chemotherapy may enhance the effectiveness of brain tumor vaccines
7. OHSU Cancer Institute shows findings of immunotherapy vaccine in prostate cancer patients
8. International studies show high efficacy for HPV vaccine
9. Vaxfectin-formulated measles DNA vaccine elicits long-term protection in nonhuman primates
10. Papillomavirus vaccine could substantially reduce cervical cancer incidence
11. Data on new vaccine for prostate cancer to be presented

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/2/2016)... ... May 02, 2016 , ... This week Omega Institute, a ... guest season which runs through October. Omega is offering a record 370 in-person workshops ... “There has never been such widespread interest in or need for the knowledge and ...
(Date:5/2/2016)... ... May 02, 2016 , ... Dr. Rassouli, dentist in Orange County, CA ... to the research, which was published in the “Journal of the American Geriatrics Society,” ... 5.4 million Americans have Alzheimer’s disease. The study found that dental problems may increase ...
(Date:5/2/2016)... , ... May 02, 2016 ... ... report that many commonly used prescription medications, including anxiolytics, painkillers, antidepressants and ... these risks, Novus Medical Detox Center —a leading Florida-based drug treatment ...
(Date:5/2/2016)... (PRWEB) , ... May 02, 2016 , ... ... Centers (AAC) event, will be held at the Bellagio Hotel in Las Vegas, ... of Social Work (NASW) will be co-hosting the event. , This year’s conference ...
(Date:5/2/2016)... ... 02, 2016 , ... Consultative health care market research firm ... and Duane Reed, VP of business development of AJMC Strategic Solutions, will be ... (PBIRG) General Meeting from May 15-17 at the Boca Raton Resort & ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)... Mass. , May 2, 2016  While nearly ... that osteoporosis can have on their health, only about ...   according to the results of a new survey ... To mark the start of National Osteoporosis Month, Hologic ... health, which affects nearly 56 million Americans. ...
(Date:4/29/2016)... , April 29, 2016 ... Review, H1 2016" market research report that provides ... with comparative analysis at various stages, therapeutics assessment ... of administration (RoA) and molecule type, along with ... It also reviews key players involved in the ...
(Date:4/29/2016)... India , April 29, 2016 ... the life science laboratory due to the growing demands ... by advance technology, contemporary automated systems are already adept ... performed by slow, tedious and manual labor. Instrumentation continues ... were not even conceivable just a few years ago. ...
Breaking Medicine Technology:
Cached News: