HOME >> MEDICINE >> NEWS
DNA vaccine against multiple sclerosis appears safe, potentially beneficial

A newly developed DNA vaccine appears safe and may produce beneficial changes in the brains and immune systems of individuals with multiple sclerosis, according to an article posted online today that will appear in the October 2007 print issue of Archives of Neurology, one of the JAMA/Archives journals.

In patients with multiple sclerosis (MS), the immune system attacks the myelin sheaths that protect nerve cells in the brain and spinal cord, according to background information in the article. The nerve cells axon, which transmits messages to other neurons, is eventually destroyed. The cause of MS is unknown, but evidence points to the involvement of immune cells and antibodies that recognize and attack specific substances in the myelin, such as myelin basic protein. Certain cytokines, small proteins produced by cells that trigger inflammation, also may play a role.

Amit Bar-Or, M.D., of the Montreal Neurological Institute and colleagues tested a DNA vaccine, BHT-3009, that encodes a full-length human myelin basic protein. Between 2004 and 2006, the researchers administered the vaccine to 30 patients with relapsing-remitting MS [characterized by symptomatic periods and periods of remission] or secondary progressive MS [when symptoms progressively worsen, but there still may be periods of remission]. After one, three, five and nine weeks, participants received intramuscular injections of placebo or BHT-3009 (in doses of .5 milligrams, 1.5 milligrams or 3 milligrams), with or without 80-milligram pills of atorvastatin calcium, a lipid-lowering drug previously shown to be effective in autoimmune conditions. After 13 weeks, participants who initially received placebo received four injections of BHT-3009.

Magnetic resonance imaging (MRI) and other safety evaluations were performed at the beginning of the study, and again after five, nine, 13, 26, 38 and 50 weeks. BHT-3009 was safe and well tolerated, provided favorable trends on brain MRI
'"/>

Contact: Susan Thomas
415-352-6262
JAMA and Archives Journals
13-Aug-2007


Page: 1 2

Related medicine news :

1. Traditional Chinese exercises may increase efficacy of flu vaccine
2. Study reveals gaps in vaccine financing for underinsured children
3. Trials underway for essential new TB vaccine
4. Hib vaccine: A critical ally in Asias effort to reduce child deaths
5. Progress toward an antitumor vaccine
6. Chemotherapy may enhance the effectiveness of brain tumor vaccines
7. OHSU Cancer Institute shows findings of immunotherapy vaccine in prostate cancer patients
8. International studies show high efficacy for HPV vaccine
9. Vaxfectin-formulated measles DNA vaccine elicits long-term protection in nonhuman primates
10. Papillomavirus vaccine could substantially reduce cervical cancer incidence
11. Data on new vaccine for prostate cancer to be presented

Post Your Comments:
(Date:9/1/2015)... ... ... Agriculture innovation, urban farming, local food access, and sourcing from sustainable and ... 4th Annual Sustainable Agriculture Conference : “Innovation and the Rise of Local Food,” ... keynotes Pierre Sleiman, founder and CEO of Go Green Agriculture, and Daron “Farmer D” ...
(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... ... and Qualification of Laboratory Instruments in accordance with GMP requirements“ , featuring Ed ... on October 6th, 2015 at 11:00 EDT (15:00 GMT). , Calibration, qualification, ...
(Date:9/1/2015)... ... September 01, 2015 , ... Suzanne Bakken, PhD, ... at the Institute of Medicine (IOM) of the National Academies. , She is ... School of Nursing. A member of the Institute of Medicine since 2006, Bakken ...
(Date:9/1/2015)... ... September 01, 2015 , ... ... 1,500 investor-families have received permanent green cards (I-829 petition approval) from the USCIS ... petition is the final step of the EB-5 visa process for immigrant investors ...
(Date:9/1/2015)... MO (PRWEB) , ... September 01, 2015 , ... ... Wednesday, September 9, 2015 from 5:00 to 8:00 pm at the Marriott Indianapolis ... and groups with career opportunities will be attending from across the country. All ...
Breaking Medicine News(10 mins):Health News:Experts in Urban and Local Food Systems Development to Address Seedstock Sustainable Agriculture Conference Nov. 3-4 Discounted ticket sales end Sept. 4 2Health News:Experts in Urban and Local Food Systems Development to Address Seedstock Sustainable Agriculture Conference Nov. 3-4 Discounted ticket sales end Sept. 4 3Health News:Experts in Urban and Local Food Systems Development to Address Seedstock Sustainable Agriculture Conference Nov. 3-4 Discounted ticket sales end Sept. 4 4Health News:Experts in Urban and Local Food Systems Development to Address Seedstock Sustainable Agriculture Conference Nov. 3-4 Discounted ticket sales end Sept. 4 5Health News:Live Webinar from Pharmaceutical Technology and METTLER TOLEDO on Calibration and Qualification of Laboratory Instruments 2Health News:Columbia Nursing’s Suzanne Bakken Named Distinguished Institute of Medicine Nurse Scholar-in-Residence 2Health News:CanAm Enterprises Reaches Another Milestone with More Than 1,500 I-829 Petition Approvals 2Health News:PracticeMatch to Host Physician Career Fair at the Marriott Indianapolis Downtown on September 9, 2015 2Health News:PracticeMatch to Host Physician Career Fair at the Marriott Indianapolis Downtown on September 9, 2015 3Health News:PracticeMatch to Host Physician Career Fair at the Marriott Indianapolis Downtown on September 9, 2015 4
(Date:9/1/2015)... AMESBURY, Mass. , Sept. 1, 2015 /PRNewswire/ ... developing a next-generation infusion management system, closed on ... new investor WuXi Healthcare Ventures. Cardinal Partners, CICA, ... Partners also participated in the round. This financing ... $6B global infusion market. Leerink Partners LLC acted ...
(Date:9/1/2015)... 1. September 2015 In nur zwei ... Mitarbeitern hat die SHL Group schnell weltweit 3.000 ... rapides Wachstum auf dem Markt der ... und das Management von SHL wieder. ... ist weltweit führend in Design und Herstellung automatischer ...
(Date:9/1/2015)... , September 1, 2015 - ... GARFIELD-AF R egistry data presented at ... on the evolution of manag ... -   The first-ever two-year outcomes from ... ESC Congress 2015 expose that all-cause death was the most frequent major event ...
Breaking Medicine Technology:Ivenix Inc. Secures $42 Million in Funding 2Ivenix Inc. Secures $42 Million in Funding 3SHL Group erreicht wichtigen Markstein von 3.000 Mitarbeitern 2Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 2Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 3Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 4Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 5Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 6Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 7Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 8Global Atrial Fibrillation Registry Presents Two-Year Outcomes Data In More Than 17,000 Newly Diagnosed AF Patients 9
Cached News: