HOME >> MEDICINE >> NEWS
DNA vaccine against multiple sclerosis appears safe, potentially beneficial

A newly developed DNA vaccine appears safe and may produce beneficial changes in the brains and immune systems of individuals with multiple sclerosis, according to an article posted online today that will appear in the October 2007 print issue of Archives of Neurology, one of the JAMA/Archives journals.

In patients with multiple sclerosis (MS), the immune system attacks the myelin sheaths that protect nerve cells in the brain and spinal cord, according to background information in the article. The nerve cells axon, which transmits messages to other neurons, is eventually destroyed. The cause of MS is unknown, but evidence points to the involvement of immune cells and antibodies that recognize and attack specific substances in the myelin, such as myelin basic protein. Certain cytokines, small proteins produced by cells that trigger inflammation, also may play a role.

Amit Bar-Or, M.D., of the Montreal Neurological Institute and colleagues tested a DNA vaccine, BHT-3009, that encodes a full-length human myelin basic protein. Between 2004 and 2006, the researchers administered the vaccine to 30 patients with relapsing-remitting MS [characterized by symptomatic periods and periods of remission] or secondary progressive MS [when symptoms progressively worsen, but there still may be periods of remission]. After one, three, five and nine weeks, participants received intramuscular injections of placebo or BHT-3009 (in doses of .5 milligrams, 1.5 milligrams or 3 milligrams), with or without 80-milligram pills of atorvastatin calcium, a lipid-lowering drug previously shown to be effective in autoimmune conditions. After 13 weeks, participants who initially received placebo received four injections of BHT-3009.

Magnetic resonance imaging (MRI) and other safety evaluations were performed at the beginning of the study, and again after five, nine, 13, 26, 38 and 50 weeks. BHT-3009 was safe and well tolerated, provided favorable trends on brain MRI
'"/>

Contact: Susan Thomas
415-352-6262
JAMA and Archives Journals
13-Aug-2007


Page: 1 2

Related medicine news :

1. Traditional Chinese exercises may increase efficacy of flu vaccine
2. Study reveals gaps in vaccine financing for underinsured children
3. Trials underway for essential new TB vaccine
4. Hib vaccine: A critical ally in Asias effort to reduce child deaths
5. Progress toward an antitumor vaccine
6. Chemotherapy may enhance the effectiveness of brain tumor vaccines
7. OHSU Cancer Institute shows findings of immunotherapy vaccine in prostate cancer patients
8. International studies show high efficacy for HPV vaccine
9. Vaxfectin-formulated measles DNA vaccine elicits long-term protection in nonhuman primates
10. Papillomavirus vaccine could substantially reduce cervical cancer incidence
11. Data on new vaccine for prostate cancer to be presented

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/15/2018)... , ... November 15, 2018 , ... ... the American Academy of Facial Plastic and Reconstructive Surgery (AAFPRS) have elected Edward ... plastic surgeons in the specialty field of facial plastics and reconstruction, while AAFPRS ...
(Date:11/15/2018)... , ... November 15, 2018 , ... Over the last ... has raised more than $1.7 million for National Breast Cancer Foundation (NBCF) . ... to enjoy a safer lifestyle. The proceeds have helped launch the National Mammography ...
(Date:11/15/2018)... , ... November 15, 2018 , ... ... brands and products, now accepts Flexible Spending Account (FSA) and Health Savings Account ... to reduce the burden of healthcare spending for customers and improve the overall ...
(Date:11/15/2018)... (PRWEB) , ... November 15, 2018 , ... The National ... 2018. While advancing age is the primary risk factor for cancer and we typically ... people under the age of 45. And with aggressive treatment and advanced therapies, increasing ...
(Date:11/15/2018)... ... 15, 2018 , ... GoInvo, a digital health design consultancy ... Code”, ( https://www.goinvo.com/vision/loneliness-in-our-human-code/ ) the latest in a series of open source research ... social determinants of health, with a focus on loneliness, affect health over the ...
Breaking Medicine News(10 mins):
(Date:11/16/2018)... ... 2018 , ... Trident University International (Trident) has enhanced its ... desire to maintain a high level of academic standards and to best prepare ... returning students starting in the January 2019 Fastrac session. , This initiative ...
(Date:11/15/2018)... ... November 15, 2018 , ... All brokers in California ... ancillary benefits from the nation’s premier carriers. Previously, CoPower was sold exclusively through ... have access to top tier company benefits now that CoPower is no longer ...
(Date:11/15/2018)... ... November 15, 2018 , ... Ric Henry, President and Owner of Pendulum, ... or Consequences, New Mexico on Friday, November 2, 2018. Ric, who opened Sierra as ... of Directors. , Sierra Health Care Center has become known as one of ...
Breaking Medicine Technology:
Cached News: