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Data suggest bypass surgery free of long-term brain effects

that the population having the surgery is becoming older and sicker, with more hypertension, diabetes, previous strokes, and other disorders.

"In this paper, we reassessed what we think we know about cognitive decline attributable to the use of cardiopulmonary bypass versus cognitive decline due to pre-existing vascular disease of the brain," said Selnes. "Just about everyone agrees that some patients do suffer cognitive decline after CABG, but almost nobody agrees on how serious this decline is, and how long it lasts."

The authors find that the existing literature confirms the existence of mild deficits in the period up to three months after surgery, possibly due to minor disruption in blood flow that can be result from any major surgery, or other factors associated with surgery such as inflammation or complications of anesthesia.

But when they looked closely at the most authoritative studies -- those with appropriate control groups -- the authors failed to find strong evidence that cognitive deficits persist after three months in most patients.

"We believe that patients should not be discouraged from having CABG because of the risk of late cognitive decline," said Selnes.

He adds that their review emphasizes the need to have an appropriate control group when looking at cognitive outcomes after a surgical procedure.


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Contact: David Greenberg
dgreenbe@wiley.com
201-748-6484
John Wiley & Sons, Inc.
25-Apr-2005


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