HOME >> MEDICINE >> NEWS
Derivatives of cannabis for anti-cancer treatment win Kaye Award for Hebrew University student

Derivatives of the cannabis plant (hashish) have been shown by a Hebrew University of Jerusalem Ph.D. student to be effective in arresting cancerous growths in laboratory and animal tests.

For her work, Natalya Kogan was one of the winners of a Kaye Innovation Award, presented today during the 68th meeting of the Hebrew University Board of governors.

Working under the supervision of Prof. Raphael Mechoulam at the Hebrew University School of Pharmacy (in collaboration with Prof. Michael Schlesinger at the Hebrew University-Hadassah Medical School and Prof. Ester Priel at Ben-Gurion University of the Negev), Kogan has developed new compounds known as quinonoid cannabinoids that parallel in their activity a group of anti-cancer drugs, the best known of which is daunomycin.

However, while daunomycin is toxic to the heart, Kogan, with Dr. Ronen Beeri and Dr. Gergana Marincheva of Hadassah University Hospital, Ein Kerem, found that the quinonoid cannabinoids are much less cardiotoxic. The development of quinonoid compounds that display anticancer activity, but are less toxic, is a major therapeutic goal. At present, Kogan is continuing to investigate the mechanism of action of these promising compounds.

All of the compounds synthesized by Kogan inhibited cancer cell growth in cell culture, and one of them was found to markedly reduce the volume of tumors in animal studies The cannabinoid quinones were found to act through a rather unique pathway of cancer cell destruction -- by specific inhibition of topoisomerase II, an enzyme that participates in cell replication. Most of the known anti-cancer drugs are less selective, acting by numerous mechanisms.

Additionally, the most active compound in the series developed by Kogan, as well as some other cannabinoids, were found by Kogan and Prof. Ruth Galilli of the Hebrew University to have anti-angiogenic properties. Angiogenesis, the process of new blood vessel formation, is cr
'"/>

Contact: Jerry Barach
972-2-588-2904
The Hebrew University of Jerusalem
6-Jun-2005


Page: 1 2

Related medicine news :

1. Smokeless cannabis delivery device efficient and less toxic
2. Imaging technique sheds new light on the composition of the brain of moderate cannabis users
3. New antidepressant drug increases brains own cannabis
4. New algorithm matches any tumor cells to best possible anti-cancer treatments
5. UCLA researchers develop new nanomaterials to deliver anti-cancer drugs to cells
6. Vorinostat shows anti-cancer activity in recurrent gliomas
7. Research says boiling broccoli ruins its anti-cancer properties
8. Northwestern chemists develop new method for synthesizing anti-cancer flavonoids
9. Mistletoe is not an anti-cancer drug, say doctors
10. Erectile dysfunction drugs heighten natural anti-cancer activity
11. New litmus test could aid discovery of anti-cancer drugs

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... , ... October 13, 2017 , ... Ellevate Network, the ... business to advocate for action towards gender equality at their inaugural Summit in New ... the globe, and reached a social audience of over 3 million. To watch the ...
(Date:10/13/2017)... ... 13, 2017 , ... Coveros, a leader in agile coaching ... contract by the Center for Medicare and Medicaid Services (CMS). The Enterprise Agile ... of Agile methodologies in a consistent and high value manner across CMS programs. ...
(Date:10/12/2017)... ... October 12, 2017 , ... CitiDent ... sleep apnea using cutting-edge Oventus O2Vent technology. As many as 18 million ... by frequent cessation in breathing. Oral appliances can offer significant relief to about ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical ... Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. ... honor of Morris F. Collen, a pioneer in the field of medical informatics, this ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader in healthcare ... Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during ... , The annual award competition recognizes editorial and design excellence across a range of ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... South Korea , Oct. 4, 2017  South ... its next-generation CPR training aide "cprCUBE" on Kickstarter. The ... chest compression during cardiac arrests with better efficiency compared ... It also offers real-time feedback on efficacy of the ... The crowdfunding campaign has a goal to raise $5,000. ...
(Date:10/2/2017)... Oct. 2, 2017  Eli Lilly and Company (NYSE: ... for the third quarter of 2017 on Tuesday, October ... on that day with the investment community and media ... The conference call will begin at 9 a.m. Eastern ... a live webcast of the conference call through a ...
(Date:9/28/2017)... 2017 Hill-Rom Holdings, Inc. (NYSE: HRC), will ... and webcast on Friday, November 3, 2017, beginning at ... at approximately 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... financial performance and guidance for 2018, Hill-Rom executives will ... operational performance, and long-range financial outlook through 2020. ...
Breaking Medicine Technology:
Cached News: