HOME >> MEDICINE >> NEWS
Derivatives of cannabis for anti-cancer treatment win Kaye Award for Hebrew University student

Derivatives of the cannabis plant (hashish) have been shown by a Hebrew University of Jerusalem Ph.D. student to be effective in arresting cancerous growths in laboratory and animal tests.

For her work, Natalya Kogan was one of the winners of a Kaye Innovation Award, presented today during the 68th meeting of the Hebrew University Board of governors.

Working under the supervision of Prof. Raphael Mechoulam at the Hebrew University School of Pharmacy (in collaboration with Prof. Michael Schlesinger at the Hebrew University-Hadassah Medical School and Prof. Ester Priel at Ben-Gurion University of the Negev), Kogan has developed new compounds known as quinonoid cannabinoids that parallel in their activity a group of anti-cancer drugs, the best known of which is daunomycin.

However, while daunomycin is toxic to the heart, Kogan, with Dr. Ronen Beeri and Dr. Gergana Marincheva of Hadassah University Hospital, Ein Kerem, found that the quinonoid cannabinoids are much less cardiotoxic. The development of quinonoid compounds that display anticancer activity, but are less toxic, is a major therapeutic goal. At present, Kogan is continuing to investigate the mechanism of action of these promising compounds.

All of the compounds synthesized by Kogan inhibited cancer cell growth in cell culture, and one of them was found to markedly reduce the volume of tumors in animal studies The cannabinoid quinones were found to act through a rather unique pathway of cancer cell destruction -- by specific inhibition of topoisomerase II, an enzyme that participates in cell replication. Most of the known anti-cancer drugs are less selective, acting by numerous mechanisms.

Additionally, the most active compound in the series developed by Kogan, as well as some other cannabinoids, were found by Kogan and Prof. Ruth Galilli of the Hebrew University to have anti-angiogenic properties. Angiogenesis, the process of new blood vessel formation, is cr
'"/>

Contact: Jerry Barach
972-2-588-2904
The Hebrew University of Jerusalem
6-Jun-2005


Page: 1 2

Related medicine news :

1. Smokeless cannabis delivery device efficient and less toxic
2. Imaging technique sheds new light on the composition of the brain of moderate cannabis users
3. New antidepressant drug increases brains own cannabis
4. New algorithm matches any tumor cells to best possible anti-cancer treatments
5. UCLA researchers develop new nanomaterials to deliver anti-cancer drugs to cells
6. Vorinostat shows anti-cancer activity in recurrent gliomas
7. Research says boiling broccoli ruins its anti-cancer properties
8. Northwestern chemists develop new method for synthesizing anti-cancer flavonoids
9. Mistletoe is not an anti-cancer drug, say doctors
10. Erectile dysfunction drugs heighten natural anti-cancer activity
11. New litmus test could aid discovery of anti-cancer drugs

Post Your Comments:
(Date:7/24/2014)... Dr. Henry H. Ting, a nationally recognized ... appointed senior vice president and chief quality officer at ... role, he will oversee the hospital's clinical quality and ... quality initiatives and interprofessional teams at the local, regional ... Door-to-Balloon Alliance, a collaboration of more than 1,000 hospitals ...
(Date:7/24/2014)... breast tumors, exposure to dim light at night made ... according to data published in Cancer Research , ... The negative effects of dim light exposure on tamoxifen ... during the night. , "Resistance to tamoxifen is a ... said Steven M. Hill, PhD, professor of structural and ...
(Date:7/24/2014)... 25, 2014 Voted one of the ... global clients, BellasDress focuses on providing its new and ... information. Recently, the company has announced its new collection ... new range is created according to the latest fashion ... up to 68% off. , As a matter of ...
(Date:7/24/2014)... The report, “Content Delivery Networks (CDN) Market”, defines ... with an in-depth analysis and forecasting of revenues. ... this market with insights on trends, opportunities, and ... 36 figures spread through 157 pages and in-depth ... http://www.marketsandmarkets.com/Market-Reports/content-delivery-networks-cdn-market-657.html . , Early buyers will ...
(Date:7/24/2014)... July 24, 2014 Just as fitness ... must consider their own financial and marketing strength to ... marketing campaigns to the next level by using the ... Center, IVR, Voice Broadcast, Call Tracking and SMS ... open rate, text messages are quickly become integral in ...
Breaking Medicine News(10 mins):Health News:NewYork-Presbyterian Hospital Names New Senior Vice President for Quality and Patient Safety 2Health News:NewYork-Presbyterian Hospital Names New Senior Vice President for Quality and Patient Safety 3Health News:Exposure to dim light at night may make breast cancers resistant to tamoxifen 2Health News:BellasDress Helps Brides Get High End Wedding Dresses for Their Romantic Weddings 2Health News:CDN Market by Delivery Technologies & Solutions Expected to Reach $12.16 Billion by 2019 - New Report by MarketsandMarkets 2Health News:CDN Market by Delivery Technologies & Solutions Expected to Reach $12.16 Billion by 2019 - New Report by MarketsandMarkets 3Health News:CDN Market by Delivery Technologies & Solutions Expected to Reach $12.16 Billion by 2019 - New Report by MarketsandMarkets 4Health News:Pump Up Your Gym’s Marketing Muscles with Mobile Marketing: CallFire's Health & Fitness Webinar Week – July 28th to August 1st 2Health News:Pump Up Your Gym’s Marketing Muscles with Mobile Marketing: CallFire's Health & Fitness Webinar Week – July 28th to August 1st 3
(Date:7/24/2014)... , July 24, 2014  In any given hospital ... 25 patients has at least one hospital-acquired infection, according ... more, many of these infections prove fatal. And as ... alarming number of patient deaths per year, infection control ... Consequently, a stronger emphasis is being ...
(Date:7/24/2014)... Boston Children,s Hospital,s Global Pediatric Summit + Awards, ... Tank" – a forum designed to give pediatric health ... product solution to a panel of acclaimed judges for ... the innovation and bring it to market. ... will be moderated by Daymond John of ...
(Date:7/24/2014)... -- Cancer patients in the west of Scotland ... to home when a new radiotherapy center opens near ... VAR ) has been selected to equip the ... four TrueBeam™ medical linear accelerators. Two of ... and radiosurgery treatments, will replace older treatment machines at the ...
Breaking Medicine Technology:Employees, Equipment and the Environment: Top Infection Prevention Focuses in Hospitals 2Employees, Equipment and the Environment: Top Infection Prevention Focuses in Hospitals 3Taking on Tomorrow to Feature "Innovation Tank" Pitch Opportunity for Aspiring Pediatric Health Care Entrepreneurs 2Taking on Tomorrow to Feature "Innovation Tank" Pitch Opportunity for Aspiring Pediatric Health Care Entrepreneurs 3Varian Medical Systems Selected to Equip First Satellite Radiotherapy Center in Scotland 2Varian Medical Systems Selected to Equip First Satellite Radiotherapy Center in Scotland 3
Cached News: