"These study results support the growing body of evidence that, beyond its effects on blood glucose, pioglitazone may keep blood vessels healthy and prevent hardening of the arteries," noted principal investigator Thomas Forst, Professor for Internal Medicine, Institute for Clinical Research and Development in Mainz, Germany. "We are encouraged by these results because the benefits seen with pioglitazone could, theoretically, lead to an overall reduction in the incidence of heart attack and stroke for people with type 2 diabetes."
Carotid intima-media thickness occurs in the inner lining of a person's neck arteries, and is a strong indicator for cardiovascular risk because that is where cholesterol rich atherosclerotic plaque accumulates. A thickened carotid intima-media layer correlates with not only with the presence of cardiovascular risk factors, but also with the risk of future cardiovascular events such as heart attack and stroke. While blood pressure has long been a known predictor of heart disease, recent findings have indicated that testing CRP levels in the blood may be a new way to further assess cardiovascular disease risk. For people with type 2 diabetes, the risk of cardiovascular disease is two to four times that of the general population, thus making this population a very high-risk group.
This randomized, controlled study was designed to examine the effects of oral therapy with either pioglitazone (45 mg/day) or the blood gl
Contact: Amy Losak