HOME >> MEDICINE >> NEWS
Diabetes research at UH 'crystalizes' with major finding

HOUSTON, May 8, 2006 A University of Houston professor and his student have made a major discovery in the field of diabetes research and diagnosis, finding a new mechanism for the formation of insulin crystals in the pancreas.

Peter Vekilov, associate professor of chemical engineering, and Dimitra Georgiou, a recent doctoral graduate in chemical engineering, both in UH's Cullen College of Engineering, are behind this breakthrough. Since insufficient insulin production in the pancreas is one of the manifestations of adult-onset diabetes, Vekilov and Georgiou are studying the process of how insulin is produced in the first place. Understanding how the body creates this hormone will make it easier for researchers to discover why some individuals do not produce enough insulin and thus develop diabetes, Vekilov said. Specifically, the two have focused on the creation of insulin crystals, the form in which insulin is stored in the pancreas before it is released in the bloodstream.

"It is possible that the insulin deficiency happens when the crystals don't form properly and then part of the insulin that is produced gets destroyed," Vekilov said. Proinsulin, a molecular precursor to insulin itself, is the reason for these crystals. After an insulin molecule is produced from proinsulin, it attaches to an insulin crystal only in special locations where other insulin molecules have formed right angles, called kinks. Using atomic-force microscopy, they discovered a new mechanism by which insulin molecules attach themselves to crystals to form these kinks. They found that groups of insulin blocks create large protrusions, dubbed "mounds" by Vekilov and Georgiou. The very nature of these mounds results in the creation of multiple kinks far more, in fact, than other methods of kink formation.

By providing so many spaces where insulin molecules can attach to an insulin crystal, these mounds allow for the rapid growth of that crystal
'"/>

Contact: Lisa Merkl
lkmerkl@uh.edu
713-743-8192
University of Houston
8-May-2006


Page: 1 2

Related medicine news :

1. Diabetes professionals join forces to identify gaps in diabetes care and better self care
2. Lithotripsy, Hypertension and Diabetes: Is there a link?
3. Diabetes will be a bigger burden than predicted
4. Diabetes risk factors develop earlier in women than men
5. Diabetes drug may reduce cardiovascular risks
6. Diabetes, not obesity, increases risk of developing critical illness and early death
7. Diabetes confers health risk equivalent to ageing 15 years
8. Diabetes program demonstrates comprehensive care approach to NYC participants
9. Diabetes, heart disease can herald early GI cancers
10. Researcher wins award from American Diabetes Association
11. Diabetes epidemic could erase reductions in deaths & hospitalizations due to heart disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... , ... October 13, 2017 , ... While it’s often ... a problem. Fortunately, an inventor from Austin, Texas, has identified a solution. , She ... in darkness or restricted lighting. As such, it eliminates the need to turn on ...
(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a leading Health ... technology. Applying the Purzorb™process to full spectrum CBD oil will revolutionize the rapidly growing ... form that can be easily incorporated into liquid products, while reducing costs to end ...
(Date:10/13/2017)... ... 13, 2017 , ... Apple Rehab Shelton Lakes , which specializes in ... the facility as part of a disaster drill on October 3rd. , Apple Rehab ... City Emergency Manager, as well as the Connecticut Long Term Care Mutual Aid ...
(Date:10/13/2017)... ... , ... Ellevate Network, the leading network for professional women, brought together some ... at their inaugural Summit in New York City in June. The event was livestreamed ... over 3 million. To watch the Mobilize Women video, click here . ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... viewers the lowdown on sciatica in a new episode of "Success Files," which ... current events and innovation and investigates each subject in-depth with passion and integrity. ...
Breaking Medicine News(10 mins):
(Date:7/22/2018)... , ... July 20, 2018 , ... ... and part of the Adecco Group, today announced Golisano Children’s Hospital of Southwest ... received more than 250,000 total votes across 68 finalists in 2018. ...
(Date:7/22/2018)... ... July 20, 2018 , ... Fellow Health Partners, Inc., a ... College™, a first in the growing $22 billion dollar business of medical billing. The ... teams are grown and maintained at the highest level. , “We really want to ...
(Date:10/12/2017)... -- West Pharmaceutical Services, Inc. (NYSE: WST), ... administration, today announced that it will release third-quarter 2017 ... 26, 2017, and will follow with a conference call ... a.m. Eastern Time. To participate on the call, please ... is 94093362. A ...
Breaking Medicine Technology:
Cached News: