HOME >> MEDICINE >> NEWS
Diabetes researchers pioneer islet cell xenotransplantation in primate studies

A team of researchers from the University of Alberta, the Yerkes National Primate Research Center of Emory University and the Emory Transplant Center has successfully transplanted insulin-producing neonatal porcine islet cells into monkeys, a procedure the researchers say represents a promising intermediate solution to the critical supply problem in clinical islet cell transplantation.

"Our work at the U of A and Emory, along with recent work at the University of Minnesota, is very exciting and shows that xenotransplantation in humans may soon be possible, thus solving the islet supply problem," says one of the study authors Ray Rajotte, a professor of Surgery at the University of Alberta.

The paper appeared in an advanced on-line publication of Nature Medicine, February 26, entitled "Long-term survival of neonatal porcine islets in non-human primates by targeting co-stimulation pathways." The work follows on the heels of similar work published last week by University of Minnesota researchers; those researchers used islets isolated from adult pig pancreases.

Neonatal islets were produced in Edmonton using a procedure Drs. Greg Korbutt and Rajotte developed in 1995. The pig islets were sent to the Yerkes Research Center for transplantation into diabetic rhesus macaques using an anti-rejection protocol developed by Drs. Christian Larsen and Kenneth Cardona of the Yerkes Research Center and the Emory Transplant Center. The isolation method developed by the U of A researchers is simple and reproducible with the neonatal pig islets having some growth potential post-transplant, considered a major advantage over adult pig islets.

The diabetic animals were treated with a CD28/CD154 co-stimulation blockade-based immunosuppressive regimen, and achieved sustained insulin independence (median survival >140 days with one animal now at 300 days) without evidence of porcine endogenous retrovirus (PERV) dissemination. "This represents a major step fo
'"/>

Contact: Michael Robb
michael.robb@ualberta.ca
780-492-0647
University of Alberta
26-Feb-2006


Page: 1 2

Related medicine news :

1. Diabetes professionals join forces to identify gaps in diabetes care and better self care
2. Lithotripsy, Hypertension and Diabetes: Is there a link?
3. Diabetes will be a bigger burden than predicted
4. Diabetes risk factors develop earlier in women than men
5. Diabetes drug may reduce cardiovascular risks
6. Diabetes, not obesity, increases risk of developing critical illness and early death
7. Diabetes confers health risk equivalent to ageing 15 years
8. Diabetes program demonstrates comprehensive care approach to NYC participants
9. Diabetes, heart disease can herald early GI cancers
10. Diabetes research at UH crystalizes with major finding
11. Researcher wins award from American Diabetes Association

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/1/2020)... (PRWEB) , ... July 01, 2020 , ... ... that Doug Salvador, MD, Associate Professor of Medicine at the University of Massachusetts ... and Safety Strategies, LLC have joined the SIDM Board of Directors. Dr. Salvador ...
(Date:6/28/2020)... ... June 26, 2020 , ... Medisend College of Biomedical Engineering ... and training that prepares graduates for professional careers as field service engineers and ... of Trustees. , Ms. Williams currently serves as Associate Vice Chancellor of Workforce ...
(Date:6/28/2020)... ... June 26, 2020 , ... The ... the general public. As a supplier of top-quality masks, sanitizers and thermometers, Trusted ... PPE equipment. President Priya Agarwal observed, “All of our masks are manufactured to ...
(Date:6/28/2020)... , ... June 28, 2020 , ... ... around the world, dedicates World Allergy Week, from June 28 to July 4, ... by SARS CoV-2. , COVID-19, short for “coronavirus disease 2019”, is a disease ...
(Date:6/24/2020)... ... ... Evolved Naturals, a new brand of CBD health and beauty products, announced ... launched website showcases a variety of health and beauty CBD products including ... skincare & topical products . , Doug Gee, the CEO of Evolved Naturals, ...
Breaking Medicine News(10 mins):
(Date:7/7/2020)... ... July 07, 2020 , ... To support those on the front-lines of ... will be providing meals to the employees of Southern Nevada Health District. WGC Las ... Vegas on Wednesday, July 8th. , When asked why the Women of Global Change ...
(Date:7/7/2020)... ... July 07, 2020 , ... Halifax-based startup, Cribcut, ... a hair service provider. Now called Bright, the company has launched a workplace ... includes beauty amenities as well as an array of well-being services that can ...
(Date:7/2/2020)... ... July 02, 2020 , ... AllenComm, the leader in transformative ... Omni Awards for visually compelling compliance training , onboarding , brand ... exceed client and industry expectations as a digital transformation partner for learning and development ...
Breaking Medicine Technology:
Cached News: