BUFFALO, N.Y. -- The diabetes clock may start ticking in women years in advance of a medical diagnosis of the disease, new research has shown.
Epidemiologists at the University at Buffalo have found that newly identified risk factors for diabetes found in the blood, such as markers of endothelial dysfunction, chronic sub-acute inflammation and blood clotting factors, are present early on in women who eventually progress from normal glucose status to the pre-diabetic condition.
Pre-diabetes is diagnosed when blood sugar levels are higher than normal (between 100-125 mg/deciliter of blood), but not high enough to indicate full-blown diabetes (over 125 mg/deciliter of blood). The markers werent associated with progression from normal to pre-diabetic status in men.
Results of the study appear in the February 2007 issue of Diabetes Care.
This is one of the first reports to show that otherwise healthy women are more likely than men to show elevated levels of endothelial factors and other markers of progression to pre-diabetes, said lead author Richard Donahue, Ph.D., professor of social and preventive medicine and associate dean for research in UBs School of Public Health and Health Professions.
Because these pre-diabetic markers are not routinely assessed, and because diabetes is strongly linked with coronary heart disease, the study may help explain why the decline in death rates for heart disease in diabetic women lags behind that of diabetic men, he said.
Previous research had shown that hypertension and cholesterol were elevated among women who later developed diabetes. However, current findings that these novel risk factors [markers of endothelial dysfunction, chronic sub-acute inflammation and blood clotting factors] are elevated among women even earlier than previously recognized does suggest that the diabetes clock starts ticking sooner for women than for men.
The study involved 1,455 healthy participants originally
Contact: Lois Baker
University at Buffalo