HOME >> MEDICINE >> NEWS
Dietary folate intake not associated with breast cancer risk

Low dietary intake of folate was not linked to breast cancer risk, according to a systematic review in the November 15 issue of the Journal of the National Cancer Institute.

Folate, a vitamin that is abundant in fruits and vegetables, helps maintain DNA integrity, and a lack of it has been associated with DNA strand breaks and disruptions in DNA repair. Previous studies have suggested that increased folate intake may be associated with a reduced risk of breast cancer, but this association was not replicated by large studies that followed study participants prospectively. In addition, a common genetic change in the gene encoding a key enzyme in folate metabolism, called MTHFR, can lead to low folate levels in the body and therefore could be associated with breast cancer risk.

Sarah J. Lewis, of the University of Bristol in the United Kingdom, and colleagues searched Medline and the ISI Web of Knowledge for studies on folate intake and breast cancer risk. They assessed the relationship between folate intake and disease occurrence, being careful to note observational bias or error. They also examined the link between the common MTHFR polymorphism and breast cancer risk.

The authors found that many of the studies were subject to publication bias, dietary assessment measurement errors, confounding by factors associated with dietary intake, or recall bias. They did not observe a link between the common MTHFR alterations and breast cancer risk.

"We have reviewed the evidence from epidemiologic and genetic studies and found no consistent or reliable evidence to support a role of dietary folate in breast cancer prevention," the authors write.

In an accompanying editorial, Han-Yao Huang, Ph.D., of the Johns Hopkins Bloomberg School of Public Health in Baltimore, Md., writes, "The strength of evidence on the association between folate intake and breast cancer risk is very low, suggesting that any estimate of effect
'"/>

Contact: Andrea Widener
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
14-Nov-2006


Page: 1 2

Related medicine news :

1. New summary of Dietary Reference Intakes
2. Dietary intake of antioxidants associated with reduced risk of age-related macular degeneration
3. Annual Bibliography of Significant Advances in Dietary Supplement Research 2004
4. Dietary vitamin E may lower risk of Parkinsons disease
5. Antifolate therapies found effective against certain type of malaria
6. Excess folate linked to increased birth of twins after in-vitro fertilisation
7. Low folate levels may cut bowel cancer risk
8. Grain fiber and magnesium intake associated with lower risk for diabetes
9. Higher intake of fish and vitamin D levels linked to lower risk of age-related macular disease
10. Higher calcium and vitamin D intakes positively associated with brain lesions in older men and women
11. Comparison of 4 diet plans shows better outcomes for diet with lowest carbohydrate intake

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... ... Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with clinical ... the primary prevention of cardiovascular diseases during the 15th Annual Women’s Health ...
(Date:10/13/2017)... ... 13, 2017 , ... Apple Rehab Shelton Lakes , which specializes in ... the facility as part of a disaster drill on October 3rd. , Apple Rehab ... City Emergency Manager, as well as the Connecticut Long Term Care Mutual Aid ...
(Date:10/13/2017)... BASKING RIDGE, N.J. (PRWEB) , ... October 13, 2017 , ... ... second annual Holly Day Market. Featuring a collection of specialty vendors and unique items ... myriad of personalized and quality-focused health and wellness services offered by the VNA. ...
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids this ... by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited about ... ages; it is a non-competitive, non-timed event, which is all about having fun and ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... be giving viewers the lowdown on sciatica in a new episode of "Success ... focuses on current events and innovation and investigates each subject in-depth with passion ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Diplomat Pharmacy, Inc. (NYSE: DPLO ... LLC , and named its founder as Diplomat,s chief ... Tennessee , will operate under Diplomat subsidiary ... offerings for health care partners to include IT outsourcing, ... "In an interoperable world, technology delivers comprehensive insight ...
(Date:10/2/2017)... announces the European launch of their new low volume, high throughput ... Cambridge, U.K on October 4th. The new ... unprecedented speed and sensitivity while using far less sample volume through ... ... ...
(Date:9/28/2017)... , Sept. 28, 2017 Cohen Veterans Bioscience ... the use of wearable and home sensors for real-time ... Early Signal Foundation, a nonprofit organization focused on disruptive ... provide an affordable analytical system to record and integrate ... ...
Breaking Medicine Technology:
Cached News: