HOME >> MEDICINE >> NEWS
Different gene-expression predictors of breast cancer agree, UNC study shows

h are more robust and helpful."

To compare the individual predictions made by these different genomic tests, Perou and his colleagues at UNC and at The Netherlands Cancer Institute in Amsterdam, The Netherlands, studied the concordance of five different predictors that were all applied to a single data set of 295 tumor samples for which patient survival data was available relapse-free survival and overall survival.

Writing in the Aug. 10 issue of the New England Journal of Medicine, the researchers note that four predictors showed "significant agreement" in their outcome predictions on individual breast cancer patients, despite having little gene overlap. Of the three predictors showing the greatest concordance, two were the main assays that are commercially available and being used to guide clinical trials.

"If one assay said this patient was going to do poorly, then so did the other two," Perou said, noting that although the two commercial assays overlapped each other only by one gene, they were in 80 percent agreement with each other.

"This is good news for breast cancer patients. It means that different groups have independently arrived at tests which agree with each other and that they all do add information not provided by existing clinical tests," Perou said.

For example, several of the predictors in this study appear to predict the likelihood of breast cancer recurrence in various populations of women with node-negative disease.

Such information would be useful for identifying women who are unlikely to experience recurrence and, thus, potentially unlikely to benefit from chemotherapy.

"We find our results encouraging and interpret them to mean that although different gene sets are being used, they are each tracking a common set of biological characteristics that are present across different breast cancers and are making similar outcome predictions," Perou said.


'"/>

Contact: L. H. Lang
llang@med.unc.edu
919-843-9687
University of North Carolina School of Medicine
9-Aug-2006


Page: 1 2

Related medicine news :

1. Different type of iron supplement is better at boosting iron levels
2. Different options produce similar results
3. Different forms of amyloid beta in Alzheimers disease harm neurons in different ways
4. Different consultants mean different lengths of stay in hospitals
5. Differential heart-attack risks among blacks, whites remain mystery
6. Different antipsychotic medications may have different effects on brain volume
7. Study looks for genetic predictors of hypertension
8. Study identifies predictors of bipolar disorder risk
9. Mayo Clinic Cancer Center finds better predictors for outcomes after radical prostatectomy
10. Possible predictors of relationship violence
11. Childhood predictors of smoking in adolescence

Post Your Comments:
(Date:7/31/2015)... New York, New York (PRWEB) , ... ... ... Nationally renowned trial attorney Jason T. Brown’s live lecture on pharmaceutical negligence ... from July 28th, 2015 was well received with a 94% approval rating ...
(Date:7/31/2015)... ... July 31, 2015 , ... As part of their company mission, ... support of animal welfare organizations is essential to the longevity of their business. ... the National Association of Professional Pet Sitters (NAPPS) annual Presents 4 Pets supply drive. ...
(Date:7/31/2015)... ... July 31, 2015 , ... Transfinder, a software company ... Total sales were up 16 percent year-over-year for the first six months ended June ... said he expected Transfinder to beat last year’s record-revenue mark of $10.4 million. , ...
(Date:7/31/2015)... , ... July 31, 2015 , ... ... “HARMONY 2015”, one of the industry’s premier thought leadership symposiums, hosted by ... and 6. The event attracts over 250 “C”-level executives, administrators, directors of ...
(Date:7/31/2015)... ... 2015 , ... Mullin/Ashley Associates , a Mid-Atlantic branding, ... Awards national competition for a marketing communications campaign created for Atlantic General ... Coastal Maryland and Southern Delaware. , A Bronze Award was won for the ...
Breaking Medicine News(10 mins):Health News:Re-Broadcast of Nationally Renowned Trial Attorney Jason T. Brown's Lecture on Pharmaceutical Negligence Now Available 2Health News:Dallas-based Park Cities Pet Sitter Selects Non-Profit Animal Welfare Organization “Angie’s Friends” as this Year’s Recipient of their Presents 4 Pets Supply Drive. 2Health News:Dallas-based Park Cities Pet Sitter Selects Non-Profit Animal Welfare Organization “Angie’s Friends” as this Year’s Recipient of their Presents 4 Pets Supply Drive. 3Health News:Dallas-based Park Cities Pet Sitter Selects Non-Profit Animal Welfare Organization “Angie’s Friends” as this Year’s Recipient of their Presents 4 Pets Supply Drive. 4Health News:Transfinder Closes First Half of 2015 with Record Revenue 2Health News:Harmony Healthcare International Announces Speaker Line-up for “HARMONY 2015” 2Health News:Harmony Healthcare International Announces Speaker Line-up for “HARMONY 2015” 3Health News:Mullin/Ashley Associates Wins in the 2015 Aster Awards National Competition for Excellence in Medical Marketing 2
(Date:7/30/2015)... , July 30, 2015  Tandem Diabetes Care®, ... company and manufacturer of the t:slim® and t:flex™ ... into non-exclusive Development Agreements with Dexcom, Inc. to ... pumps with the Dexcom G5 and G6 continuous ... next generation pump platform with Dexcom,s future CGM ...
(Date:7/30/2015)... special edition of #MedicareMonday on Medicare,s 50 th anniversary. As Medicare celebrates 50 ... highlighting the success of the prescription drug benefit, commonly referred to as Part D. ... and videos here: http://onphr.ma/1INp9qQ ... ... ...
(Date:7/30/2015)... and VANCOUVER , July ... ) announced today that it will report its second ... Company management will host a conference call and live ... overview of financial results, clinical development programs and a ... webcast, log on to the Investor Relations page of ...
Breaking Medicine Technology:Tandem Diabetes Care Announces Development Agreement with Dexcom for Integration of Future Generation CGM Systems 2Tandem Diabetes Care Announces Development Agreement with Dexcom for Integration of Future Generation CGM Systems 3Happy 50th Anniversary Medicare! 2Happy 50th Anniversary Medicare! 3
Cached News: