HOME >> MEDICINE >> NEWS
Different gene-expression predictors of breast cancer agree, UNC study shows

h are more robust and helpful."

To compare the individual predictions made by these different genomic tests, Perou and his colleagues at UNC and at The Netherlands Cancer Institute in Amsterdam, The Netherlands, studied the concordance of five different predictors that were all applied to a single data set of 295 tumor samples for which patient survival data was available relapse-free survival and overall survival.

Writing in the Aug. 10 issue of the New England Journal of Medicine, the researchers note that four predictors showed "significant agreement" in their outcome predictions on individual breast cancer patients, despite having little gene overlap. Of the three predictors showing the greatest concordance, two were the main assays that are commercially available and being used to guide clinical trials.

"If one assay said this patient was going to do poorly, then so did the other two," Perou said, noting that although the two commercial assays overlapped each other only by one gene, they were in 80 percent agreement with each other.

"This is good news for breast cancer patients. It means that different groups have independently arrived at tests which agree with each other and that they all do add information not provided by existing clinical tests," Perou said.

For example, several of the predictors in this study appear to predict the likelihood of breast cancer recurrence in various populations of women with node-negative disease.

Such information would be useful for identifying women who are unlikely to experience recurrence and, thus, potentially unlikely to benefit from chemotherapy.

"We find our results encouraging and interpret them to mean that although different gene sets are being used, they are each tracking a common set of biological characteristics that are present across different breast cancers and are making similar outcome predictions," Perou said.


'"/>

Contact: L. H. Lang
llang@med.unc.edu
919-843-9687
University of North Carolina School of Medicine
9-Aug-2006


Page: 1 2

Related medicine news :

1. Different type of iron supplement is better at boosting iron levels
2. Different options produce similar results
3. Different forms of amyloid beta in Alzheimers disease harm neurons in different ways
4. Different consultants mean different lengths of stay in hospitals
5. Differential heart-attack risks among blacks, whites remain mystery
6. Different antipsychotic medications may have different effects on brain volume
7. Study looks for genetic predictors of hypertension
8. Study identifies predictors of bipolar disorder risk
9. Mayo Clinic Cancer Center finds better predictors for outcomes after radical prostatectomy
10. Possible predictors of relationship violence
11. Childhood predictors of smoking in adolescence

Post Your Comments:
(Date:10/20/2014)... Succeed is proud to announce that they ranked ... the Every Body Walk! campaign by Kaiser Permanente. ... encourages workers to be more active outside of the workplace. ... at the end of September, was a friendly competition between ... Participating companies gave their staff pedometers and each day, ...
(Date:10/20/2014)... Ohio (PRWEB) October 20, 2014 Unveiled at ... new Strategic Direction Scorecard conservatively estimates member hospital ROI on ... spent on dues, The Center provides $12.50 in value to ... is (Member Value – Member Dues)/Member Dues. , “This ... at this number and we think the methodology is really ...
(Date:10/20/2014)... Silver Spring, Maryland, USA (PRWEB) October 20, 2014 ... readers or to track interventions? Here comes a wonderful ... leading mobile app development company helped its ... track Intervention more efficiently. The app is designed for ... iPad, and iPod touch. This app is optimized for ...
(Date:10/19/2014)... Dr. Babatunde Osotimehin, Executive Director of ... a ceasefire agreement that is expected to lead to ... were kidnapped from the north-eastern Nigerian town of Chibok—the ... enough, and it is high time they are returned ... , "We owe it to these girls to positively ...
(Date:10/19/2014)... 20, 2014 Recently, Fancyflyingfox.com, an innovative ... clothes, has announced its latest designs of 2014 ... the new elegant outfits are offered with big discounts, ... order before October 30 can enjoy this special offer. ... marketing strategies, it has become one of the leading ...
Breaking Medicine News(10 mins):Health News:Succeed Management Solutions, LLC Competes in Walking Challenge and Achieves 12th Place in Portland 2Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 2Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 3Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 4Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 2Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 3Health News:Fancyflyingfox.com Updates Its Website With New Mother Of The Bride Dresses For 2014 2
(Date:10/20/2014)... octubre de 2014  PneumRx, Inc. ( www.pneumrx.com ... pulmonología intervencional, anunció hoy la conclusión de la ... antes de lo programado. El Estudio Clínico RENEW es ... investigación (IDE) aprobada por la FDA (Administración de ... de reducción de volumen pulmonar PneumRx RePneu, un ...
(Date:10/20/2014)...   BioNano Genomics announced today achievement of a ... human data at 30X depth, sufficient for a genome map, ... was established and demonstrated for the IrysChip TM V2, ... and will be rolled out to BioNano,s collaborators and ... this advancement at the American Society for Human Genetics ...
(Date:10/20/2014)... , Oct. 20, 2014   Mary,s Medicinals ... for Caring, is a 4-Star Sponsor of Operation ... Veterans with unique products, programs and services to assist ... freedom. Key Facts: , An ... is a safe and effective treatment for pain, Post-traumatic ...
Breaking Medicine Technology:PneumRx concluye inscripción en prueba fundamental RENEW 2PneumRx concluye inscripción en prueba fundamental RENEW 3BioNano Genomics Announces One Human : One Chip : One Day 2BioNano Genomics Announces One Human : One Chip : One Day 3Mary's Medicinals Announces 4-Star Sponsorship of Operation Grow4Vets 2Mary's Medicinals Announces 4-Star Sponsorship of Operation Grow4Vets 3
Cached News: