HOME >> MEDICINE >> NEWS
Discovery of key inflammation mechanism in COPD could lead to new treatments

An international team of researchers has identified a mechanism which increases lung inflammation, making Chronic Obstructive Pulmonary Disorder (COPD) more severe, and potentially points towards new treatments.

Reporting today in the New England Journal of Medicine, the team from Imperial College London, Royal Brompton Hospital and the University of British Columbia, Canada found a correlation between the increase in inflammation in the lungs and a loss of activity in an enzyme responsible for switching off inflammatory genes and cells, called histone deacetylase (HDAC).

Professor Peter Barnes, from Imperial College London and the Royal Brompton Hospital, and senior author of the research, said: "COPD is the only common cause of death in the western world that is increasing, affecting almost a million patients in the UK, and four million in the USA, and the identification of this molecular mechanism could be of enormous importance in how we treat COPD in the future."

The team believe that the loss of HDAC activity may also explain why COPD is not responsive to steroids, as steroids require HDAC in order to switch off the inflammation.

Previous research by Professor Barnes has shown that low doses of theophylline, a substance occurring in tea leaves which helps relax the bronchial tubes, could help restore HDAC activity, and potentially reverse the resistance to steroids.

Professor Barnes adds: "Although this research is at a fundamental level, the discovery that COPD affects HDAC activity, which in turn can be affected by theophylline, could be the first step towards the development of an effective treatment."

The researchers looked at lung tissue samples from 40 patients with a range of different COPD stages.


'"/>

Contact: Tony Stephenson
at.stephenson@imperial.ac.uk
44-20-7594-6712
Imperial College London
11-May-2005


Page: 1

Related medicine news :

1. Discovery of cellular processes which regulate hearts energy supply
2. Discovery in Bubble Boy disease gene therapy
3. Discovery of T-cell traffic control boosts new drug promise
4. Mayo collaboration: Discovery blocks breast cancer growth, stimulates immunity
5. Discovery may prevent life-threatening wasting disease in patients with chronic kidney disease
6. Discovery of a drug anticipation brain signal
7. Discovery of a molecular switch could lead to new ways of treating infection, including MRSA
8. Pathway links inflammation, angiogenesis and breast cancer
9. Fat protein cuts blood vessel inflammation, may help heart, Jefferson scientists find
10. Brain inflammation may be friend, not foe, for Alzheimers patients
11. Blood inflammation plays role in Alzheimers disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for professional women, ... towards gender equality at their inaugural Summit in New York City in June. The ... social audience of over 3 million. To watch the Mobilize Women video, click ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to the ... save lost souls in the Philippines. “The Journey: From the Mountains to the Mission ... of the Bible. She has taught all ages and currently teaches a class of ...
(Date:10/12/2017)... ... October 12, 2017 , ... The ... demand of today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, ... to meet the highest standard. , These products are also: Gluten Free, ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... Mohebi Hair Restoration, has recently contributed a medical article to the newly revamped ... cosmetictown.com. Dr. Mohebi’s article spotlights the hair transplant procedure known as Follicular ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... the nation's first interactive health literacy software tool, and the Cancer Patient Education ... of cancer patient education, today announce a new strategic alliance. , As ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... SAN DIEGO , Oct. 12, 2017   Divoti ... Medical Alert Jewelry up to the standard of the latest FDA ... (Launched: June 2017). Anyone in need of Medical ID ... Divoti Medical Alert Jewelry are engraved in terms of the ... ...
(Date:10/11/2017)... Oct. 11, 2017  True Health, a leader ... its effort during National Breast Cancer Awareness month ... risks. Research ... calculated that more than 10 million American women ... in BRCA1 or BRCA2 and have not had testing. ...
(Date:10/7/2017)... 6, 2017   Provista, a proven leader ... billion in purchasing power, today announced a new resource ... The Newsroom is the online home for case ... expert bios, news releases, slideshows and events. ... wealth of resources at their fingertips, viewers can also ...
Breaking Medicine Technology:
Cached News: