Loss of ovarian and/or adrenal function can cause many women to experience hypopituitarism or under-active pituitary glands, and therefore low levels of testosterone, which is responsible for producing estrogen. This lack of testosterone can be blamed for loss of sex drive, loss of muscle tone and decrease of cognitive sharpness.

Researchers, led by Karen K. Miller, M.D., wanted to determine whether using physiological testosterone replacement in the form of dermal patches would improve (1) bone density, (2) body composition and (3) neuro-behavioral function in these women with low testosterone levels resulting from hypopituitarism.

Fifty-one women of reproductive age with low testosterone levels from hypopituitarism participated in this 12-month study by wearing a testosterone-administering patch that delivered 300 mcg daily or a placebo. Researchers analyzed bone density, fat-free mass and fat mass, as well as thigh muscle and abdominal area. Mood, sexual function, quality of life and cognitive function were assessed by questionnaire.

Results demonstrated an encouraging effect, with few side effects, and may prove to be useful in the clinical setting for women with low testosterone levels resulting from under-active pituitary glands.

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Contact: Tadu Yimam
tyimam@endo-society.org
301-941-0251
The Endocrine Society & The Hormone Foundation
9-May-2006