"Antibiotics appear to have no benefit in the treatment of acute upper respiratory tract infections," conclude Dr. Bruce Arroll and Dr. Timothy Kenealy of the University of Auckland, New Zealand. "The implications for practice are that prescription of antibiotics should not be given in the first instance as they will not improve the symptoms and adult patients will get adverse effects."

In addition to the side effects, mainly diarrhea, "overuse can increase levels of antibiotic resistance in the community," the review advises.

Colds are caused by viruses and not bacteria, upon which antibiotics act, yet, says Arroll, "There is evidence of high usage of antibiotics for the common cold in spite of doubts about the efficacy of such therapy." The review appears in the current issue of The Cochrane Library, a publication of The Cochrane Collaboration, an international organization that evaluates medical research. Systematic reviews draw evidence-based conclusions about medical practice after considering both the content and quality of existing medical trials on a topic. Arroll reviewed 12 trials that included more than 1,900 patients with symptoms lasting for seven days or less or with colds that included runny noses with colored discharge for 10 days or less. The patients had been given either antibiotics or placebo. "People receiving antibiotics did no better in terms of lack of cure or persistence of symptoms than those on placebo," Arroll says.

The goal of the study, according to the authors, was to determine if antibiotics reduce general cold symptoms such as sneezing, inflammation of the nose and throat; if antibiotics have any effect on pus-like nasal discharge; and if antibiotics have significant s
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Contact: Bruce Arroll
b.arroll@aukland.ac.nz
Center for the Advancement of Health
19-Jul-2005