Robert M Douglas of the Australian National University, Canberra, and Harri Hemil of the University of Helsinki, Finland, reviewed the best quality studies on vitamin C and the common cold done over the last 65 years. All of these studies compared a daily dose of 200mg of vitamin C or more against a dummy pill (placebo).

Did vitamin C given for prevention reduce the risk of picking up a cold? The authors looked at 23 studies done in the general population, using doses of up to 2g daily, and found that vitamin C did not reduce the risk. They conclude that "the lack of effect of prophylactic vitamin C supplementation on the incidence of common cold in normal populations throws doubt on the utility of this wide practice."

In these prevention studies, those people who were given vitamin C and then caught a cold experienced a small reduction in the duration of the cold compared with those taking a placebo. The authors say that the clinical significance of this minor reduction "is questionable, although the consistency of these findings points to a genuine biological effect."

But the authors did find evidence that the vitamin could help prevent colds in people exposed to extreme physical exertion or cold weather. They found six studies in which the vitamin or a placebo was given to marathon runners, skiers and soldiers exposed to significant cold and/or physical stress. Those taking the vitamin experienced, on average, a 50% reduction in common cold incidence. The authors urge "great caution", though, in making generalizations from this finding in 6 st
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Contact: Paul Ocampo
pocampo@plos.org
415-624-1224
Public Library of Science
27-Jun-2005